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Search Results - biologics
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IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 4/1/2025
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Inventor(s):
Adam Waickman
,
Adam Wegman
Keywords(s):
antibody
,
antibody therapy
,
biologics
,
biomedical
,
disease prevention
,
immunotherapy
,
monoclonal antibody
,
Technologies
,
viral immunology
,
viral pathogenesis
Category(s):
Technology Classifications > Therapeutics and Vaccines
,
Technology Classifications > Antibodies
,
Technology Classifications > Healthcare
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Technology Classifications > Viral Vectors
,
Campus > Upstate Medical University
MVA and DNA Based SARS-CoV-2 Vaccines
Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 2/13/2025
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Inventor(s):
Rama Rao Amara
,
Sailaja Gangadhara
Keywords(s):
Biologics
,
COVID19
,
DNA and RNA Vaccines
,
Immunology and Inflammation Treatments
,
Microbiology and Infectious Disease Treatments
Category(s):
TechPub Algolia > Vaccines
Vaccines and Antibody Therapeutics for HPV-related Cancers
Application Treatment and prevention of HPV-induced malignancies. Key Benefits Identification of a protein expressed in a large number of HPV-induced cancers. Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells. The antibodies can be used to develop new treatments and vaccines...
Published: 3/28/2025
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Inventor(s):
Rafi Ahmed
,
Andreas Wieland
Keywords(s):
Biologics
,
Microbiology and Infectious Disease Treatments
,
Oncology Treatments
,
Preventive Vaccines
Category(s):
TechPub Algolia > Therapeutics
A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market...
Published: 2/28/2025
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Inventor(s):
Malathy (mala) Shanmugam
,
Richa Bajpai
Keywords(s):
Biologics
,
Biomarkers
Category(s):
TechPub Algolia > Diagnostics
Photocaged Cytokines for Cancer Immunotherapy
Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells...
Published: 3/28/2025
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Inventor(s):
Erik Dreaden
,
Lacey Perdue
,
Priscilla Do
Keywords(s):
Biologics
,
Enzyme and Protein Research
,
Immunology and Inflammation Treatments
,
Oncology Treatments
Category(s):
TechPub Algolia > Therapeutics
Live Attenuated Zika Virus Vaccines
Application Yellow fever virus-based live attenuated Zika virus (ZIKV) vaccines. Key Benefits Reduces neurotropism from Zika virus. High safety and immunogenicity of chimeric vaccines. Market Summary Zika virus (ZIKV) belongs to the flavivirus family of viruses, which include West Nile (WN), Japanese encephalitis (JE), yellow fever (YF), dengue...
Published: 2/13/2025
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Inventor(s):
Baek Kim
Keywords(s):
Biologics
,
Microbiology and Infectious Disease Treatments
,
Preventive Vaccines
Category(s):
TechPub Algolia > Vaccines
Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries. Key Benefits Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries. Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 2/13/2025
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Inventor(s):
Ahsan Husain
,
Nawazish Naqvi
Keywords(s):
Biologics
,
Cardiovascular Treatments
,
Repurposed Drug
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 3/28/2025
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Inventor(s):
Malathy (mala) Shanmugam
,
Richa Bajpai
Keywords(s):
Biologics
,
Biomarkers
,
Drug Target Identification
Category(s):
TechPub Algolia > Diagnostics
,
TechPub Algolia > Therapeutics
,
TechPub Algolia > Drug Discovery
Bacteria Strain in Probiotic Formulation for Weight Control
Application Bacterial strain from Lactococcus lactis as a potential dietary supplement or therapeutic to help weight control and control gut inflammation. Key Benefits Provides anti-inflammatory effects in the intestine. Improves weight control and protects against fatty liver disease in mice fed a high fat and high sugar Western-style diet. This...
Published: 3/28/2025
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Inventor(s):
Rheinallt M. Jones
,
Trevor Darby
Keywords(s):
Biologics
,
Gastroenterology Treatments
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Immunology and Inflammation Treatments
,
Nutraceuticals and Supplements
Category(s):
TechPub Algolia > Therapeutics
IFN Gamma Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
Application Mesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation. Key Benefits Preserves the immunosuppressive function of MSCs following thawing. Improves effectiveness of transplanted MSCs following cryopreservation. Market Summary Mesenchymal...
Published: 2/13/2025
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Inventor(s):
Jacques Galipeau
,
Raghavan Chinnadurai
Keywords(s):
Biologics
,
Cell Therapy
,
Enzyme and Protein Research
,
Immunology and Inflammation Treatments
Category(s):
TechPub Algolia > Therapeutics
,
TechPub Algolia > Research Tools
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