Search Results - pediatrics

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Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet (UCLA Case No. 2025-006)
UCLA researchers from the Department of Integrative Biology & Physiology have identified specific components of ketogenic diets that alter the microbiome and improve seizure resistance, providing valuable data to optimize diet treatments for refractory epilepsy. BACKGROUND: Refractory epilepsy, a disease characterized by uncontrolled seizures,...
Published: 9/19/2024   |   Inventor(s): Elaine Hsiao
Keywords(s): diet, dietary fiber, Epilepsy, gut, gut-brain axis, ketogenic diet, microbiome, pediatrics, seizure
Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology
Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
Application A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents. Key Benefits Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults. Allows the subjective assessment of the...
Published: 7/30/2024   |   Inventor(s): Sheila Angeles-Han
Keywords(s): Pediatrics, Research Study Tools, Sensory Organs/Ophthalmology
Category(s): TechPub Algolia > Research Tools
Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers. The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 8/22/2024   |   Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
Keywords(s): Oncology, Pediatrics, Platform
Category(s): TechPub Algolia > Drug Discovery
RSV Vaccine for Infants and Children
Application Vaccine for Respiratory Syncytial Virus (RSV) in infants and children. Key Benefits A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants. Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease. Potential to...
Published: 7/30/2024   |   Inventor(s): Larry Anderson, Binh Ha, Heying Sun
Keywords(s): Microbiology/Infectious Diseases, Pediatrics, Respiratory
Category(s): TechPub Algolia > Vaccines
Non-invasive Probes to Determine Efficacy of Cancer Therapies
Application A real-time, non-invasive probe to determine the efficacy of cancer immunotherapies. Key Benefits Determines immunotherapy success in patients. CAR cells can be tested before putting it back in the patients. Simple diagnostic with readout in 30 minutes compared to 2-3 days. Market Summary Lymphoblastic leukemia is one of the most...
Published: 7/30/2024   |   Inventor(s): Anna Kellner, Khalid Salaita, Curtis Henry
Keywords(s): Oncology, Pediatrics
Category(s): TechPub Algolia > Diagnostics
Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy. Key Benefits A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen The model can also be incorporated into future therapeutic...
Published: 7/30/2024   |   Inventor(s): William Hu, Sumit Verma
Keywords(s): Biomarker, Musculoskeletal, Pediatrics, Rare/Orphan Diseases
Category(s): TechPub Algolia > Diagnostics
Vision Test for Non-Verbal Children
Application Vision testing for non-verbal children, the hearing impaired, and non English-speaking population. Key Benefits Simplifies vision testing for non-verbal children. Does not require any verbal communication to be used effectively. Technical Summary While traditional eye charts are often effective, they rely on verbal communication...
Published: 7/30/2024   |   Inventor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
Keywords(s): Pediatrics, Sensory Organs/Ophthalmology
Category(s): TechPub Algolia > Diagnostics
3D Model for Analysis and Treatment Planning of Vascular Disease
Application A patient-specific, 3D model of pulmonary atresia for surgical planning. Key Benefits Patient-specific model. Allows for accurate surgical planning. Enables new anastomosis procedure. Market Summary Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 7/30/2024   |   Inventor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
Keywords(s): Cardiovascular, Hospital and Surgery, Pediatrics, Rare/Orphan Diseases
Category(s): TechPub Algolia > Software, TechPub Algolia > Diagnostics
Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 7/30/2024   |   Inventor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
Keywords(s): Antibody, Cell/Gene Therapy, Oncology, Pediatrics
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
Infant Pericardiocentesis Trainer for use of Ultrasound
The Problem:Pericardiocentesis is the definitive emergency treatment for tamponade. However, it remains a challenge for trainees because of the infrequent exposure to invasive neonatal and pediatric procedures. This technique can lead to serious complications if not performed correctly, including cardiac perforation and arrhythmia.The Technology:...
Published: 1/11/2023   |   Inventor(s): Jonathan Spagnoli, Ranjit Philip, Sandeep Chilakala, Jarrod Young
Keywords(s): Pediatrics
Category(s): Human Health
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