Search Results - biotechnology+and+the+life+sciences

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3-D printed optics with internal structures
RPI ID: 2018-036-401 Innovation Summary: This invention introduces a three‑dimensional (3‑D) optical element that is manufactured using additive processes and contains internal or surface beam‑forming features. The optic accepts incident light on a first surface and emits a shaped beam from a second surface; the emitted distribution (wide, narrow,...
Published: 3/10/2026   |   Inventor(s): Nadarajah Narendran, Ukwatte Lokuliyanage Indi Perera
Keywords(s): 3D Printing, Additive Manufacturing, Lighting, Optics
Category(s): Biotechnology and the Life Sciences
Method for terahertz wave detection utilizing terahertz-enhanced acoustics
RPI ID: 2010-061-402 Innovation Summary: This invention enables true stand-off detection of terahertz (THz) radiation by converting THz–plasma interactions into detectable acoustic emissions. A femtosecond optical beam (single- or dual-color) is focused in air to create a laser-induced plasma that, under incident radiation (preferably THz, but...
Published: 3/10/2026   |   Inventor(s): Benjamin Clough, Jingle Liu, Xi-Cheng Zhang
Keywords(s):  
Category(s): Biotechnology and the Life Sciences
Organic phosphor functionalized inorganic nanoparticle/silicone nanocomposite
RPI ID: 2013-050-403 Innovation Summary: This invention introduces phosphor-functionalized nanoparticles consisting of an inorganic nanoparticle core with long- and short-chain surface polymers and organic phosphors. The controlled grafting densities of polymers enable uniform phosphor dispersion, improving optical transparency and efficiency. The...
Published: 3/10/2026   |   Inventor(s): Brian Benicewicz, Robert, Jr. Karlicek, Ying Li, Linda Schadler Feist, Richard Siegel, Peng Tao, Lei Wang
Keywords(s):  
Category(s): Biotechnology and the Life Sciences
Nanoparticle-enabled X-ray Magnetic Resonance Imaging (NXMR)
RPI ID: 2014-052-401 Innovation Summary: NXMRI combines X‑ray excitation of nanoparticles with MRI readout to localize contrast agents by monitoring changes in resonance parameters (T1/T2/T2*) induced by excitation. Nanoparticles (e.g., nanophosphors) embedded in tissue are energized by X‑rays or UV, altering their local magnetic environment. An MRI...
Published: 3/10/2026   |   Inventor(s): Wenxiang Cong, Matthew Getzin, Lars Gjesteby, Ge Wang
Keywords(s): Automated Shading, Blinds, Coatings\Adhesive Technology, Daylight Filter, Daylight Harvesting, Daylight Management, Electrical Engineering, Energy Management, Lighting & Illumination Technology, Louvers, Material Sciences\Engineering, Mechanical Shading, Optoelectronics Systems, Passive Filter, Photocromic, Shades
Category(s): Biotechnology and the Life Sciences
Cross-linkable matrix-free nanocomposites with tunable optoelectronic functionalities and the methods for their macro-, micro- or nano-structures construction
RPI ID: 2014-054-402 Innovation Summary: Introduces solid-state, matrix-free polymer nanocomposites built entirely from polymer-brush–grafted nanoparticles without a separate bulk polymer matrix. A multimodal (bi- or polydisperse) brush design places dense short chains near the nanoparticle surface for strong steric shielding while...
Published: 3/10/2026   |   Inventor(s): Charles Goodwin, Robert, Jr. Karlicek, Ying Li, Linda Schadler Feist, CHAITANYA ULLAL
Keywords(s): Amyloid Fibrils, Amyloidosis, Biomedical Engineering, Diagnostics, Measurement, Medical Device\Diagnostic Systems, Proteins, SEM1/SEM2, serum amyloid A, SEVI, Staining
Category(s): Biotechnology and the Life Sciences
In Vitro Culture Model of Anisotropic to Isotropic Transition
RPI ID: 2015-010-401 / 2015-010-601 Innovation Summary: A hybrid biomaterial platform integrates aligned electrospun fiber regions with adjacent isotropic film surfaces on a single culture substrate, creating a controlled anisotropic‑to‑isotropic boundary that models lesion‑edge transitions found in injured tissues such as spinal cord, tendon, and...
