Search Results - bioanalysis

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Single Cell In-Situ Extraction with Intact 3D Morphology from Formalin Fixed Paraffin Embedded (FFPE) Tissues
FFPE is a well-established and widely used method for preservation and histological analysis of tissue samples. DNA/RNA/and Proteins can be extracted from FFPE samples, but generally lack single cell resolution and completely lack 3D spatial resolution. Enabling 3D resolution allows the correlation of morphology to information like gene expression,...
Published: 4/25/2023   |   Inventor(s): David Richardson, Thai Tran, Dmitry Derkach, Colleen Ziegler
Keywords(s): Bioanalysis, Biological Cell Manipulation, Bio-Technology, Cancer, Device, Diagnostics, Gene Expression, Genomics, Proteomics, In situ, Molecular Diagnostics, Single-cell analysis
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Type 1 Diabetes Biomarkers
Type 1 Diabetes (T1D) is one of the most common juvenile autoimmune diseases and is characterized by progressive destruction of pancreatic ß-cells. By the time of T1D diagnosis, around 70-90% of pancreatic ß-cells are already dead. T1D patients face many potential health complications and co-morbidities which lead to both personal and societal...
Published: 2/23/2023   |   Inventor(s): Joshua LaBaer, Ji Qiu, Xiaofang Bian, Desmond Schatz, Clive Wasserfall, Mark Atkinson
Keywords(s): Autoantibody, Bioanalysis, biomarker, Detection, Diabetes, Diagnostics, Early Detection, ELISA, Screening
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Tri-Color DualGlucose and Oxygen Sensors
Glucose and oxygen are important components of human metabolic processes -- many diseases are associated with glucose transport and metabolic disorders including diabetes and cancer. Monitoring glucose and cell metabolism can provide invaluable information for understanding these diseases. There are many assays and sensors for both glucose and oxygen,...
Published: 2/23/2023   |   Inventor(s): Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer
Keywords(s): Agriculture and Animal Science, Bioanalysis, Bio-Technology, Fluorescence, Materials, Medical Devices and Imaging, Sensors
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Life Science (All LS Techs), Medical Diagnostics/Sensors
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Noninvasive Tear Stress Sensors
Chronic stress has been widely implicated in a plethora of lethal and life-altering diseases including diabetes, heart attacks, depression, Alzheimer's and osteoporosis. Thus, there is great interest in monitoring stress levels in the population. Stress has both biochemical and physiological effects on the body that can be quantified in bodily fluids....
Published: 2/23/2023   |   Inventor(s): Jeffrey LaBelle, Tina Hakimi, Brittney Cardinell
Keywords(s): Antibodies, Bioanalysis, Bioassay, Cancer, Cardiovascular, Detection, Diabetes, Diagnostics, Health Monitoring, Sensors
Category(s): Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Life Science (All LS Techs)
Novel Antibodies for Detecting Gastric Cancer
Gastric cancer (GC) is a major public health problem in many countries, with more than 1 million new cases, worldwide, in 2018, contributing to almost 800,000 deaths. And new research suggests that GC may be on the rise in the US, particularly among younger adults. Early detection of GC often allows for greater therapeutic options, however, because...
Published: 2/23/2023   |   Inventor(s): Joshua LaBaer, Ji Qiu, Lusheng Song, Yunro Chung
Keywords(s): Antibodies, Antibody Therapeutics, Bioanalysis, Bioassay, Cancer, Diagnostics, Immunosignature, Infectious Disease, Protein Assays
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Two-Photon Laser Lithography for Fabrication of XFEL Sample Injectors
X-ray Free Electron Lasers (XFEL) are a valuable tool for determining the structure of biological macromolecules. Obtaining accurate results necessitates solvation of the sample in a specified chemical solution throughout the injection process. This solvation must not unduly compromise the vacuum environment or cleanliness of the XFEL scattering chamber....
Published: 2/23/2023   |   Inventor(s): R. Bruce Doak, Garrett Nelson
Keywords(s): Bioanalysis, Liquid Handling and Dispensing, Lithography, Micro-Fluidics, Nanostructure, Protein Assays
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Imaging, Physical Science, Physics