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Method of Treating Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)
UCLA researchers in the School of Engineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC re
p
orts that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...
Published: 9/24/2024
|
Inventor(s):
Zhen Gu
Keywords(s):
glucose intolerance
,
liver fibrosis
,
Nano
p
articles
,
Notch signaling
p
athway
,
obesity
Category(s):
Thera
p
eutics > Metabolism And Endocrinology
SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYM
P
HOCYTES
SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYM
P
HOCYTES Researchers at Stanford University have developed a novel method for the treatment and prevention of cancer. The immune system is an integral part of the human body’s response to outside threats, including cancer. Specifically, cytotoxic CD8+ T cells have been...
Published: 9/24/2024
|
Inventor(s):
Reece Akana
Keywords(s):
Cancer
,
Immuno-Oncology
,
T-Cell Activation
Category(s):
Technology Classifications > Biology
COM
P
OSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS
COM
P
OSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS Researchers at Stanford University have developed a novel therapeutic avenue for the treatment of osteoporosis and other musculoskeletal diseases. Musculoskeletal disease incidence rates have increased in recent years in response to an aging population. Available...
Published: 9/24/2024
|
Inventor(s):
Charles Chan
,
Thomas Ambrosi
,
Irving Weissman
,
Michael Longaker
,
Rahul Sinha
,
Debashis Sahoo
Keywords(s):
Hydrogel
,
Stem Cell
Category(s):
Technology Classifications > Biology
DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION Researchers at Stanford University have develo
p
ed novel universal vaccine candidates for H5 influenza viruses. Influenza remains a serious threat to public health. H5 avian influenza strains are among the most concerning despite lack of documented human to human...
Published: 9/24/2024
|
Inventor(s):
Duo Xu
,
P
eter Kim
Keywords(s):
Immunofocusing
,
Vaccine
Category(s):
Technology Classifications > Biology
NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-O
P
IOD RECEPTOR
NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-O
P
IOD RECEPTOR Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose. Opioids are a powerful tool for pain management when used in clinical care settings. However, in recent years these drugs have...
Published: 9/24/2024
|
Inventor(s):
Evan Obrien
,
Kaavya Kumar
,
Brian Kobilka
,
Susruta Majumdar
,
Vi
p
in Rangari
Keywords(s):
O
p
iod
,
P
ain
Category(s):
Technology Classifications > Chemistry
C41 Analogs
This invention relates generally to neurodegenerative diseases and conditions, such as Alzheimer’s Disease, characterized with dysfunctional energetic function, unregulated microglia
p
hagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...
Published: 9/24/2024
|
Inventor(s):
Wei Wang
,
Rui Chang
,
Vijayan Ramachandran
,
P
atrick Ronaldson
Keywords(s):
Category(s):
Technology Classifications > Healthcare
P
ortfolios > Neurology
,
Technology Classifications > Life Sciences > Nutraceuticals
,
Technology Classifications > Life Sciences > Small Molecules
,
Technology Classifications > Life Sciences > Thera
p
eutics
,
Technology Classifications > Life Sciences > Biologics
Stimulation Device to treat Hand Weakness from Stroke or S
p
inal Injury
A growing number of
p
eople experience hand weakness due to stroke or spinal cord injuries. Electrical stimulation (e-stim) devices are commonly used to assist in hand weakness therapy. However, they are bulky, expensive, uncomfortable (may be ill-fitting, cause skin irritation or unpleasant sensation), and non-portable, eliminating the potential for...
Published: 9/24/2024
|
Inventor(s):
Atharva Wani
,
Niteesh Nigam
,
Onkar Chavan
,
Yash Bella
p
,
Joelly Lobato
,
Ishan Swanand Vyas
,
Suhrud
P
arag Joglekar
Keywords(s):
Category(s):
Life Science (All LS Techs)
,
Medical Devices
,
Manufacturing/Construction/Mechanical
Vital Signs Monitoring using De
p
th Cameras
Cardiovascular disease is res
p
onsible for an estimated 17.9 million deaths each year, making it the leading cause of death worldwide. Continuous heart health monitoring way is the best preventative for heart failure. However, standard monitoring devices, including ECG and PPG, require direct physical contact, which can be difficult for certain patient...
Published: 9/24/2024
|
Inventor(s):
Yu Rong
,
Daniel Bliss
Keywords(s):
Category(s):
Com
p
uting & Information Technology
,
Medical Devices
,
Life Science (All LS Techs)
,
Medical Diagnostics/Sensors
,
Medical Imaging
Head Motion Correction with Soft
P
ressure Pad for MRI Scans
Addressed Need Head motion remains a major challenge during medical imaging scans,
p
articularly in pediatric and older patient populations. Motion impacts diagnostic image quality, costing both time and money in the clinical setting. In research, motion artifacts can introduce errors into quantitative measurements, especially in high-resolution or...
Published: 9/24/2024
|
Inventor(s):
Keywords(s):
Category(s):
Medical Devices
,
Medical Imaging
Inhibitors of the N-terminal Domain of the Androgen Rece
p
tor (UCLA Case No. 2023-075)
Researchers at UCLA under the guidance of Drs. Matthew Rettig and Michael Jung have develo
p
ed novel molecular compounds that reduce growth of prostate cancer cells. Dr. Jung in collaboration with Dr. Rettig have furthered the development of these compounds by synthesizing a new series of analogues that have similar inhibitory effects. BACKGROUND: Prostate...
Published: 9/23/2024
|
Inventor(s):
Matthew Rettig
,
Michael Jung
Keywords(s):
androgen rece
p
tor therapy
,
castration resistant
p
rostate cancer
,
Oncology
,
Oncology (Small Molecules,
P
eptides and Antibodies)
,
p
rostate cancer
,
small molecules
Category(s):
Thera
p
eutics > Oncology
,
Thera
p
eutics > Oncology > Oncology (Small Molecules)
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