Search Results - neal+woodbury

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Mapping Targets of Antibody Binding
The use of monoclonal antibodies (mAbs) in research, diagnostics and therapeutics is ubiquitous, particularly because of their ability to simultaneously achieve high affinity and specificity. mAbs binding typically involves interactions between it and 5-8 amino acids in a specific spatial arrangement. These interactions at defined positions is what...
Published: 8/13/2024   |   Inventor(s): Neal Woodbury, Laimonas Kelbauskas, Akanksha Singh, Pritha Bisarad
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Computing & Information Technology, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Pharmaceuticals
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Synbodies - High Throughput Development of Synthetic Antibodies
The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the immunized...
Published: 2/23/2023   |   Inventor(s): Stephen Johnston, Neal Woodbury, John Chaput, Chris Diehnelt, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
Conditioned Surfaces for In Situ Molecular Array Synthesis
Array technologies allow scientists to perform large-scale, quantitative, biological analyses such as biomarker discovery, immunomonitoring, epitope mapping and so on. In situ synthesized arrays have advantages in feature density, and sensitivity, however, quality and reliability rely on the quality and consistency of the synthesized molecules. A critical...
Published: 2/23/2023   |   Inventor(s): Neal Woodbury, Zhan-Gong Zhao
Keywords(s): Affinity Reagent, Immunosignature, MicroArray, Peptide Microarray
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Enhanced Applications of Molecular Libraries
There are many methods to analyze molecular libraries (e.g. peptide libraries, nucleic acid libraries, libraries of polymeric or multipart structures) in terms of their functional properties. Often, these methods relate the covalent structure of the molecules in libraries to their function based on consensus sequence analysis. However, many biological...
Published: 2/23/2023   |   Inventor(s): Neal Woodbury, Alexander Taguchi
Keywords(s): Algorithm Development, Array Techs - Micro, Nano, Gen,Proteomic, Biomarker discovery, MicroArray, Peptide Affinity Reagents, Peptide Microarray
Category(s): Life Science (All LS Techs), Computing & Information Technology, Applied Technologies
Enhanced Applications of Molecular Libraries
There are many methods to analyze molecular libraries (e.g. peptide libraries, nucleic acid libraries, libraries of polymeric or multipart structures) in terms of their functional properties. Often, these methods relate the covalent structure of the molecules in libraries to their function based on consensus sequence analysis. However, many biological...
Published: 2/23/2023   |   Inventor(s): Neal Woodbury
Keywords(s):  
Category(s): Computing & Information Technology, Life Science (All LS Techs), Applied Technologies
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/23/2023   |   Inventor(s): Alexander Green, Matthew Gilliam, Kirstie Swingle, Nicholas Stephanopoulos, Neal Woodbury
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors