Search Results - viral+infection

5 Results Sort By:
An Alternative T Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2024-198)
UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have created a novel T cell redirecting bispecific antibody (TRBA) for treatment of cytomegalovirus (CMV) infection. BACKGROUND: The human cytomegalovirus (CMV) has a seroprevalence of about 60% in the USA and nearly 100% of the population in some parts of the world....
Published: 11/15/2024   |   Inventor(s): Otto Yang
Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), immunocompromised patients, Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Transplant, Viral infection
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy
A T-Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2023-020)
UCLA researchers at the Departments of Medicine and Microbiology Immunology and Molecular Genetics have developed a novel bispecific antibody-based immunotherapy strategy for the treatment of Cytomegalovirus infections. BACKGROUND: The human cytomegalovirus (CMV) is a widespread virus estimated to infect 60% of American adults and nearly 100% of...
Published: 11/15/2024   |   Inventor(s): Otto Yang
Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Viral infection
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy
Topoisomerase III (TOP3) Inhibitors as Antiviral and Anticancer Compounds based on Bisacridines
Abstract: Topoisomerase 3B (TOP3B) is the only topoisomerase that can act on RNA as well as DNA. Thus, it is a target of interest for the development of cancer therapies and RNA viral infection therapies. TOP3B is not an essential gene for carcinogenesis, but a subset of cancer cells with pre-existing genome instability are particularly vulnerable to...
Published: 12/18/2024   |   Inventor(s): Yves Pommier, Sourav Saha, Wenjie Wang, Shar-yin Huang
Keywords(s): Bisacridines, CANCER, Pommier, SARS-CoV-2, TOP, TOP3, TOP3 Inhibitor, TOPOISOMERASE, Topoisomerase III, Topoisomerase Inhibitor, viral infection
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
A Viral Exposure Signature to Define and Detect Early Onset Hepatocellular Carcinoma
Abstract: Early detection of liver cancer, such as hepatocellular carcinoma (HCC), is key to improve cancer-related mortality. More than 800,000 people are diagnosed with this cancer each year throughout the world. Liver cancer is also a leading cause of cancer deaths worldwide, accounting for more than 700,000 deaths each year. Currently, millions...
Published: 4/8/2024   |   Inventor(s): Xin Wei Wang, Jinping Liu, Wei Tang
Keywords(s): Biomarker, HCC, hepatocellular carcinoma, Liver cancer, viral infection, Wang
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics
Topoisomerase III (TOP3) Inhibitors and Antiviral Compounds based on Cyanine Dyes
Topoisomerase 3B (TOP3B) is the only topoisomerase that can act on RNA as well as DNA, and thus has been a target of interest for the development of cancer therapies and RNA viral infection therapies. In the context of cancer, TOP3B is not an essential gene, but a subset of cancer cells with pre-existing genome instability are particularly vulnerable...
Published: 12/18/2024   |   Inventor(s): Yves Pommier, Shar-yin Huang, Wenjie Wang, Weidong Wang, Sourav Saha, Tianyi Zhang, Mariano Garcia-Blanco, Pei-Yong Shi, Yuk-Ching Tse-Dinh, Debbie Kennedy-Boone
Keywords(s): CANCER, Cyanine Dye, NIA, Pommier, SARS-CoV-2, TOP, TOP3, TOP3 Inhibitor, TOPOISOMERASE, Topoisomerase III, Topoisomerase Inhibitor, viral infection, Wang
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology