Search Results - purification

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Peptide ligands for affinity capture of mRNA and methods of discovery thereof
RPI ID: 2022-060-301 Innovation Summary: This technology describes peptide ligands engineered for the affinity capture of nucleic acids, including DNA and RNA, in solution. These ligands are designed to bind selectively to nucleic acid targets, enabling efficient isolation and purification. The method includes synthesis and screening of peptide sequences...
Published: 3/10/2026   |   Inventor(s): Pankaj Karande, Mengyang Hu, Georges Belfort
Keywords(s): mRNA, Peptides, Purification, Vaccine
Category(s): Biotechnology and the Life Sciences
Ligand design method for affinity capture of mRNA in solution and on a surface and ligands discovered thereof
RPI ID: 2022-061-601 Innovation Summary: This technology describes ligands and associated methods for affinity capture of mRNA molecules in solution. The ligands are designed to bind selectively to mRNA surfaces, enabling efficient isolation and purification. The system supports scalable mRNA processing for therapeutic and research applications. It...
Published: 3/10/2026   |   Inventor(s): Todd Przybycien, Mirco Sorci, Thomas Neuman, Riddhi Banik, Georges Belfort
Keywords(s): mRNA, Purification, Vaccine
Category(s): Biotechnology and the Life Sciences
Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants
Abstract: Extracellular Vesicles (EVs), including exosomes and microvesicles, are nanometer-sized membranous vesicles that can carry different types of cargos, such as proteins, nucleic acids and metabolites. EVs are produced and released by most cell types. They act as biological mediators for intercellular communication via delivery of their cargos....
Published: 4/22/2025   |   Inventor(s): Jennifer Jones, Jay Berzofsky, Joshua Welsh, Katherine McKinnon
Keywords(s): Affinity, Biomarkers, CHROMATOGRAPHIC, EVs, Exo-Clean, Exosomes, Extracellular Vesicles, High-throughput, Jones, Microvesicles, purification, Resin
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, TherapeuticArea > Immunology
Expression, Purification, and Validation of Anthrax Toxin Proteins
Expression, purification, and validation of anthrax toxin proteins.
Published: 10/28/2024   |   Inventor(s): Rasem Fattah, Stephen Leppla
Keywords(s): Anthrax, Expression, proteins, purification, RM, toxin, Validation, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Human DNA Polymerase Gamma for Testing the Effect of Drugs on Mitochondrial Function
One of the primary means for treating HIV infection is the use of antiviral nucleotide or nucleoside analogs. These analogs work by inhibiting the activity of reverse transcriptase, the enzyme responsible for preparing the HIV genome for integration into the DNA of the host cell. Although these analogs do not have an effect on the polymerases responsible...
Published: 10/28/2024   |   Inventor(s): Rajesh Kasiviswanathan, Susan Lim, William Copeland
Keywords(s): CLONE, DDXXXX, DEFICIENT, Directed, DNA, DXXXXX, Enzyme, EXONUCLEASE, Expression, Gamma, Human, Improved, Includes, Listed LPM Campbell as of 4/15/2015, Method, Modifications, polymerase, Polymerase., Post LPM Assignment Set 20150420, Pre LPM working set 20150418, purification, recombinant, RXXXXX, SITE, TYPE, VLXXXX, Which, Wild, WIXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics
Cell Based Immunotherapy
The invention hereby offered for licensing is in the field of Immunotherapy and more specifically in therapy of autoimmune diseases such as Type I diabetes, multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosis and immune mediated allergies such as asthma as well as in transplantation-related disorders, such as graft acceptance...
Published: 10/28/2024   |   Inventor(s): Ethan Shevach, Dat Tran
Keywords(s): 2, ACTIVATED, ALLOWS, Aplastic anemia, Aplastic anemia, idiopathic; Aplastic anemia, Associated, CD121b, CELL-BASED, Cells, CULTURES, EXPANSION, Expression, FOXP3+, Generate, Graft versus host disease, Human, IB3XXX, IBXXXX, Idiopathic thrombocytopenic purpura, IL-l, Immunotherapy, IXXXXX, LAP, Latency, NUMBERS, Patent Category - Biotechnology, Peptide, purification, RECEPTOR, Regulatory, SELECTIVE, Sufficient, Systemic lupus erythematosus, T, Their, Thrombocytopenic purpura, autoimmune, TYPE
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials
Scalable Purification of AAV2, AAV4 or AAV5 Using Ion-Exchange Chromatography
Adeno-associated viruses (AAVs) constitute, as a group, the vehicle of choice for gene therapy because of several attractive features. Among others, AAVs are less pathogenic than other viruses, and they can be used for the long-term expression of therapeutic genes. This invention describes a simple ion-exchange (HPLC) methodology to purify different...
Published: 1/9/2026   |   Inventor(s): John (Jay) Chiorini, Nikola Kaludov
Keywords(s): AAV2, AAV4, AAV5, CHROMATOGRAPHY., GB2DXX, GB2XXX, GBXXXX, GXXXXX, ION-EXCHANGE, purification, SCALABLE
Category(s): Application > Therapeutics
High Level Expression and Purification of Untagged and Histidine-tagged Human Immunodeficiency Virus Type-1 Reverse Transcriptase
Human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT) gene encodes 560 amino acids. In the virus, however, HIV-1 RT occurs as a dimer of two related polypeptides, p66 and p51 subunits at a molar ratio of 1:1. The p51 subunit is derived from a C-terminal proteolytic cleavage of the p66 subunit. This invention describes a simplified protocol...
Published: 10/28/2024   |   Inventor(s): Rajendra Prasad, Ester Hou, Samuel Wilson
Keywords(s): BBXXXX, DDXXXX, DEXXXX, DXXXXX, Expression, High, Histidine-tagged, Human, Hyper IgM syndrome, Immunodeficiency, Immunodeficiency 2, Immunodeficiency 4, Immunodeficiency-3, Level, purification, Reverse, Severe combined immunodeficiency, x-linked, TRANSCRIPTASE, TYPE-1, Untagged, virus, Wiskott Aldrich syndrome
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease
Removal and Recovery of Rare Earth Elements
Project ID: D2022-17 Rare earth elements (REEs) are critical inputs for advanced technologies including permanent magnets, electronics, clean energy systems, fiber optics, and defense applications. Elements such as neodymium, europium, dysprosium, terbium, and yttrium are particularly important due to their unique magnetic, optical, and catalytic...
Published: 2/12/2026   |   Inventor(s): Jon Kirchhoff, Sandhya Adhikari, Govind Sharma Shyam Sunder
Keywords(s): Chelator, Extraction, Purification, Rare Earth, Solid-phase extraction, Sorbent
Category(s): Materials, Manufacturing
Novel Class of Materials for Boron Extraction
Project ID: D2009-11 Background Solid Phase Microextraction (SPME) has gained widespread acceptance and use in laboratories due to the fact that it is a solvent-less extraction technique, its mode of operation is relatively simple, easy to automate, and sampling and sample preparation are combined into one step. Until now, methods that coat SPME...
Published: 5/9/2024   |   Inventor(s): Jared Anderson, Fei Zhao, Yunjing Meng
Keywords(s): Boron, Extraction, Ionic Liquids, Purification, Separation membranes
Category(s): Coatings, Polymers, Materials
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