Search Results - liqiang+zhang

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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Therapeutic backbone and scaffold modification in the physiological environment
This technology enables precise, water-based chemical modification of proteins at their C-terminus using a single, easily removable reagent, preserving protein structure and function and allowing attachment of diverse functional groups for therapeutic, research, and diagnostic applications. Background: Proteins and polypeptides play a central role...
Published: 1/29/2026   |   Inventor(s): Qiang Zhang
Keywords(s): antibody therapy, GLP-1 secretion, Insulin, protein engineering, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering
Droplet-Based Single-Cell Epigenomic Assay
THE CHALLENGE A major challenge in single-cell DNA methylation profiling lies in the inefficiency and high cost of current methods, which rely on labor-intensive, plate- or tube-based workflows that are difficult to scale. These traditional approaches not only require multiple manual steps and expensive reagents but also suffer from significant DNA...
Published: 10/20/2025   |   Inventor(s): Chang Lu, Qiang Zhang
Keywords(s):  
Category(s): Technology Classifications > Biotechnology, Technology Classifications > Biomedical
Production of Cyclic Macrocycle Library for Rapid High Throughput Evaluations in Aqueous Medium
Produces cyclic peptide libraries quickly, cheaply, and without the need of purification. Background: Cyclic peptides are a class of molecules with important biological activities that could provide substantial medical benefit. Cyclic peptides are often used to develop therapeutic agents and biochemical tools. Unfortunately, the most common method...
Published: 1/29/2026   |   Inventor(s): Qiang Zhang, Huan Chen
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
Quantum device using insulating topological material
Quantum device using insulating topological material Princeton Docket # 24-4093-1 Current quantum electronic devices often rely on conducting materials, which can limit their efficiency and scalability due to energy loss and interference from bulk conducting states. Princeton researchers have made a significant breakthrough in this field by developing...
Published: 2/3/2025   |   Inventor(s): M. Zahid Hasan, Md. Shafayat Hossain, Qi Zhang, Zhiwei Wang, Bing Lv, Yugui Yao
Keywords(s):  
Category(s): Quantum Computing and Electrical Engineering
Recovering Critical Elements from Acid Mine Drainage
THE CHALLENGE The demand for certain elements, such as Manganese (Mn), Cobalt (Co), and Nickel (Ni), has surged in recent years due to the rapid growth of battery production for electric vehicles and utility-scale energy storage. The United States government has deemed Co, Ni, and Mn critical elements, primarily because of the country’s high...
Published: 10/17/2025   |   Inventor(s): Wencai Zhang, Qi Li, Rick Honaker
Keywords(s):  
Category(s): Technology Classifications > Energy, Technology Classifications > Mining and Recycling, Technology Classifications, Technology Classifications > Chemicals/Materials
A Novel Carbohydrate Antibody to GalNac1-3Gal and Its Application for Cancer Diagnostic and Prognosis
Abstract: Cervical cancer is one of the most common cancers among women worldwide. Currently, physical descriptors such as tumor size and depth are the primary factors used for deciding the course of treatment. Despite significant efforts to identify prognostic biochemical markers or therapeutic targets to improve diagnosis and treatment, none have...
Published: 4/22/2025   |   Inventor(s): Jeffrey Gildersleeve, Zhitao Li, Qian Li, Miriam Anver, Donna Butcher
Keywords(s): ANTIBODY, CERVICAL, GaLNAc1-3Gal, Gildersleeve, Immunohistochemical staining, Larynx, Prognostic marker, SKIN, Squamous Cell
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Serpin-based Polypeptide Compositions for Wound Healing
Wound healing, although complex, is a remarkably organized process involving hemostasis, inflammation, new tissue generation and remodeling. However, when wounds cover a large surface area, become infected, or occur in patients with impaired healing capacity, such as diabetics or the elderly, wound healing can be prolonged and result in chronic ulceration...
Published: 2/13/2025   |   Inventor(s): Alexandra Lucas, Liqiang Zhang, Jordan Yaron, Douglas McFadden
Keywords(s):  
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
COMBINATION THERAPIES FOR COVID-19 (SARS-COV-2)
The coronavirus disease 2019 (COVID-19) is caused by a novel RNA enveloped coronavirus, SARS-CoV-2 when the virus enters human airway cells via an ACE2-mediated entry process. This entry pathway is facilitated by the cell surface heparan sulfate proteoglycan (HSPG), which enhances viral attachment to the cell surface. Researchers at NIDDK and NCATS...
Published: 10/28/2024   |   Inventor(s): Qi Zhang, Wei Zheng, Catherine Chen, Yihong Ye
Keywords(s): COVID-19, DB4BXX, ENTRY, HEPARAN, option, Sulfate-dependent, Targeting, therapeutic, viral
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics
A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells
Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...
Published: 10/28/2024   |   Inventor(s): Qi Zhang, Yihong Ye
Keywords(s): Cells, HEPARAN, Label, MAMMALIAN, MEMBRANE, Method, PLASMA, PROTEOGLYCAN, R1XXXX, SULFATE, XCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials
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