Search Results - production+methods

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Optimizing the Engineering of CAR-T Cells
Application A method for selecting distinct T cell populations in order to generate more effective CAR-T cells. Key Benefits The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells. This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 2/13/2025   |   Inventor(s): Byron Au-Yeung
Keywords(s): Cell Therapy, Oncology Treatments, Production Methods
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Advancing Lymphatic Endothelial Cell Generation from iPSCs
Application The developed protocol offers a reproducible and scalable method for generating lymphatic endothelial cells (LECs) from induced pluripotent stem cells (iPSCs), addressing critical challenges in the field of lymphatic-related therapies. Key Benefits Reproducible and scalable protocol for generating LECs from iPSCs. Utilizes specific...
Published: 2/13/2025   |   Inventor(s): Katherine Hekman, Katherine Owsiany
Keywords(s): Cell Therapy, Production Methods
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
Cost-Effective Catalysts for Industrial Chemical Applications
Application A cost-effective catalyst for industrial chemical applications as an alternative to expensive rhodium-dependent dirhodium catalysts. Key Benefits Alternative catalysts to dirhodium using a straightforward synthesis process. Preliminary data show the ability to self-assemble in a similar manner to dirhodium compounds. Significantly...
Published: 2/13/2025   |   Inventor(s): Huw Davies, Joshua Sailer, Jack Sharland, Bo Wei
Keywords(s): Chemistry, Production Methods
Category(s): TechPub Algolia > Non-Therapeutics
Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application Novel reagents for manufacturing of CAR T cells with improved characteristics. Key Benefits A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy. Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 2/13/2025   |   Inventor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
Keywords(s): Cell Therapy, Oncology Treatments, Platform, Production Methods
Category(s): TechPub Algolia > Micro and Nanotechnology
High-Throughput Platform for Imaging and Maintaining Cells in Culture
Application This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures. Key Benefits Automation of cell culture maintenance Integration...
Published: 2/28/2025   |   Inventor(s): Vahid Serpooshan, Ayda Melika, Amir Pourmorteza
Keywords(s): Cell Therapy, Platform, Production Methods
Category(s): TechPub Algolia > Software, TechPub Algolia > Medical Device, TechPub Algolia > Research Tools
Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein). Key Benefits Prevents the use of antibiotics and markers that promote resistance. Facilitates the deployment of recombinant bacteria in uncontrolled environments. Stabilizes heterologous expression of...
Published: 2/13/2025   |   Inventor(s): Ichiro Matsumura
Keywords(s): Enzyme and Protein Research, Platform, Production Methods
Category(s): TechPub Algolia > Research Tools
Platform for Transducing Target Cells with a Viral Vector
Application System for quickly and efficiently obtaining therapeutic levels of transduction. Key Benefits Uses less viral vector to achieve high gene transfer. Shortens transduction time. Produces clinically relevant gene modified cell numbers. Market Summary Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 2/13/2025   |   Inventor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
Keywords(s): Cell Therapy, Platform, Production Methods
Category(s): TechPub Algolia > Micro and Nanotechnology, TechPub Algolia > Research Tools
Specialized Cell Culturing Media for Enhanced Antibody Secretion and Plasma Cell Survival
Application Cell culture media that promotes the survival of human plasma cells and enables immunoglobin (Ig) secretion from such plasma cells. Key Benefits Facilitates the isolation of antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness. Composed of...
Published: 2/13/2025   |   Inventor(s): Frances Eun-Hyung Lee, Ignacio (Inaki) Sanz, Doan Nguyen
Keywords(s): Antibodies, COVID19, Production Methods
Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Research Tools, TechPub Algolia > Non-Therapeutics
Novel Vaccine Antigen Presentation Platforms
Application Combined antigen-adjuvant virus-like particle (VLP) vaccine platform for enhanced immune response. Key Benefits Chimeric VLPs (cVLPs) contain both antigen and adjuvant, thereby enhancing both cellular and humoral responses. cVLPs are safer than live replicating vectored vaccines because of their lack of infectivity. The cVLP manufacturing...
Published: 2/13/2025   |   Inventor(s): Baozhong Wang, Fu Shi Quan, Martin Moore, Richard Compans, Alan Aderem, Ioanna Skountzou, Jadranka Bozja
Keywords(s): Immunology and Inflammation Treatments, Microbiology and Infectious Disease Treatments, Platform, Production Methods, Vaccine Adjuvants
Category(s): TechPub Algolia > Vaccines
Library of Lipase-Based Biocatalysts Derived from CALB
ApplicationA lipase-based platform technology that can be used in the production of fine chemicals, detergents, and pharmaceuticals.Key BenefitsEnhanced thermostability, activity, and enantioselectivity of enantiopure compounds including bulky substrates. Can be used at a concentration 100x less than that of other enzymes. Technical SummaryLipases are...
Published: 2/13/2025   |   Inventor(s): Stefan Lutz, Zhen Qian
Keywords(s): Chemistry, Enzyme and Protein Research, Production Methods
Category(s): TechPub Algolia > Non-Therapeutics