Search Results - biological+cell+manipulation

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Single Cell In-Situ Extraction with Intact 3D Morphology from Formalin Fixed Paraffin Embedded (FFPE) Tissues
FFPE is a well-established and widely used method for preservation and histological analysis of tissue samples. DNA/RNA/and Proteins can be extracted from FFPE samples, but generally lack single cell resolution and completely lack 3D spatial resolution. Enabling 3D resolution allows the correlation of morphology to information like gene expression,...
Published: 4/25/2023   |   Inventor(s): David Richardson, Thai Tran, Dmitry Derkach, Colleen Ziegler
Keywords(s): Bioanalysis, Biological Cell Manipulation, Bio-Technology, Cancer, Device, Diagnostics, Gene Expression, Genomics, Proteomics, In situ, Molecular Diagnostics, Single-cell analysis
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Targeted Remodeling of Bacterial Genomes Using CRISPR-Nickases
Targeting DNA manipulation is integral to biotechnology and synthetic biology. Large chromosomal rearrangements and deletions have profound impacts on bacterial physiology, such as improved bioproduct levels, increased strain fitness, or changed tolerance to stress and environmental conditions. However, it requires time-consuming and laborious directed...
Published: 2/23/2023   |   Inventor(s): Xiao Wang, Kylie Standage-Beier
Keywords(s): Biological Cell Manipulation, Bio-Technology
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Injectable Microengineered Tissues for Cardiac Regeneration
Each year, millions of patients, globally, suffer from heart failure and cardiovascular disease. Stem cell transplantation and tissue engineering strategies have tremendous potential for repair and/or regeneration of injured myocardium. The major hurdles in stem cell transplantation are poor cell survival, insufficient cardiogenic differentiation,...
Published: 2/23/2023   |   Inventor(s): Mehdi Nikkhah, Brent Vernon
Keywords(s): Biological Cell Manipulation, Cell Culture, MEMS, Tissue, Tissue Repair
Category(s): Life Science (All LS Techs), Biomaterials, Advanced Materials/Nanotechnology, Non-Cancer Therapeutics
Microorganisms Engineered to Produce Phenol and its Derivatives
The market interest in biosynthesis of important commodity chemicals is steadily growing, driven by sustainability concerns and by increased environmental awareness. However, most production technologies rely on petroleum or food crops as feedstocks. Phenol is one such useful and versatile chemical, which is typically derived from petrochemical feedstocks;...
Published: 2/23/2023   |   Inventor(s): David Nielsen, Shawn Pugh, Brian Thompson
Keywords(s): Biofuels Production, Biological Cell Manipulation, Bioplastic and Biopolymers, Microbes, bacteria, fungi, virus, yeast, Renewable Products and Chemicals
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Life Science (All LS Techs)