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Search Results - mrna
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Peptide ligands for affinity capture of
mRNA
and methods of discovery thereof
RPI ID: 2022-060-301 Innovation Summary: This technology describes peptide ligands engineered for the affinity capture of nucleic acids, including DNA and RNA, in solution. These ligands are designed to bind selectively to nucleic acid targets, enabling efficient isolation and purification. The method includes synthesis and screening of peptide sequences...
Published: 3/10/2026
|
Inventor(s):
Pankaj Karande
,
Mengyang Hu
,
Georges Belfort
Keywords(s):
mRNA
,
Peptides
,
Purification
,
Vaccine
Category(s):
Biotechnology and the Life Sciences
Ligand design method for affinity capture of
mRNA
in solution and on a surface and ligands discovered thereof
RPI ID: 2022-061-601 Innovation Summary: This technology describes ligands and associated methods for affinity capture of
mRNA
molecules in solution. The ligands are designed to bind selectively to mRNA surfaces, enabling efficient isolation and purification. The system supports scalable mRNA processing for therapeutic and research applications. It...
Published: 3/10/2026
|
Inventor(s):
Todd Przybycien
,
Mirco Sorci
,
Thomas Neuman
,
Riddhi Banik
,
Georges Belfort
Keywords(s):
mRNA
,
Purification
,
Vaccine
Category(s):
Biotechnology and the Life Sciences
Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs
A fast, less expensive, and more reliable method for assessing
mRNA
degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics. Background: The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...
Published: 1/29/2026
|
Inventor(s):
Igor Lednev
,
Alexander Shekhtman
,
Lamyaa Almehmadi
,
Sergei Reverdatto
Keywords(s):
drug stability
,
mRNA
,
mRNA
stability
,
Raman spectroscopy
,
RNA
,
Technologies
,
vaccine stability
,
vaccines
Category(s):
Campus > University at Albany
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Therapeutics and Vaccines
MANIPULATING SPATIAL RNA LOCALIZATION
MANIPULATING SPATIAL RNA LOCALIZATION Researchers at Stanford have developed an inducible and programmable CRISPR-mediated transcript organization (CRISPR-TO) method for repositioning RNAs to various desired subcellular compartments. Spatial RNA transcriptomics, including subcellular
mRNA
localization, is a core mechanism for spatiotemporal regulation...
Published: 2/14/2024
|
Inventor(s):
Lei Qi
,
Mengting Han
Keywords(s):
Localization
,
mRNA
,
Neuron
Category(s):
Technology Classifications > Biology
Chimeric Antigen Receptor (CAR) that Targets Chemokine Receptor CCR4 and its Use in Treating Cancer
Abstract: The chemokine receptor, CCR4 is a seven transmembrane G protein-coupled cell surface receptor molecule with selective expression on cells of the hematopoietic system. In adult T cell leukemia (ATL), the cell-surface expression of CCR4 on leukemic cells has been found to be nearly universal. Therefore, a CCR4-directed chimeric antigen receptor...
Published: 4/22/2025
|
Inventor(s):
Liyanage Perera
,
Thomas Waldmann
Keywords(s):
Adult T Cell Leukemia
,
ALLOGENIC
,
ATL
,
CCR4
,
CD3+
,
Chemokine Receptor 4
,
Immunotherapy
,
Lymphoid Malignancy
,
mRNA
,
natural killer cell
,
NK
,
Perera
,
solid tumor
,
T cell
Category(s):
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Therapeutics
mRNA
Therapeutic Against the SARS-CoV-2 Spike Protein
Background Vaccines have shown great efficacy against SARS-CoV-2, the pathogen of COVID-19; however, methods of treatment are required for patients suffering from COVID‑19. More than 15 million cases with over 600,000 deaths have resulted from the ongoing coronavirus disease 2019 (COVID-19). SARS-CoV-2, the pathogen of COVID-19, is a β-coronavirus...
Published: 8/4/2025
|
Inventor(s):
Gaurav Sahay
,
Anindit Mukherjee
,
Jeonghwan Kim
Keywords(s):
antiviral
,
Drug
,
Drug Delivery
,
mRNA
,
mRNA
carrier
,
mRNA
delivery
Category(s):
Therapeutics