Search Results - deirdre+meldrum

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Methods to Increase Genetic Transformation in Cyanobacterium
Cyanobacteria are model species for studying photosynthesis and recently have been gaining increased attention for their ability to produce renewable fuels and chemicals by harvesting solar energy and recycling carbon dioxide. Unfortunately, despite all the recent research and exciting achievements made regarding cyanobacteria, genetic transformation...
Published: 4/14/2023   |   Inventor(s): Bo Wang, Weiwen Zhang, Deirdre Meldrum
Keywords(s): Algae, Microalgae, Cyanobacteria, Biofuels Production, Bio-Technology, Plasmid, Vectors, Constructs
Category(s): Life Science (All LS Techs), Vectors/Constructs/Plasmids, Alternative Energy/Biofuels/Bioplastics/Algae
Glucose, pH, and Oxygen Triple Sensor
Glucose, oxygen, and extracellular pH are important components of human metabolic processes -- many diseases are associated with glucose transport and metabolic disorders including diabetes and cancer. Monitoring glucose and cell metabolism can provide invaluable information for understanding these diseases. There are many assays and sensors for glucose,...
Published: 2/23/2023   |   Inventor(s): Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer, Clifford Anderson, Laimonas Kelbauskas, Kristen Lee
Keywords(s): Agriculture and Animal Science, Bio-Technology, Materials and Electronics, Medical Devices and Imaging
Category(s): Advanced Materials/Nanotechnology, Chemical/Biological Sensors, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Medical Diagnostics/Sensors
Tri-Color DualGlucose and Oxygen Sensors
Glucose and oxygen are important components of human metabolic processes -- many diseases are associated with glucose transport and metabolic disorders including diabetes and cancer. Monitoring glucose and cell metabolism can provide invaluable information for understanding these diseases. There are many assays and sensors for both glucose and oxygen,...
Published: 2/23/2023   |   Inventor(s): Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer
Keywords(s): Agriculture and Animal Science, Bioanalysis, Bio-Technology, Fluorescence, Materials, Medical Devices and Imaging, Sensors
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Life Science (All LS Techs), Medical Diagnostics/Sensors
Biocompatible gel formulation
Single-cell and cell cluster optical tomography, or Cell-CT, has found increasing application in life sciences basic research. Two limitations to its use in this area are that it can image only fixed cells, and the lack of thixotropic gels that can support live cells and also satisfy refractive index constraints. Researchers at the Biodesign Institute...
Published: 2/23/2023   |   Inventor(s): Roger Johnson, Fengyu Su, Laimonas Kelbauskas, Vivek Nandakumar, Yanqing Tian, Deirdre Meldrum
Keywords(s): Bio-Technology, Drug Screening, Materials, Medical Devices and Imaging, Therapeutics
Category(s): Biomaterials, Life Science (All LS Techs), Medical Imaging
Fluorescent Potassium Ion Sensors
The accurate measurement of potassium ion levels in biological samples is essential given the impact such ion levels have on many aspects of homeo-stasis. Normal potassium levels are important for the maintenance of heart and nervous system function. Traditionally, potassium ions have been measured in plasma or serum using ion-selective electrodes,...
Published: 2/23/2023   |   Inventor(s): Yanqing Tian, Deirdre Meldrum, Xianfeng Zhou, Fengyu Su, Roger Johnson, Cody Youngbull
Keywords(s): Agriculture and Animal Science, Bio-Technology, Environmental, Materials and Electronics, Medical Devices and Imaging, Therapeutics
Category(s): Medical Diagnostics/Sensors, Chemical/Biological Sensors, Life Science (All LS Techs)
Ratiometric optical dual oxygen and pH sensor with three emission colors
The efficiency of biofuel production depends on the photosynthetic activity of microbes; to maximize their growth it is necessary to continually monitor the environmental conditions. Traditional monitoring methods (such as using electrodes to measure CO2 consumption and/or O2 generation) are typically time- and labor-intensive, have low throughput,...
Published: 2/23/2023   |   Inventor(s): Yanqing Tian, Weiwen Zhang, Deirdre Meldrum, Hongguang Lu, Yuguang Jin, Mark Holl
Keywords(s): Agriculture and Animal Science, Bio-Technology, Cancer, Detection, Fluorescence, Hydrogels, Materials, Probe, Sensors, Synthesis
Category(s): Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Life Science (All LS Techs)
Endoscope for Analyte Consumption Rate Determination with Single Cell Resolution for In Vivo Applications
Determination of consumption/secretion rates of single-cell resolution has great potential for delivering detailed insights into early onset and development of various disease states as well as drug and stimulus response. Due the lack of sensitivity of current technologies, this information is difficult to obtain. Single cell measurements in vivo are...
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
Keywords(s): Bio-Technology, Drug Screening, Medical Devices and Imaging, Therapeutics
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Imaging
Single-cell QUantitative In Situ RT-PCR (SQUIRT-PCR)
Quantitative real-time PCR (qRT-PCR) is a well-established method for amplifying DNA using fluorescent probes. Traditionally this is a step-wise process where an aliquot of the DNA to be amplified is deposited in a chamber and amplified/measured in the chamber. Current systems require significant time for sample preparation including tissue disaggregation,...
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Shih-Hui (Joseph) Chao, Thai Tran, Laimonas Kelbauskas, Jeff Houkal, Andrew Hatch, Weimin Gao, David Richardson
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Quantitative, Multi-Target, Nucleic Acid Analysis Device
Loop-mediated isothermal amplification (LAMP) has great potential for sensitive and selective nucleic acid analysis in resource-limited settings. Amplifications can be easily observed via optical means such as colorimetry which combines robust performance and simple instrumentation. To date, microfluidic approaches based on colorimetric detection have...
Published: 2/23/2023   |   Inventor(s): Rhett Martineau, Jeff Houkal, Shih-Hui (Joseph) Chao, Weimin Gao, Shufang Ci, Deirdre Meldrum
Keywords(s): Agriculture and Animal Science, Bio-Technology, Educational, Environmental, Medical Devices and Imaging
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Chips and Fabrication Methods for Rotation of Live Single Cells or Cell Clusters in Live Cell Computed Tomography
High-dimensional single cell visualization technologies are redefining the way we view and understand biological systems, particularly when identifying and analyzing cancer cells. Some cell defects on the surface or in the interior of a cell just can't be properly evaluated in two dimensional microscopy. However, to completely visualize and quantitatively...
Published: 2/23/2023   |   Inventor(s): Hong Wang, Deirdre Meldrum, Rishabh Shetty, Laimonas Kelbauskas, Shih-Hui (Joseph) Chao
Keywords(s): Bio-Technology, Mechanical and Manufacturing, Medical Devices and Imaging
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs)
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