Search Results - oncology+treatments

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Engineering Asymmetrically Glycosylated IgG Antibodies
Application A novel method to develop asymmetrically glycosylated therapeutic monoclonal IgG antibodies for preventing and treating diseases like cancer, infectious diseases, and autoimmune disorders. Key Benefits Different IgG antibody glycoforms can be produced, each with its unique effector functions and biological and therapeutic effects. Potential...
Published: 5/30/2025   |   Inventor(s): Eric J. Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibodies, Immunology and Inflammation Treatments, Microbiology and Infectious Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
IgG-Specific Enzymes with Reduced Residual Glycan Hydrolysis
Application Novel enzymes for IgG-specific glycosynthesis. Key Benefits Nearly full glycosylation of IgG antibodies. Improved antibody-mediated effector function properties. No measurable residual hydrolysis activity. Market Summary The global monoclonal antibodies market is experiencing significant growth due to the rising prevalence of chronic...
Published: 5/30/2025   |   Inventor(s): Eric J. Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibodies, Cardiovascular Treatments, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Research Tools
Assessment of Tumor Response to Treatment Using Level Set Clustering in PET Images
Application Tumor response algorithm that corrects for anatomical changes and robustly identifies local changes in serial PET images through a clustering algorithm. Key Benefits Robust to noise and outliers and can tolerate imperfections in data acquisition. Could be applicable to many other imaging modalities in radiation therapy. More accurately...
Published: 2/13/2025   |   Inventor(s): Timothy Fox, Eduard Schreibmann
Keywords(s): Medical Imaging (MRI, CT, Radiology), Oncology Treatments
Category(s): TechPub Algolia > Medical Device, TechPub Algolia > Software
Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease. Key Benefits Improved cellular uptake and protein suppression using antisense oligos. Longer ASO half-life compared to other ASO delivery methods. Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 5/30/2025   |   Inventor(s): Khalid Salaita, Radhika Sharma
Keywords(s): Biomaterials, Cardiology and Vascular Devices, Chemistry, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Micro and Nanotechnology
Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML). Key Benefits Unique dual-action functionality as a microtubule and MDM2 inhibitor. Successful inhibition of MDM2, an oncogene...
Published: 2/13/2025   |   Inventor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
Keywords(s): Cell Lines and Organoids, Hematology and Blood Products, Oncology Treatments, Repurposed Drug
Category(s): TechPub Algolia > Drug Discovery
Optimizing the Engineering of CAR-T Cells
Application A method for selecting distinct T cell populations in order to generate more effective CAR-T cells. Key Benefits The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells. This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 2/13/2025   |   Inventor(s): Byron Au-Yeung
Keywords(s): Cell Therapy, Oncology Treatments, Production Methods
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Indolium 1 for Advanced Melanoma Treatment
Application A small molecule compound for the treatment of melanoma. Key Benefits Novel small molecule compound for the treatment of resistant melanoma. Well tolerated in vivo. Market Summary Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 3/28/2025   |   Inventor(s): Jack Arbiser
Keywords(s): Oncology Treatments, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers. The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 3/28/2025   |   Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
Keywords(s): Oncology Treatments, Pediatrics, Platform
Category(s): TechPub Algolia > Drug Discovery
Markers Predictive of Therapeutic Response in B-cell Malignancies
Application Test to detect NF-kB2 breaks to guide treatment with proteasome inhibitors and its use with other therapeutic agents. Key Benefits Improved the prediction model to determine which patients are more likely to respond to bortezomib treatment. Improved the efficacy of treatment for patients with multiple myeloma and lymphomas. Market...
Published: 3/28/2025   |   Inventor(s): Leon Bernal-Mizrachi
Keywords(s): Biomarkers, Oncology Treatments
Category(s): TechPub Algolia > Diagnostics
Vaccines and Antibody Therapeutics for HPV-related Cancers
Application Treatment and prevention of HPV-induced malignancies. Key Benefits Identification of a protein expressed in a large number of HPV-induced cancers. Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells. The antibodies can be used to develop new treatments and vaccines...
Published: 3/28/2025   |   Inventor(s): Rafi Ahmed, Andreas Wieland
Keywords(s): Biologics, Microbiology and Infectious Disease Treatments, Oncology Treatments, Preventive Vaccines
Category(s): TechPub Algolia > Therapeutics
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