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16977
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Nisin Lantibiotic Mitigates Brain Microbiome Dysbiosis and Alzheimer’s Disease-Like Neuroinflammation (UCLA Case No. 2024-096)
Researchers led by
P
rofessor Yvonne Kapila in the UCLA School of Dentistry have developed a technology that harnesses nisin, a well-characterized probiotic lantibiotic bacteriocin, as a novel therapeutic to address brain microbiome dysbiosis and Alzheimer’s disease (AD)-like neuroinflammation driven by periodontal disease. By targeting the microbial...
Published: 9/13/2025
|
Inventor(s):
Yvonne Ka
p
ila
Keywords(s):
Category(s):
Thera
p
eutics > CNS and Neurology
P
OLQ as a Mediator of Radioresistance in Prostate Cancer (UCLA Case No. 2024-068)
P
lease contact UCLA Technology Development Group for more information. KEYWORDS: cancer biology, cancer therapy resistance, molecular oncology, drug discovery, radiosensitization, radioresistance mechanisms, predictive biomarkers, prostate cancer
Published: 9/13/2025
|
Inventor(s):
P
aul Boutros
Keywords(s):
Category(s):
Thera
p
eutics > Oncology
,
Diagnostic Markers
Cohesive CLEM, TEM, FEBSEM System for MicroED and Cryo-EM A
p
plications (Case No. 2025-010)
Summary UCLA researchers have develo
p
ed a cohesive electron microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...
Published: 9/12/2025
|
Inventor(s):
Tamir Gonen
,
Michael Martynowycz
Keywords(s):
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Microsco
p
y And Imaging
,
Life Science Research Tools > Research Methods
,
Medical Devices
,
Medical Devices > Medical Imaging
,
P
latforms
Discrete A
p
proximation of Permanent Magnet Arrays (Case No. 2025-203)
Summary UCLA researchers have develo
p
ed Discrete-MAG, a discrete magnetic actuation / magnetics platform that delivers precise, programmable magnetic field manipulation at small scales. The system aims to control magnetic particles or micro-devices discretely for applications in sensing, actuation, imaging, or biological interfacing. Background Magnetic...
Published: 9/12/2025
|
Inventor(s):
Tyler Clites
,
He Kai Lim
,
Will Flanagan
,
Cameron Taylor
Keywords(s):
Category(s):
Materials
,
Materials > Functional Materials
,
Medical Devices
,
Mechanical
,
Mechanical > Robotics
,
P
latforms
,
P
latforms > Drug Delivery
,
Medical Devices > Medical Imaging
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
Multimeter-Wave Acoustic Resonators (Case No. 2025-167)
Summary Researchers at the University of Texas System have develo
p
ed multimeter-wave acoustic resonators using thin-film piezoelectric materials such as lithium niobate / lithium tantalate or aluminum nitride / scandium aluminum nitride, in combination with intermediate buffer layers. These resonators support higher-order antisymmetric bulk acoustic...
Published: 9/12/2025
|
Inventor(s):
Mark Goorsky
,
Ruochen Lu
,
Jack Kramer
,
Sinwoo Cho
,
Omar Barrera
Keywords(s):
Category(s):
Electrical
,
Electrical > Electronics & Semiconductors
,
Electrical > Signal
P
rocessing
,
O
p
tics & Photonics
Methods of Dealkenylative Amination and Azidation (UCLA Case No. 2024-032)
UCLA researchers led by
P
rofessor Ohyun Kwon have developed a toolkit for organic synthesis, providing chemists with a robust, selective, and practical solution for the construction of amine and azide functionalities via innovative dealkenylative strategies, opening new avenues in drug discovery and complex molecule assembly. The dealkenylative amination...
Published: 9/12/2025
|
Inventor(s):
Ohyun Kwon
Keywords(s):
Category(s):
P
latforms
,
Life Science Research Tools
Structure-Based Design of Antisense Oligonucleotide Drugs (UCLA Case No. 2020-916)
UCLA researchers led by
P
rofessor Feng Guo have developed a next-generation platform for designing antisense oligonucleotide (ASO) therapeutics using RNA structure as a blueprint, achieving enhanced specificity, efficacy, and versatility for the treatment of a wide spectrum of genetic and infectious diseases. INNOVATION: UCLA researchers in the Department...
Published: 9/12/2025
|
Inventor(s):
Feng Guo
,
Vaithilingaraja Arumugaswami
Keywords(s):
Category(s):
P
latforms
,
Thera
p
eutics > Infectious Diseases
,
Thera
p
eutics > Genetic Diseases
Hess Screen Test Chart Digitalization Tool (Case No. 2024-164)
Summary UCLA researchers have develo
p
ed a software-based digitizer for Hess Screen Test (HST) charts that automates extraction of gaze misalignment measurements across the visual field, converting paper charts into precise numerical eye-angle data. The system is faster, more repeatable, and more scalable than manual annotation. IOVS Background The...
Published: 9/12/2025
|
Inventor(s):
Qi Wei
,
Andrew Ryan
,
Jose
p
h Demer
Keywords(s):
Category(s):
Software & Algorithms
,
Software & Algorithms > Digital Health
,
Software & Algorithms > Image
P
rocessing
,
Medical Devices
,
Medical Devices > Medical Imaging
,
Medical Devices > Monitoring And Recording Systems
Self-Assembling Tetrahedral
P
rotein Cages Based on Machine Learning Algorithms (UCLA Case No. 2023-300)
P
lease contact our office for more information regarding this innovation. See also Technology -2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule Related publications (by the inventors only): Gladkov N, Scott EA, Meador K, Lee EJ, Laganowsky AD, Yeates TO, Castells-Graells R. Design of a symmetry-broken...
Published: 9/12/2025
|
Inventor(s):
Todd Yeates
Keywords(s):
Category(s):
Medical Devices
,
P
latforms > Drug Delivery
Construction of Low-Rate LD
P
C Codes From Rate-½ CCSDS Standard LDPC Codes (Case No. 2025-243)
Reference: UCLA Case No. 2025-243.
P
lease reach out to our office for more information.
Published: 9/12/2025
|
Inventor(s):
Richard Wesel
,
Semira Galijasevic
,
Linfang Wang
,
Jon Hamkins
,
Dariush Divsalar
Keywords(s):
Category(s):
Software & Algorithms
,
Software & Algorithms > Communication & Networking
,
Software & Algorithms > Security &
P
rivacy
,
Electrical
,
Electrical > Signal
P
rocessing
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