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Search Results - erik+dreaden
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Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application Novel reagents for manufacturing of CAR T cells with improved characteristics. Key Benefits A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy. Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 8/22/2024
|
Inventor(s):
Sarwish Rafiq
,
Erik Dreaden
,
A K M Nawshad Hossian
,
Biaggio Uricoli
Keywords(s):
Oncology
,
Platform
Category(s):
TechPub Algolia > Micro and Nanotechnology
Immune Cell Redirecting Therapies
Application A therapeutic against B cell cancers developed using a novel screening method for rapid drug discovery. Key Benefits Screening approach can be used for future drug discovery. Therapeutic incorporates cytokine therapy with reduced risk of off-target toxicity. Therapeutic is of interest for the treatment of B cell cancers and autoimmune...
Published: 10/28/2024
|
Inventor(s):
Erik Dreaden
,
Priscilla Do
,
Curtis Henry
,
Christopher Porter
Keywords(s):
Oncology
Category(s):
TechPub Algolia > Therapeutics
Photocaged Cytokines for Cancer Immunotherapy
Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells...
Published: 7/30/2024
|
Inventor(s):
Erik Dreaden
,
Lacey Perdue
,
Priscilla Do
Keywords(s):
Biologic
,
Enzyme/Protein
,
Immunology/Inflammation
,
Oncology
Category(s):
TechPub Algolia > Therapeutics