Search Results - joshua+labaer

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Antimicrobial Antibody Panels for Lung Cancer Detection
the second most common cancer in both men and women and the leading cause of cancer death in the US. Although there are risk factors for lung cancer, such as smoking, there are many cases where the patient never smoked. Because of this, there is growing interest in investigating the lung microbiota and how that may promote or prevent disease. Yearly...
Published: 8/2/2023   |   Inventor(s): Mahasish Shome, Ji Qiu, Yunro Chung, Joshua LaBaer
Keywords(s):  
Category(s): Cancer, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Autoantibodies for Identification of False Positives of Disease and Uses Thereof
Autoantibodies are an excellent biomarker for both autoimmune disease and cancer, however, some autoantibodies, called common autoantibodies, have been found to occur frequently in healthy individuals. The presence of these common autoantibodies can impede the search for disease-linked autoantibodies or lead to false positives. The identification of...
Published: 3/30/2023   |   Inventor(s): Mahasish Shome, Yunro Chung, Ramani Chavan, Jin Park, Ji Qiu, Joshua LaBaer
Keywords(s):  
Category(s): Applied Technologies, Cancer, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Novel Antibodies for Detecting Gastric Cancer or Gastric Intestinal Metaplasia
Gastric cancer (GC) is a major public health problem in many countries, with more than 1 million new cases, worldwide, in 2020, contributing to almost 800,000 deaths. And new research suggests that GC may be on the rise in the US, particularly among younger adults. Early detection of GC often allows for greater therapeutic options, however, because...
Published: 3/7/2023   |   Inventor(s): Joshua LaBaer, Ji Qiu, Lusheng Song, Yunro Chung
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Type 1 Diabetes Biomarkers
Type 1 Diabetes (T1D) is one of the most common juvenile autoimmune diseases and is characterized by progressive destruction of pancreatic ß-cells. By the time of T1D diagnosis, around 70-90% of pancreatic ß-cells are already dead. T1D patients face many potential health complications and co-morbidities which lead to both personal and societal...
Published: 2/23/2023   |   Inventor(s): Joshua LaBaer, Ji Qiu, Xiaofang Bian, Desmond Schatz, Clive Wasserfall, Mark Atkinson
Keywords(s): Autoantibody, Bioanalysis, biomarker, Detection, Diabetes, Diagnostics, Early Detection, ELISA, Screening
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
ErbB4 Inhibitors and Methods of Use
ErbB4 is a receptor tyrosine kinase member with roles in several key pathways associated with cell proliferation, death and differentiation. ErbB4 overexpression is associated with several types of cancers as well as psychiatric and cardiovascular disorders. Currently there are no drugs available for ErbB4-driven pathologies, or methods of identifying...
Published: 2/23/2023   |   Inventor(s): Fernanda Festa, Joshua LaBaer, Jin Park, Femina Rauf
Keywords(s): Biosignature, Cancer, Diagnostics, Genomics, Proteomics, Protein Kinase Inhibitors
Category(s): Pharmaceuticals, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
Biomarkers for Diagnosis of Lung Cancer
In 2021, 134,592 people died from lung cancer, or 22% of all cancer deaths. Lung cancer is the leading cause of cancer death overall and among both men and women. While the increased use of CT screening for lung cancer has resulted in a reduction in lung cancer mortality, it has also resulted in an increased detection of benign pulmonary nodules. Patients...
Published: 10/29/2024   |   Inventor(s): Joshua LaBaer, Ji Qiu, Jie Wang, Garrick Wallstrom, Jin Park, William Rom, Harvey Pass
Keywords(s): Autoantibody, Biomarker discovery
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Multiplexed Methylated DNA Immunoprecipitation Sequencing (Mx-MeDIP-Seq)
link;color: #0000FF;border-collapse: collapse; } DNA methylation is an epigenetic process that plays a critical role in gene expression modulation and has been implicated in many diseases, particularly cancer. One method to study the variability in methylation patterns is whole-genome bisulfite sequencing (WGBS), which analyzes single base methylation...
Published: 2/23/2023   |   Inventor(s): Joshua LaBaer, Vel Murugan, Inam (Maryam) Ridha
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Biomarkers for the Early Detection of Breast Cancer
Despite recent advances in early detection and treatment, breast cancer remains a common and devastating health problem. With the advent of molecularly-targeted therapeutics, biomarkers that are associated with biological subtypes of cancer may be useful for predicting responses to therapeutic interventions. Researchers at the Biodesign Institute...
Published: 3/24/2023   |   Inventor(s): Joshua LaBaer, Karen Anderson, Garrick Wallstrom, Sahar Sibani, Niroshan Ramachandran
Keywords(s): Diagnostics
Category(s): Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Biomarkers for Early Detection of Serous Ovarian Cancer
Ovarian cancer is one of the most common cancers among women, with over 21,000 new cases and over 14,000 deaths per year. If detected early, the 5-year survival rate is over 80%, but that drops to just 11% if detected at stage IV, and over 60% of patients are diagnosed with advanced disease. Early detection is hampered by limitations in current biomarkers,...
Published: 2/23/2023   |   Inventor(s): Benjamin Katchman, Karen Anderson, Garrick Wallstrom, Joshua LaBaer, Daniel Cramer
Keywords(s): Antibodies, Autoantibody, Biomarker discovery, Cancer, Diagnostics, Early Detection, Immunosignature, Ovarian Cancer
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Novel Biomarkers for Detecting Epstein-Barr Virus-Associated Gastric Cancer
Gastric cancer (GC) is a major health public problem in many countries, with more than 1 million new cases, worldwide, in 2018, contributing to almost 800,000 deaths. And new research suggests that GC may be on the rise in the US, particularly among younger adults. Early detection of GC often allows for greater therapeutic options, however, because...
Published: 2/23/2023   |   Inventor(s): Joshua LaBaer, Ji Qiu, Lusheng Song, Yunro Chung
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Cancer Therapeutics, Diagnostic Assays/Devices, Proteomic Assays/Reagents/Tools, Life Science (All LS Techs), Vaccines/Antimicrobials
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