Search Results - platform

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Next Gen Immune-Optimized Gene Delivery
Application An advanced gene therapy approach that improves therapeutic efficiency by protecting transgene expressing cells from host immune responses, through modulation of a key immune checkpoint pathway. Key Benefits Enhanced efficiency across viral and non-viral gene delivery systems, including AAV, lentivirus, LNPs, and electroporation. Enables...
Published: 3/11/2026   |   Inventor(s): Matthew (Matt) Gardner, Michael Kuipa, Abubakarr Koroma, Isai Leguizamo
Keywords(s): Biologics, Cell Therapy, Gene Therapy and Editing, Immunology and Inflammation Treatments, Oncology Treatments, Platform, Regenerative Medicine
Category(s): TechPub Algolia > Therapeutics
Non-invasive Diagnostic for Meningiomas
Application A non-invasive molecular diagnostic tool that reliably predicts the tumor characteristics and risk of recurrence of meningiomas. Key Benefits Combines meningioma gene expression data, construction of a gene interaction network, and tumor histology data to diagnose and predict clinical outcomes. Complete analytical handling from specimen...
Published: 1/28/2026   |   Inventor(s): Ali Alawieh, Youssef Ismail, Tomas Garzon-Muvdi
Keywords(s): Algorithm, AI, and Machine Learning, Biomarkers, Oncology Treatments, Personalized Medicine, Platform, Screening Assays
Category(s): TechPub Algolia > Diagnostics
Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time. Key Benefits Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva. Requires few reagents and no expensive equipment. Limit of detection on par with PCR and rapid readout. Enables...
Published: 2/5/2026   |   Inventor(s): Selma Piranej, Khalid Salaita
Keywords(s): COVID19, Molecular Diagnostics, Platform
Category(s): TechPub Algolia > Diagnostics
Next Generation L-Asparaginase Cancer Therapeutics
Application A humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits Human‑aligned variants may reduce immunogenicity and systemic toxicity compared to current FDA‑approved asparaginase drugs. Opportunity to improve treatment outcomes by minimizing the severe hypersensitivity reactions...
Published: 3/10/2026   |   Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
Keywords(s): Oncology Treatments, Pediatrics, Platform
Category(s): TechPub Algolia > Drug Discovery
Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow. Key Benefits Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear. Data generated by a prototype shows the system is fast and demonstrates precision compared to manual...
Published: 1/20/2026   |   Inventor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan
Keywords(s): Algorithm, AI, and Machine Learning, Hematology and Blood Products, Musculoskeletal Treatments, Platform
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Software, TechPub Algolia > Diagnostics
Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application Novel reagents for manufacturing of CAR T cells with improved characteristics. Key Benefits A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy. Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 9/3/2025   |   Inventor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
Keywords(s): Cell Therapy, Oncology Treatments, Platform, Production Methods
Category(s): TechPub Algolia > Micro and Nanotechnology
Liquid-hydrogel Hybrid Microfluidic Device
Application Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment. Key Benefits Fast determination of drug sensitivity. Long-term continuous cell-fate tracking. Time-lapse analysis of cell proliferation. Cell community analysis: intra-species interactions, inter-species interactions. Market...
Published: 1/20/2026   |   Inventor(s): Kyle Allison, Xin Fang, Devina Puri
Keywords(s): Medical Imaging (MRI, CT, Radiology), Microfluidics, Platform
Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Research Tools, TechPub Algolia > Medical Device
Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeutics
Intranasal delivery is a simple, inexpensive and needle-free route for administration of vaccines and therapeutics. This intranasal delivery technology, developed with Creare LLC., includes low-cost, disposable drug cartridges (DDCs) that mate with a durable hand-held device. The rechargeable-battery-powered device transmits ultrasonic energy to the...
Published: 8/13/2025   |   Inventor(s): James Barry, Nabil Elkouh, Mark Bagley, Darin Knaus, Robert Trabka, Eric Friets, James Norris, Mark Papania
Keywords(s): AB1XXX, AB3FXX, AB3GXX, AB3XXX, AB4XXX, Able, ABXXXX, AC1XXX, ACXXXX, AEROSOL, AEROSOL-GENERATING, AEROSOLIZATION, Aerosolized, AEROSOLS, AXXXXX, BACTERIA, Bacterial, BACTERIAL VACCINES, CARTRIDGE, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, Chamber, COOLING, DB1XXX, DB2XXX, DB3XXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DC2XXX, DC3XXX, DC4XXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, Delivery, DEVICE, Devices, Disposable, DRUG, Drug Delivery, DXXXXX, FUNGAL, HAND, Having, INSERT, Intranasal, Methods, NASAL, NEBULIZER, NIOSH-PRL, OID-NCIRD-DVD, PLATFORM, Platforms, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, System, SYSTEMS, therapeutic, therapeutic delivery, Vaccine, VACCINE DELIVERY, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, viral, viral vaccine, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XDXXXX, YBXXXX, YCXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Medical Devices, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology
Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirus
This CDC invention relates to primers and probes that specifically hybridize with Heartland virus (HRTLDV), a unique member of the genus Phlebovirus. It further relates to polyclonal antibodies specific for HRTLDV proteins. Serological detection assays using HRTLDV nucleic acid molecules, proteins, probes, primers, and antibodies are provided. Importantly,...
Published: 4/24/2025   |   Inventor(s): Stuart Nichol, William Nicholson, Cynthia Goldsmith, Aubree Kelly, Laura McMullan
Keywords(s): AC4XXX, ACXXXX, ANTIBODY, ANTIGEN, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4BXX, DA4XXX, DAXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Delivery, delivery system, DEVELOPED, diagnostic, DXXXXX, GB2CXX, GB2XXX, GBXXXX, GCXXXX, GENE THERAPY, gene transfer, GXXXXX, heartland, heartland virus, Hospitalized, Identification, ISOLATES, Isolation, Methods, Missouri, Novel, PATHOGENIC, PHLEBOVIRUS, PLATFORM, Platforms, sequence, therapeutic, therapeutic candidates, THEREOF, TICK, TICK-BORNE, TICKS, TWO, Vaccine, VACCINE VECTORS, Vector, Vector-based, Vector-borne, Vector-borne diseases, VETERINARY, VETERINARY vaccine, viral, virus, VLXXXX, VOXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, XHXXXX, YAXXXX, YBXXXX, Zoo
Category(s): Collaboration Sought > Licensing, ResearchProducts > Antibodies, ResearchProducts > Research Equipment, Application > Research Materials, TherapeuticArea > Immunology, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Consumer Products
A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development
An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human pathogen. Associated with complications during perinatal development and Guillain-Barré syndrome in adults, ZIKV raises new challenges for understanding the molecular determinants of flavivirus pathogenesis. This underscores the necessity for the development of a reverse...
Published: 8/13/2025   |   Inventor(s): Konstantin Tsetsarkin, Alexander Pletnev
Keywords(s): 2015, Brazil, cDNA, CLONE, DAXXXX, DBXXXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DD1XXX, DDXXXX, Development, DXXXXX, Epidemic, FULL-LENGTH, Genetic, INFECTIOUS, INTERACTIONS, PLATFORM, STUDIES, Vaccine, virus, Virus-Host, Zika
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Research Materials, Application > Diagnostics
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