Brief Description: The present disclosure provides methods of producing a modified immune cell responsive to orthogonal cytokine signaling and a modified immune cell produced by said method. The present disclosure further provides a modified immune cell responsive to orthogonal cytokine signaling and methods for treating cancer comprising the modified immune cell. Intellectual Property Title: Intellectual Property: Intellectual Property: US2023-0364238A1 Docket Number: Docket#: 22-10028 Reference Media Title: Reference Media: