Search Results - oncology+treatments

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Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...
Published: 11/13/2025   |   Inventor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee
Keywords(s): Drug Target Identification, Immunotherapy, Oncology Treatments, Small Molecule, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
Gene Editing for Head and Neck Cancer Treatment
Application Method for delivering gene-editing therapeutic in head and neck cancers. Key Benefits CRISPR/CAS9-based gene editing mechanism targeting novel disease-modifying gene. Liquid nanoparticle encapsulation permitting in vivo delivery. Market Summary Head and neck cancers (HNC) are the 7th most common global cancer, accounting for 3%...
Published: 11/7/2025   |   Inventor(s): Yong Teng, Yamin Li
Keywords(s): Drug Discovery, Drug Target Identification, Gene Therapy and Editing, Nanoparticle Drug Delivery, Oncology Treatments, Reagents, Biomaterials, and Plasmids
Category(s): TechPub Algolia > Therapeutics
Anticancer Agent with N-Glycan Specificity
Application An engineered protein for targeting disease-associated N-glycans. Key Benefits High affinity, pH insensitive, no cofactors required. Applications in anticancer and antiviral therapeutics and research. Can aid in manufacturing monoclonal antibodies with desired N-glycosylation properties. Market Summary Glycosylation involves post-translation...
Published: 11/3/2025   |   Inventor(s): Eric J. Sundberg, Diego Sastre, Maros Huliciak
Keywords(s): Antibodies, Biologics, Biomarkers, Drug Discovery, Drug Target Identification, Enzyme and Protein Research, Microbiology and Infectious Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
Molecules Targeting Inflammatory Signaling
Application A group of small molecules for treating central and peripheral diseases associated with inflammation. Key Benefits Applicable to a wide variety of central nervous system and peripheral diseases. Can bypass side effects of existing therapeutics targeting similar inflammatory pathways. High target selectivity and aqueous solubility. Capability...
Published: 11/13/2025   |   Inventor(s): Raymond (Ray) Dingledine, Radhika Amaradhi, Shabber Mohammed, Thota Ganesh
Keywords(s): Immunology and Inflammation Treatments, Neurology and Pain Treatments, Oncology Treatments, Small Molecule, Women's Health
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
MKK3/MYC Protein-Protein Interaction Inhibitor Overcomes Resistant Non-Small Cell Lung Cancer
Application A therapeutic use for SGI-1027 in the treatment of Osimertinib-resistant non-small cell lung cancer (NSCLC). Key Benefits The MKK3/MYC protein-protein interaction inhibitor SGI-1027 effectively decreases MYC levels in Osimertinib-resistant NSCLC cell lines. The combination of SGI-1027 with Osimertinib offers synergistic benefits over...
Published: 10/15/2025   |   Inventor(s): Andrey Ivanov, Haian Fu, Shi-Yong Sun, Zhen Chen
Keywords(s): Drug Discovery, Oncology Treatments, Protein and Peptide Therapeutics
Category(s): TechPub Algolia > Therapeutics
Assessment of Tumor Response to Treatment Using Level Set Clustering in PET Images
Application Tumor response algorithm that corrects for anatomical changes and robustly identifies local changes in serial PET images through a clustering algorithm. Key Benefits Robust to noise and outliers and can tolerate imperfections in data acquisition. Could be applicable to many other imaging modalities in radiation therapy. More accurately...
Published: 11/7/2025   |   Inventor(s): Timothy Fox, Eduard Schreibmann
Keywords(s): Medical Imaging (MRI, CT, Radiology), Oncology Treatments
Category(s): TechPub Algolia > Medical Device, TechPub Algolia > Software
Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease. Key Benefits Improved cellular uptake and protein suppression using antisense oligos. Longer ASO half-life compared to other ASO delivery methods. Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 9/22/2025   |   Inventor(s): Khalid Salaita, Radhika Sharma
Keywords(s): Biomaterials, Cardiology and Vascular Devices, Chemistry, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Micro and Nanotechnology
Optimizing the Engineering of CAR-T Cells
Application A method for selecting distinct T cell populations in order to generate more effective CAR-T cells. Key Benefits The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells. This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 2/13/2025   |   Inventor(s): Byron Au-Yeung
Keywords(s): Cell Therapy, Oncology Treatments, Production Methods
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Indolium 1 for Advanced Melanoma Treatment
Application A small molecule compound for the treatment of melanoma. Key Benefits Novel small molecule compound for the treatment of resistant melanoma. Well tolerated in vivo. Market Summary Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 7/22/2025   |   Inventor(s): Jack Arbiser
Keywords(s): Oncology Treatments, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers. The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 11/12/2025   |   Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
Keywords(s): Oncology Treatments, Pediatrics, Platform
Category(s): TechPub Algolia > Drug Discovery
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