Search Results - immunodeficiency

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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038) INVENTORS Richard Silverman Weinberg College of Arts and Sciences, Department of Chemistry SHORT DESCRIPTION Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 4/30/2026   |   Updated: 4/1/2026   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Gene Therapy for DOCK8 Deficiency (UCLA Case No. 2023-178)
UCLA researchers in the Department of Pediatrics Allergy and Immunology have developed a gene therapy method to express the full-length DOCK8 protein in cells, aimed at treating DOCK8 deficiency. These method allows for safe and effective DOCK8 expression in hematopoietic stem cells without the need for an HLA-matched donor, enabling patients to undergo...
Published: 7/17/2025   |   Updated: 2/18/2025   |   Inventor(s): Caroline Kuo
Keywords(s): bone marrow, bone marrow transplants, DOCK8, DOCK8 deficiency, Gene Editing Systems, Gene Therapy, hematopoietic stem cells, Immune System, immunodeficiency, Immunology, intein splicing
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Life Science Research Tools > Plasmids/Vectors
Clotrimazole as a treatment for immunodeficiency disorders
NU 2020-021 INVENTORS Hossein Ardehali* Adam De Jesus SHORT DESCRIPTION A drug that elicits inflammatory response as a therapeutic for immunodeficiency disorders ABSTRACT The primary hallmarks of Immunodeficiency disorders include suppression of the immune system and impaired response to infection, which can be fatal. There is currently a lack of...
Published: 3/31/2026   |   Updated: 4/26/2023   |   Inventor(s):  
Keywords(s): Immunodeficiency, Immunology, Therapeutics
Category(s): Life Sciences > Therapeutics
High Level Expression and Purification of Untagged and Histidine-tagged Human Immunodeficiency Virus Type-1 Reverse Transcriptase
Human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT) gene encodes 560 amino acids. In the virus, however, HIV-1 RT occurs as a dimer of two related polypeptides, p66 and p51 subunits at a molar ratio of 1:1. The p51 subunit is derived from a C-terminal proteolytic cleavage of the p66 subunit. This invention describes a simplified protocol...
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): Rajendra Prasad, Ester Hou, Samuel Wilson
Keywords(s): BBXXXX, DDXXXX, DEXXXX, DXXXXX, Expression, High, Histidine-tagged, Human, Hyper IgM syndrome, Immunodeficiency, Immunodeficiency 2, Immunodeficiency 4, Immunodeficiency-3, Level, purification, Reverse, Severe combined immunodeficiency, x-linked, TRANSCRIPTASE, TYPE-1, Untagged, virus, Wiskott Aldrich syndrome
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease