Search Results - jonathan+du

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Method for Identifying and Optimizing the Development of Heterodimeric Monoclonal Antibodies
Application Method to generate IgG heterodimers that can be used to generate bi-specific monoclonal antibodies for disease treatment. Key Benefits A novel method of screening and developing novel IgG heterodimers used for generating monoclonal antibodies for many diseases. Preliminary data demonstrate efficient production of IgG heterodimers that...
Published: 8/22/2024   |   Inventor(s): Eric Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibody, Immunology/Inflammation, Metabolic Diseases, Microbiology/Infectious Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
Engineering Asymmetrically Glycosylated IgG Antibodies
Application A novel method to develop asymmetrically glycosylated therapeutic monoclonal IgG antibodies for preventing and treating diseases like cancer, infectious diseases, and autoimmune disorders. Key Benefits Different IgG antibody glycoforms can be produced, each with its unique effector functions and biological and therapeutic effects. Potential...
Published: 7/30/2024   |   Inventor(s): Eric Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibody, Immunology/Inflammation, Microbiology/Infectious Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application Protein-based therapeutics for the treatment of IgG-mediated diseases. Key Benefits A new class of endoglycosidases for the treatment of IgG-mediated diseases. Four novel compounds have been developed that exhibited robust in vitro activity. Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 8/22/2024   |   Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
Keywords(s): Enzyme/Protein, Immunology/Inflammation, Metabolic Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics