Search Results - screening+assays

12 Results

Sort By:

Application A tool that measures cellular mechanical forces using flow cytometry. Key Benefits A fluorescently labeled approach based on the magnitude of molecular forces transmitted through cell adhesion receptors for evaluating mechanical forces in cells. A prototype has been developed showing proof -of-concept via the ability to determine mechanical...

Published: 2/28/2025 | Inventor(s): Rong Ma, Khalid Salaita

Keywords(s): Screening Assays

Category(s): TechPub Algolia > Research Tools

Assays for Labeling and Evaluating Lysine Methylation

Application A life science tool for evaluating protein lysine methylation for drug discovery and disease research. Key Benefits Highly specific labeling method for post-translational methylated lysine. Potential to improve the understanding of protein lysine methylation and help develop new drugs to block its interactions across several disease...

Published: 3/6/2025 | Inventor(s): Monika Raj, Ogonna Nwajiobi

Keywords(s): Biomarkers, Screening Assays

Category(s): TechPub Algolia > Diagnostics

Using Hetero-multivalent DNA-functionalized Materials to Detect Genetic Mutations

Application Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations. Key Benefits Tunable oligos increase specificity and cooperative binding to the disease target of interest. Distinguishes between cis- and trans mutations. Identifies different strains of...

Published: 2/13/2025 | Inventor(s): Brendan Deal, Khalid Salaita, Rong Ma, James Kindt

Keywords(s): COVID19, Screening Assays

Category(s): TechPub Algolia > Micro and Nanotechnology, TechPub Algolia > Diagnostics

Drug Screening System for Cardioprotection

Application A high throughput screening assay for developing therapies to protect from drug and alcohol-induced cardiotoxicity. Key Benefits A cardiovascular stem-cell-based screening assay that can identify drugs that protect the heart from toxic medications and alcohol. Preliminary data in the laboratory show the system is clinically relevant...

Published: 2/13/2025 | Inventor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du

Keywords(s): Cardiology and Vascular Devices, Screening Assays, Small Molecule

Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery

Real-Time RT-PCR Assay for SARS-CoV-2

Application Triplex, internally-controlled real-time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Two viral targets to confirm detection in a single sample. Does not involve the performance of multiple reactions as are required for the majority of published assays. May be performed using several different...

Published: 2/13/2025 | Inventor(s): Jesse Waggoner

Keywords(s): COVID19, Screening Assays

Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Research Tools

Ebola Specific Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) Assay

ApplicationA cell based assay to quantify the titer of circulating Ebola glycoprotein (GP) antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC).Key BenefitsSpecific for detection of ADCC activity of Ebola virus antibodies or antisera.Applicable to all pathogenic strains of Ebola virus.Ebola GP-specific stable reporter cells eliminate...

Published: 2/13/2025 | Inventor(s): Paul Spearman, Karnail Singh, Xuemin Chen

Keywords(s): Screening Assays

Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Diagnostics

Assay to Measure Cell Traction Forces for High Throughput Drug Screening and Mechanical Phenotyping

Application Mechanically induced catalytic amplification reaction (MCR) as an assay for high throughput screening of drugs which target cellular mechanics and mechanical phenotyping of live cells. Key Benefits Adaptable for high throughput screening of drugs that impair cell mechanics. Enables characterization of different cells types based on...

Published: 2/13/2025 | Inventor(s): Pui Yan Ma, Khalid Salaita

Keywords(s): Screening Assays

Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Drug Discovery, TechPub Algolia > Research Tools

Tool for Measuring Cell Purity and Quality Control of Stem Cell-based Products

Application Cell-based assay for sensitive and specific detection of undifferentiated cells in stem cell-related research and development. Key Benefits Nanotechnology-based assay can detect residual undifferentiated cells and characterize cultures that may be tumorigenic. Technology is potentially more sensitive method compared to current methods. Market...

Published: 2/13/2025 | Inventor(s): Chunhui Xu, Shuming Nie, Ximei Qian, Jingjia Han

Keywords(s): Cell Therapy, Regenerative Medicine, Screening Assays

Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Research Tools

Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses

Application A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key Benefits Potent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves...

Published: 2/13/2025 | Inventor(s): Richard Plemper, James Snyder, Aiming Sun

Keywords(s): Microbiology and Infectious Disease Treatments, Rare and Orphan Disease Treatments, Screening Assays

Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Research Tools

Clinical Assay Predicts Outcomes Based on Enzyme Activity

Application Clinical assay to predict therapeutic outcomes based on kinase or phostphatase activity. Key Benefits Eliminates inconsistencies stemming from variable baseline activity. Selective measurement of specific enzymatic activity within a heterogeneous sample. Technical Summary Researchers at Emory University have developed assays to...

Published: 3/6/2025 | Inventor(s): Jennifer Gooch, Jan Pohl, Brian Roberts

Keywords(s): Immunology and Inflammation Treatments, Screening Assays

Category(s): TechPub Algolia > Diagnostics

1 2