Search Results - harrison+brown

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MPL Protein Targeting for Cancer Therapy and Transplant Preparation
Application Non-genotoxic hematopoietic stem cell transplantation conditioning regimen. Key Benefits Selective depletion of hematopoietic stem cells creates adequate niche space to allow donor engraftment without significant off target effect. Non-genotoxic conditioning regimen. CAR-T cells can have an anti-MPL positive leukemia effect before...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s): Shanmuganathan (Shan) Chandrakasan, H. (Harold) Trent Spencer, Christopher Doering, Lauren Fleischer, Gianna Branella, Jaquelyn Zoine, Harrison Brown
Keywords(s): Antibodies, Cell Therapy, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
Next Generation L-Asparaginase Cancer Therapeutics
Application A humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits Human‑aligned variants may reduce immunogenicity and systemic toxicity compared to current FDA‑approved asparaginase drugs. Opportunity to improve treatment outcomes by minimizing the severe hypersensitivity reactions...
Published: 4/10/2026   |   Updated: 12/1/2023   |   Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
Keywords(s): Oncology Treatments, Pediatrics, Platform
Category(s): TechPub Algolia > Drug Discovery