Search Results - monoclonal+antibody

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Fully Human Antibodies and Antibody Drug Conjugates Targeting CD276 (B7-H3) for the Treatment of Cancer
Abstract: Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. Angiogenesis occurs during normal growth and development, where it is known as physiological angiogenesis, and during the growth of solid tumors, where it is known as pathological angiogenesis. CD276, also known as B7-H3, is a cell surface tumor endothelial...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Brad St. Croix, Steven Seaman, Saurabh Saha, Xaioyan Zhang, Dean Welsch, Gary Decrescenzo
Keywords(s): Antibody Drug Conjugate (ADC), B7-H3, CANCER, CD276, Dimitrov, immuno-oncology, Immunotherapy, Monoclonal Antibody
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Human Monoclonal Antibodies Cross-reacting to Insulin-like Growth Factors IGF-I and IGF-II as Potential Anti-tumor Agents
Abstract: The National Cancer Institute's  Cancer and Inflammation Program is seeking statements of capability or interest from parties interested in licensing this technology.  The type 1 insulin-like growth factor (IGF) receptor (IGF1R) is over-expressed by many tumors and mediates proliferation, motility, and protection from apoptosis. Agents that...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Qi Zhao, Zhongyu Zhu
Keywords(s): Dimitrov, IGF-I, IGF-II, insulin-like growth factor, Monoclonal Antibody
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Development of Next Generation Antibody Drug Conjugates (ADCs) Against CD276
Abstract: Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. Angiogenesis occurs during normal growth and development (physiological angiogenesis) and during the growth of solid tumors (pathological angiogenesis). CD276, also known as B7-H3, is a cell surface tumor endothelial marker that is highly expressed in the tumor...
Published: 5/22/2024   |   Inventor(s): Brad St. Croix, Yang Feng, Steven Seaman
Keywords(s): ADC, antibody drug conjugate, B7-H3, CD276, Immunotherapy, Monoclonal Antibody, St. Croix
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Antibodies and CARs Targeting FLT3 for the Treatment of Acute Myeloid Leukemia and Acute Lymphoid Leukemia
Abstract: Fms-like tyrosine kinase 3 (FLT3) is a cytokine receptor which belongs in the receptor tyrosine kinase class III.  FLT3 is expressed on the surface of many hematopoietic progenitor cells and plays an important role in hematopoietic stem/progenitor cell survival and proliferation.  It is often overexpressed in acute lymphoblastic leukemia (ALL)...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen, Terry Fry, Christopher Chien, Haiying Qin
Keywords(s): acute lymphocytic leukemia, acute myeloid leukemia, ALL, AML, CANCER, cancer therapeutic, chimeric antigen receptor (CAR), Flt3, Monoclonal Antibody
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
A Human Monoclonal Antibody Against Deacetylated PNAG for Use as an Antimicrobial Agent
Abstract: Biofilms are complex microbial communities, surface attached and held together by self-produced polymer matrices.  These matrices are mainly composed of polysaccharides, secreted proteins and nucleic acids.  Poly-N-acetyl glucosamine (PNAG) is a highly conserved surface polysaccharide expressed by a range of bacterial, fungal and protozoan...
Published: 5/22/2024   |   Inventor(s): Jeffrey Gildersleeve, Joel Temme
Keywords(s): ANTIMICROBIAL, Biofilm, Deacetyleated Poly-N-Acetyl Glucosamine, dPNAG, Gildersleeve, Mab, Monoclonal Antibody, TG10
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 7/11/2023   |   Inventor(s): Adam Waickman, Adam Wegman
Keywords(s): antibody, antibody therapy, biologics, biomedical, disease prevention, immunotherapy, monoclonal antibody, Technologies, viral immunology, viral pathogenesis
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies, Technology Classifications > Healthcare, Technology Classifications > Viral Vectors, Campus > Upstate Medical University
Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme
Available for licensing are monoclonal antibodies targeting human DNA polymerase beta (Pol B). Pol B is a constitutively expressed "housekeeping" enzyme that plays a role in base excision repair (BER), a cellular defense mechanism that repairs DNA base damage and loss. Aberrant Pol B expression is associated with genomic instability indicating that...
Published: 7/25/2024   |   Inventor(s): Rajendra Prasad, Samuel Wilson
Keywords(s): AC5XXX, ACXXXX, ANTIBODY, AXXXXX, CC2XXX, CCXXXX, CDXXXX, CXXXXX, DNA, DNA polymerase, DNA polymerase beta, monoclonal, Monoclonal Antibody, monoclonal antibody based assays, polymerase
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Antibodies Against TL1A, a TNF-Family Cytokine, for the Treatment and Diagnosis of Autoimmune Inflammatory Diseases
Autoimmune inflammatory diseases occur in greater than five percent of the United States population; this disease group includes asthma, multiple sclerosis, rheumatoid arthritis, and lupus. Treatments generally include immunosuppressants or anti-inflammatory drugs, which can have serious side effects; recently, more specific immunomodulatory therapies...
Published: 7/30/2024   |   Inventor(s): Francoise Meylan, Yun-Jeong Song, Richard Siegel
Keywords(s): antibodies, ANTIBODY, ANTI-HUMAN, Anti-mouse, Autoimmune, diagnostic, DR3, IA3XXX, IAXXXX, IB3XXX, IBXXXX, Immunomodulation, immuno-modulator, immunomodulatory, INFLAMMATORY, inflammatory disease, IXXXXX, monoclonal, Monoclonal Antibodies, Monoclonal Antibody, Patent Category - Biotechnology, therapeutic, TL1A, tnf, TNFRSF25, TNFSF15, tumor necrosis factor, USES
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Immunology
A STRATEGY FOR CREATING VACCINES TO ELICIT ANTIBODIES TARGETING A SPECIFIC EPITOPE
A STRATEGY FOR CREATING VACCINES TO ELICIT ANTIBODIES TARGETING A SPECIFIC EPITOPE Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed PMD (Protect, Modify, Deprotect), an immunofocusing strategy that can be used in vaccine development for the generation of antibodies targeting a specific epitope. Vaccine development...
Published: 3/17/2023   |   Inventor(s): Payton Weidenbacher, Peter Kim
Keywords(s): Antibody, Epitope Shield, Immunofocusing, mAb, Monoclonal Antibody, Vaccine
Category(s): Technology Classifications > Biology
Antibodies and ELISA for Chondroitinase ABC
ELISA Determines ChABC Distribution and Content in Tissues and Bodily FluidsChondroitinase ABC (ChABC) is a bacterial enzyme that degrades sugar chains attached to the core protein of chondroitin sulfate proteoglycans (CSPGs). CSPGs are involved in a variety of biological processes in higher organisms, including humans. ChABC has a well-known potential...
Published: 7/12/2022   |   Inventor(s): David Muir
Keywords(s): Antibody, Chondroitinase, Hybridoma, Immunochemistry, Monoclonal, Monoclonal Antibody, Research
Category(s): Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others