Search Results - regulatory

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Development of Immune System Tolerance for the Treatment of Autoimmune Disease
The present invention provides a therapeutic method for the treatment of autoimmune or autoinflammatory diseases by first breaking down the dysregulated immune system and then reprogramming the immune system to restore tolerance to the patient's self-antigens by induction of antigen specific regulatory T cells. The inventors have shown that only with...
Published: 10/28/2024   |   Inventor(s): Wanjun Chen
Keywords(s): Alloantigen-specific, Apototic, CELL-MEDIATED, Cells, IB3XXX, IBXXXX, INDUCTION, IXXXXX, Patent Category - Biotechnology, Prevention, Regulatory, REJECTION, T, TRANSPLANT
Category(s): TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
A Method to Expand a Population of Regulatory T Cells Optimal for the Treatment of Autoimmune Diseases
The transfusion of regulatory T cells (Tregs) has been used in the clinic to successfully prevent graft vs. host disease and is currently being evaluated in the treatment of other autoimmune diseases, such as organ graft rejection, type 1 diabetes and multiple sclerosis. Prior to transfusion, adoptive regulatory T cell transfer requires the expansion...
Published: 10/28/2024   |   Inventor(s): Ethan Shevach, Yong Chan Kim
Keywords(s): Cells, FOXP3+, Helios-expressing, Human, IBXXXX, IDXXXX, IXXXXX, oligonucleotides, Random-sequenced, Regulatory, Stabilization, T, Usingrandom-sequenced
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
T-Cell-Specific Gfi-1 Knockout Mouse
This is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells....
Published: 10/28/2024   |   Inventor(s): William Paul (Estate Of), Jinfang (Jeff) Zhu
Keywords(s): BAXXXX, Cells, FUNCTION, Gfi-1, Gfi1[fl/fl]-CD4Cre, IMPORTANT, KO, Mouse, Regulatory, REVEALS, RXXXXX, Specific, Strain, T, T-cell
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, ResearchProducts > Animal Models
Cell Based Immunotherapy
The invention hereby offered for licensing is in the field of Immunotherapy and more specifically in therapy of autoimmune diseases such as Type I diabetes, multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosis and immune mediated allergies such as asthma as well as in transplantation-related disorders, such as graft acceptance...
Published: 10/28/2024   |   Inventor(s): Ethan Shevach, Dat Tran
Keywords(s): 2, ACTIVATED, ALLOWS, Aplastic anemia, Aplastic anemia, idiopathic; Aplastic anemia, Associated, CD121b, CELL-BASED, Cells, CULTURES, EXPANSION, Expression, FOXP3+, Generate, Graft versus host disease, Human, IB3XXX, IBXXXX, Idiopathic thrombocytopenic purpura, IL-l, Immunotherapy, IXXXXX, LAP, Latency, NUMBERS, Patent Category - Biotechnology, Peptide, purification, RECEPTOR, Regulatory, SELECTIVE, Sufficient, Systemic lupus erythematosus, T, Their, Thrombocytopenic purpura, autoimmune, TYPE
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials