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Search Results - autoantibody
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COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES
COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES Researchers at CZ Biohub SF and UCSF have developed methods and kits to detect autoantibodies targeting the transcobalamin receptor CD320, which is associated with neurological symptoms in certain patients, as well as methods to treat patients with this condition. Vitamin...
Published: 10/26/2023
|
Inventor(s):
John Pluvinage
,
Michael Wilson
,
Joseph DeRisi
,
Samuel Pleasure
Keywords(s):
Autoantibody
,
Brain
,
Vitamin B12
Category(s):
Technology Classifications > Biology
Type 1 Diabetes Biomarkers
Type 1 Diabetes (T1D) is one of the most common juvenile autoimmune diseases and is characterized by progressive destruction of pancreatic ß-cells. By the time of T1D diagnosis, around 70-90% of pancreatic ß-cells are already dead. T1D patients face many potential health complications and co-morbidities which lead to both personal and societal...
Published: 2/23/2023
|
Inventor(s):
Joshua LaBaer
,
Ji Qiu
,
Xiaofang Bian
,
Desmond Schatz
,
Clive Wasserfall
,
Mark Atkinson
Keywords(s):
Autoantibody
,
Bioanalysis
,
biomarker
,
Detection
,
Diabetes
,
Diagnostics
,
Early Detection
,
ELISA
,
Screening
Category(s):
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Life Science (All LS Techs)
,
Proteomic Assays/Reagents/Tools
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy. Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 3/17/2023
|
Inventor(s):
Caleigh Mandel-Brehm
,
Joseph DeRisi
,
Mark Anderson
Keywords(s):
Antibody
,
Autoantibody
,
Autoimmune
,
Biomolecules
,
Diagnosis
,
IgG
,
Immunotherapy
,
Lipodystrophy
Category(s):
Technology Classifications > Biology
Biomarkers for Diagnosis of Lung Cancer
Lung cancer is the leading cause of cancer deaths in the United States, with more than 150,000 deaths in 2014. While the increased use of CT screening for lung cancer has resulted in a reduction in lung cancer mortality, it has also resulted in an increased detection of benign pulmonary nodules. Patients often undergo unnecessary, costly and invasive...
Published: 2/23/2023
|
Inventor(s):
Joshua LaBaer
,
Ji Qiu
,
Jie Wang
,
Garrick Wallstrom
,
Jin Park
,
William Rom
,
Harvey Pass
Keywords(s):
Autoantibody
,
Biomarker discovery
Category(s):
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Life Science (All LS Techs)
,
Medical Diagnostics/Sensors
,
Proteomic Assays/Reagents/Tools
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1 Researchers at UCSF and the Chan Zuckerberg Biohub have identified multiple common
autoantibody
targets in APS1 patients through proteome-wide programmable phage-display. The identification of autoantigens remains a critical challenge for understanding and treating autoimmune...
Published: 3/17/2023
|
Inventor(s):
Sara Vazquez
,
Mark Anderson
,
Joseph DeRisi
Keywords(s):
Antibody
,
Autoantibody
,
Diagnosis
,
Particle Display
,
Serum
Category(s):
Technology Classifications > Biology
Biomarkers for Early Detection of Serous Ovarian Cancer
Ovarian cancer is one of the most common cancers among women, with over 21,000 new cases and over 14,000 deaths per year. If detected early, the 5-year survival rate is over 80%, but that drops to just 11% if detected at stage IV, and over 60% of patients are diagnosed with advanced disease. Early detection is hampered by limitations in current biomarkers,...
Published: 2/23/2023
|
Inventor(s):
Benjamin Katchman
,
Karen Anderson
,
Garrick Wallstrom
,
Joshua LaBaer
,
Daniel Cramer
Keywords(s):
Antibodies
,
Autoantibody
,
Biomarker discovery
,
Cancer
,
Diagnostics
,
Early Detection
,
Immunosignature
,
Ovarian Cancer
Category(s):
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Life Science (All LS Techs)
,
Medical Diagnostics/Sensors
,
Proteomic Assays/Reagents/Tools
AUTOANTIBODIES AS BIOMARKER OF PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH TESTICULAR CANCER
AUTOANTIBODIES AS BIOMARKER OF PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH TESTICULAR CANCER Researchers at the Chan Zuckerberg Biohub, UCSF and the Mayo Clinic have discovered a novel biomarker for an autoimmune disease that affects patients with testicular cancer. The disease, known as “testicular cancer-associated paraneoplastic encephalitis,”...
Published: 3/17/2023
|
Inventor(s):
Joseph DeRisi
,
Michael Wilson
,
Caleigh Mandel-Brehm
,
Brian O'Donovan
,
Sean Pittock
,
Divyanshu Dubey
,
Thomas Kryzer
,
Vanda Lennon
,
Andrew McKeon
Keywords(s):
Antibody
,
Autoantibody
,
Diagnosis
,
KLHL11
,
Neurology
,
Testicular Cancer
Category(s):
Technology Classifications > Biology
Autoantibody
Biomarkers for Crohn’s Disease
Crohn’s disease (CD), is an inflammatory bowel disease that affects about 3 out of 1,000 people in the U.S. It is currently not known what causes CD, but hereditary, environmental factors and a dysregulated immune system are thought to play a role. Diagnosis of CD is difficult and often involves expensive imaging and invasive biopsies. Current...
Published: 10/19/2023
|
Inventor(s):
Joshua LaBaer
,
Ji Qiu
,
Haoyu Wang
,
Shabana Pasha
,
Jonathan Leighton
Keywords(s):
Antibodies
,
Autoantibody
,
biomarker
,
Biomarker discovery
,
Diagnostics
Category(s):
Life Science (All LS Techs)
,
Medical Diagnostics/Sensors
,
Proteomic Assays/Reagents/Tools
Identification of Biomarkers for Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects about 1% of the world population and is characterized by synovial inflammation and joint destruction. Anti-citrullinated protein antibodies (ACPA) have been detected specifically in RA patients and may provide utility in RA risk assessment and diagnosis. ACPA levels correlate with...
Published: 2/23/2023
|
Inventor(s):
Joshua LaBaer
,
Ji Qiu
,
Kailash Karthikeyan
,
Jane Buckner
,
Gerald Nepom
Keywords(s):
Antibodies
,
Autoantibody
,
Autoimmune Disorders
,
biomarker
,
Diagnostics
,
Protein array
Category(s):
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Life Science (All LS Techs)
,
Proteomic Assays/Reagents/Tools