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Modular 3D Printed Devices for Sample Delivery
­Background Microfluidic devices are commonly used in serial crystallography applications. In most serial crystallography experiments, the sample molecules are formed into droplets through electrical stimulation, then injected into a focused beam of electrons or X-rays so their structure can be analyzed. The various components of the experiment...
Published: 2/23/2023   |   Inventor(s): Alexandra Ros, John Spence, Diandra Doppler, Garrett Nelson, Richard Kirian, Reza Nazari, Ana Egatz-Gomez, Mukul Sonker, Mohammad Rabbani
Keywords(s):  
Category(s): Physical Science, Bioanalytical Assays, Chemistries & Devices
Two-Photon Laser Lithography for Fabrication of XFEL Sample Injectors
X-ray Free Electron Lasers (XFEL) are a valuable tool for determining the structure of biological macromolecules. Obtaining accurate results necessitates solvation of the sample in a specified chemical solution throughout the injection process. This solvation must not unduly compromise the vacuum environment or cleanliness of the XFEL scattering chamber....
Published: 2/23/2023   |   Inventor(s): R. Bruce Doak, Garrett Nelson
Keywords(s): Bioanalysis, Liquid Handling and Dispensing, Lithography, Micro-Fluidics, Nanostructure, Protein Assays
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Imaging, Physical Science, Physics