Search Results - will+flanagan

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Discrete Approximation of Permanent Magnet Arrays (Case No. 2025-203)

Summary UCLA researchers have developed Discrete-MAG, a discrete magnetic actuation / magnetics platform that delivers precise, programmable magnetic field manipulation at small scales. The system aims to control magnetic particles or micro-devices discretely for applications in sensing, actuation, imaging, or biological interfacing. Background Magnetic...

Published: 9/12/2025 | Inventor(s): Tyler Clites, He Kai Lim, Will Flanagan, Cameron Taylor

Keywords(s):

Category(s): Materials, Materials > Functional Materials, Medical Devices, Mechanical, Mechanical > Robotics, Platforms, Platforms > Drug Delivery, Medical Devices > Medical Imaging, Life Science Research Tools, Life Science Research Tools > Research Methods

Ampule-Based Synthesis of Sulfur-Porous Carbon Composites for Lithium-Sulfur Batteries

Background Lithium/sulfur (Li/S) batteries are garnering significant attention as a promising solution for next-generation electrochemical energy storage. Their potential to revolutionize the battery industry stems from several key advantages that address the limitations of current lithium-ion (Li-ion) technology. These advantages include an exceptionally...

Published: 8/21/2025 | Inventor(s): Yoon Hwa, David Wright, Yuhui An

Keywords(s): Chemicals, Energy storage, Engineering, Materials, Nanomaterials, Synthesis

Category(s): Energy & Power, Physical Science, Advanced Materials/Nanotechnology, Semiconductors, Materials & Processes

Beam-controlled Spectral-selective Architecture for a Radiative Cooler

This invention enhances radiative cooling of buildings by manipulating the divergent angle of thermal emission. By adjusting the direction at which heat is diverted away from buildings by this beam controlled design, the dependence of radiative cooling performance on the presence of surrounding architecture and environment can be minimized. US12352...

Published: 9/12/2025 | Inventor(s): Qiaoqiang Gan, Lyu Zhou, Zongfu Yu, Haomin Song

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Category(s): Technology Classifications > Energy Conservation

High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases

Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...

Published: 5/27/2025 | Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An

Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment

Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use

Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from Houston Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...

Published: 5/9/2025 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Oncology, Therapeutics

LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Therapeutics

Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer

Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...

Published: 8/13/2025 | Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji

Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...

Published: 3/24/2025 | Inventor(s): Zhiqiang An, Ningyan Zhang, Kathryn O'Donnell

Keywords(s):

Category(s): Diagnostics, Oncology, Therapeutics, Biologics

A Potent Short Hairpin RNA (SHRNA734) to Positively Select and Eliminate Genetically Modified Cells (UCLA Case No. 2016-524)

BACKGROUND: Gene therapy strategies to modify human stem cells hold great promise for curing many human diseases. However, previous clinical studies have met with limited success, largely due to the low engraftment of gene modified stem cells. One strategy to overcome this challenge involves engineering stem cells in which HPRT expression is knocked...

Published: 7/17/2025 | Inventor(s): Dong Sung An, Saki Shimizu

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Infectious Diseases

Method for Dry Battery Electrode Manufacturing Via Direct Powder Bed Formation and Compression

Background Recent efforts to address climate change and develop a clean-energy economy in the United States have focused on the electrification of the transportation sector. Sustainable battery manufacturing has become a critical part of these efforts, and current manufacturing practices face challenges relating to environmental impact, advancing electrode...

Published: 2/13/2025 | Inventor(s): Yoon Hwa, Yuhui An

Keywords(s): Battery, Energy storage, Engineering, Manufacturing, Powder

Category(s): Physical Science, Energy & Power, Alternative Energy, Semiconductors, Materials & Processes

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