Published: 3/10/2026   |   Inventor(s): Gregory Desmond, Ryan Gilbert, Christopher Rivet, Jonathan Zuidema
Keywords(s): Architecture, Binaural Sound Localization, Biomedical Engineering, Echo Cancellation, Echo suppression, Electrical Engineering, Instrumentation, IT Hardware, Precedence Effect Model, Robotics, Sensors, Simulation and Modeling, Software
Category(s): Biotechnology and the Life Sciences
Method and Apparatus for enhancing sensitivity and resolution in a grating interferometer by machine learning
RPI ID: 2019-001-401 / 2019-001-601 Innovation Summary: A machine‑learning‑enhanced reconstruction pipeline improves both contrast sensitivity and spatial resolution in grating‑based X‑ray and neutron interferometry by fusing complementary image channels through a trained convolutional neural network (CNN). Paired interferometer images—capturing...
Published: 3/10/2026   |   Inventor(s): Ge Wang, Lee Seung Wook, Seho Lee
Keywords(s): convolutional neural network, Grating interferometer, High-sensitive phase contrast image, Image processing, machine-learning
Category(s): Biotechnology and the Life Sciences
Synthesis and Processing of Poly(pro-drug) Materials for Extended Drug Release and Uses Thereof
RPI ID: 2019-013-401 / 2019-013-601 Innovation Summary: A poly(pro‑drug) platform constructs biodegradable polymers in which the therapeutic molecule itself—such as estradiol, curcumin, or fingolimod—forms the repeating backbone, linked by cleavable ester, carbonate, or urethane groups and separated by hydrocarbyl or PEG‑based spacers....
Published: 3/10/2026   |   Inventor(s): Edmund Palermo, Anthony D'Amato, Ryan Gilbert, Samuel Ellman
Keywords(s): Biomaterial, Drug Delivery, hormone, pro-drug
Category(s): Biotechnology and the Life Sciences
Compounds and methods to target transmembrane domain of membrane proteins (e.g., APPTM) to inhibit intramembrane proteolysis
RPI ID: 2019-075-401, 2019-076-601 Innovation Summary: A substrate-specific inhibitor is proposed to block γ-secretase cleavage of amyloid precursor protein (APP), aiming to reduce amyloid-β (Aβ) production without affecting other physiological substrates. Unlike broad-spectrum γ-secretase inhibitors that target presenilin directly,...
Published: 3/10/2026   |   Inventor(s): Chunyu Wang
Keywords(s): Alzheimer's disease, amyloid, amyloid precursor protein, anti-Abeta, C99, gamma-secretase, intramembrane proteolysis, Notch, transmembrane domain of APP
Category(s): Biotechnology and the Life Sciences
A Method for Generating Functional Surface Coatings and Modifications via Self-Assembly of Silk Fibroin and Silk Fibroin-Like Macromolecules
RPI ID: 2019-087-401 Innovation Summary: A non-covalent, bottom-up coating method enables the formation of silk fibroin-based layers on chemically inert and geometrically complex surfaces. The process uses kosmotropic agents to facilitate smooth, homogeneous coatings that are tunable in thickness and free of inhomogeneities. These coatings can incorporate...
Published: 3/10/2026   |   Inventor(s): Runye Zha, Tanner Fink
Keywords(s): antifouling coatings, bioinert, Biomaterial, biomedical coatings, Implant, implant surface, protein structure, Self Assembly, silk, spidroin, Surface modification, surface treatment, thin film coatings, universal coating
Category(s): Biotechnology and the Life Sciences
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