Search Results - chemotherapy

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Neuro-Behavioral Assay for Physiological Evaluation of Water-Soluble Anesthetics
Background The development and use of general anesthetics is a key aspect of modern medicine. However, the current reliance on lipid-soluble general anesthetics presents issues, particularly for elderly patients who often have increased adipose tissue and decreased body water. This demographic can respond poorly to lipid-soluble anesthetics, resulting...
Published: 9/10/2024   |   Inventor(s): Gunther Zupanc, David Lehotzky
Keywords(s): Anesthesiology, Assays, Chemotherapy, Drug Discovery & Development, High Throughput Screening
Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Drug Discovery
Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)
UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...
Published: 1/17/2024   |   Inventor(s): Serendipity Zapanta Rinonos, Albert Lai
Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology
Increased Therapeutic Effectiveness of PE-Based Immunotoxins
Abstract: Patients receiving immunotoxin cancer therapy are less likely to experience the deleterious side-effects associated with non-discriminate therapies such as chemotherapy or radiation therapy. Unfortunately, the continued administration of immunotoxins often leads to a reduced patient response due to the formation of neutralizing antibodies...
Published: 5/21/2024   |   Inventor(s): Ira Pastan, Masanori Onda, Wenhai Liu
Keywords(s): B-CELL, CHEMOTHERAPY, Human B cell epitopes, Immunogenic epitopes, Immunotoxin, Pseudomonas exotoxin A, T-cell
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Enhanced Cancer Chemotherapy Using the Bioactive Peptide Recifin And Its Analogues
Abstract: Topoisomerase enzymes play an important role in cancer progression by controlling changes in DNA structure through catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle. Therefore, topoisomerases are important targets for cancer chemotherapy. Many topoisomerase 1 (TOP1) inhibitors...
Published: 4/8/2024   |   Inventor(s): Barry O'Keefe, Lauren Krumpe, Johan Rosengren, Ingrid Schroeder, Alan Bermingham, Christophe Marchand, Kirk Gustafson, Brice Wilson, Yves Pommier
Keywords(s): CANCER, Chemosensitizing Agents, CHEMOTHERAPY, Cyclic Peptide, Irinotecan TOP1, O’Keefe, Recifin, Tdp1, Topoisomerase 1 inhibitors, Topotecan, Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics
Angiogenesis-Based Cancer Therapeutic
Abstract: Vascular Endothelial Growth Factor-A (VEGF-A) is an angiogenic agent that drives blood vessel formation in solid tumors and other diseases, such as macular degeneration and diabetic retinopathy. Several therapies that target the ability of VEGF to stimulate angiogenesis have been approved. These therapies regulate VEGF-A activity by binding...
Published: 4/8/2024   |   Inventor(s): Donald Bottaro, Fabiola Cecchi
Keywords(s): ANGIOGENESIS, CHEMOTHERAPY, Diabetic Retinopathy, FLT-1, Heparin sulfate proteoglycan, Hepatocyte growth factor (HGF), KDR/FLK-1, Macular degeneration, VEGF-A
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Consistent and enhanced production of anti-cancer drugs from the Madagascar periwinkle plant
INV-19070 Background The Madagascar periwinkle plant has been used for vinblastine (VBL) and vincristine (VCR) since the 1960s. These chemical compounds have been listed on “World Health Organization’s Model List of Essential Medicines”. However, due to high cost, low concentration in extracts, and unpredictable supply, the applications...
Published: 9/10/2024   |   Inventor(s): Carolyn Lee-Parsons, Elisa Peter, Samuel Mortensen
Keywords(s): Agriculture/Horticulture, Chemotherapy, Manufacturing, Process, Renewable
Category(s): Technology Classifications > 1. Life Science > Therapeutics, Chemistry, Technology Classifications > 1. Life Science > Green Chemistry, Technology Classifications > 1. Life Science > Drug Discovery
Cyclin C and its role in cancer and cancer therapeutics
Cancer is a leading cause of death worldwide with more than 14 million new patients diagnosed and almost 9 million deaths every year. Despite increasing survival rates over the past few decades, current treatments such as radiation, chemotherapy, targeted therapies and new immunotherapies still fail in large subsets of patients. Mounting drug resistance...
Published: 3/13/2024   |   Inventor(s): Randy Strich, Katrina Cooper
Keywords(s): Apoptosis, Cancer, Chemotherapy, Cyclin C, Radiation, Synergy, Therapeutic
Category(s): Human Health Care > Therapeutics
Macrophage-Targeted Multi-Compartmental Delivery Systems
INV-1028 Background Macrophages are important immune cells in the body that regulate different biological processes involved in inflammatory and infectious diseases. Macrophages originate from the mononuclear phagocyte system (MPS) in the bone marrow. The MPS system comprises of monocytes and tissue, it matures into a larger phagocytic cell called...
Published: 9/10/2024   |   Inventor(s): Mansoor Amiji, Husain Attarwala, Shardool Jain, Mayur Kalariya
Keywords(s): Biotech, Breast Cancer, Cancer, Chemotherapy, Drug Delivery, Drugs, Health, Medical, Nanomedicine
Category(s): -Biomedical Materials, -Health, -Nanomedicine, -Cancer, Technology Classifications > 1. Life Science > Drug Delivery