Search Results - mrna

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Pancreas-specific mRNA delivery enabled by sulfonium lipid nanoparticles

This technology presents a novel class of lipid nanoparticles engineered for targeted delivery of mRNA specifically to the pancreas following systemic administration. Background: Effective delivery of RNA therapeutics to specific organs remains a significant challenge in biomedical research. The pancreas, in particular, has been a difficult target...

Published: 6/12/2026 | Updated: 6/11/2026 | Inventor(s): Yamin Li, Yuqin Men

Keywords(s): mRNA, nanoparticle-enhanced delivery, nanoparticles, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

Raman Spectroscopy for Probing Encapsulation of mRNA in Lipid Nanoparticles

This technology uses deep ultraviolet Raman spectroscopy and advanced data analysis to quickly and non-destructively measure how much mRNA is unencapsulated in lipid nanoparticles, improving quality control for mRNA vaccines and therapeutics without chemical labels. Background: Messenger RNA (mRNA) therapeutics, particularly those delivered via lipid...

Published: 6/12/2026 | Updated: 6/11/2026 | Inventor(s): Igor Lednev, Alexander Shekhtman, Sergei Reverdatto, Sila Jin, Young Mee Jung

Keywords(s): mRNA, Raman spectroscopy, spectroscopy, statistical analysis, Technologies, therapeutics, vaccines

Category(s): Campus > University at Albany, Technology Classifications > Gene Therapy

Lung-targeting mRNA-lipid nanoparticles for the treatment of acute lung injury

This technology uses lung-targeting lipid nanoparticles to deliver IL-10 mRNA directly to the lungs, reducing inflammation and injury in conditions like acute lung injury and ARDS, while minimizing side effects and improving treatment effectiveness. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe, life-threatening...

Published: 3/19/2026 | Updated: 3/19/2026 | Inventor(s): Yamin Li, Yuqin Men, Qinghe Meng, Robert Cooney

Keywords(s): anti-inflammatory therapeutic, drug delivery, lipids, mRNA, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare

Peptide ligands for affinity capture of mRNA and methods of discovery thereof

RPI ID: 2022-060-301 Innovation Summary: This technology describes peptide ligands engineered for the affinity capture of nucleic acids, including DNA and RNA, in solution. These ligands are designed to bind selectively to nucleic acid targets, enabling efficient isolation and purification. The method includes synthesis and screening of peptide sequences...

Published: 3/10/2026 | Updated: 3/10/2026 | Inventor(s): Pankaj Karande, Mengyang Hu, Georges Belfort

Keywords(s): mRNA, Peptides, Purification, Vaccine

Category(s): Biotechnology and the Life Sciences

Ligand design method for affinity capture of mRNA in solution and on a surface and ligands discovered thereof

RPI ID: 2022-061-601 Innovation Summary: This technology describes ligands and associated methods for affinity capture of mRNA molecules in solution. The ligands are designed to bind selectively to mRNA surfaces, enabling efficient isolation and purification. The system supports scalable mRNA processing for therapeutic and research applications. It...

Published: 3/10/2026 | Updated: 3/10/2026 | Inventor(s): Todd Przybycien, Mirco Sorci, Thomas Neuman, Riddhi Banik, Georges Belfort

Keywords(s): mRNA, Purification, Vaccine

Category(s): Biotechnology and the Life Sciences

Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs

A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics. Background: The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...

Published: 1/29/2026 | Updated: 10/24/2025 | Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto

Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines

Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines

MANIPULATING SPATIAL RNA LOCALIZATION

MANIPULATING SPATIAL RNA LOCALIZATION Researchers at Stanford have developed an inducible and programmable CRISPR-mediated transcript organization (CRISPR-TO) method for repositioning RNAs to various desired subcellular compartments. Spatial RNA transcriptomics, including subcellular mRNA localization, is a core mechanism for spatiotemporal regulation...

Published: 2/14/2024 | Updated: 2/14/2024 | Inventor(s): Lei Qi, Mengting Han

Keywords(s): Localization, mRNA, Neuron

Category(s): Technology Classifications > Biology

Chimeric Antigen Receptor (CAR) that Targets Chemokine Receptor CCR4 and its Use in Treating Cancer

Abstract: The chemokine receptor, CCR4 is a seven transmembrane G protein-coupled cell surface receptor molecule with selective expression on cells of the hematopoietic system. In adult T cell leukemia (ATL), the cell-surface expression of CCR4 on leukemic cells has been found to be nearly universal. Therefore, a CCR4-directed chimeric antigen receptor...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Liyanage Perera, Thomas Waldmann

Keywords(s): Adult T Cell Leukemia, ALLOGENIC, ATL, CCR4, CD3+, Chemokine Receptor 4, Immunotherapy, Lymphoid Malignancy, mRNA, natural killer cell, NK, Perera, solid tumor, T cell

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

mRNA Therapeutic Against the SARS-CoV-2 Spike Protein

Background Vaccines have shown great efficacy against SARS-CoV-2, the pathogen of COVID-19; however, methods of treatment are required for patients suffering from COVID‑19. More than 15 million cases with over 600,000 deaths have resulted from the ongoing coronavirus disease 2019 (COVID-19). SARS-CoV-2, the pathogen of COVID-19, is a β-coronavirus...

Published: 8/4/2025 | Updated: 12/16/2021 | Inventor(s): Gaurav Sahay, Anindit Mukherjee, Jeonghwan Kim

Keywords(s): antiviral, Drug, Drug Delivery, mRNA, mRNA carrier, mRNA delivery

Category(s): Therapeutics