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Novel Antifungal Agents with Dual Mechanism of Action

With a clear and growing unmet need, a novel mechanism of action, and demonstrated in vitro superiority over current standard-of-care agents, these novel boron-based antifungal agents represent a compelling early-stage opportunity with significant commercial and public health relevance. Background: Invasive fungal infections caused by opportunistic...

Published: 7/24/2026 | Updated: 7/24/2026 | Inventor(s): Bhaskar Das, Joshua Nosanchuk, Daniel Miranda

Keywords(s): Chemistry, Featured, Healthcare, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines

Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines

Novel Small Molecule Agents for Glioblastoma

Brain-penetrant small molecule agents possessing a dual targeting mechanism of action (LonP1 and CT-L proteasome inhibition) that may overcome resistance mechanisms that currently plague standard of care treatments for brain tumors such as glioblastoma. Background: Malignant astrocytomas, including glioblastoma (GBM), represent highly aggressive intracranial...

Published: 7/10/2026 | Updated: 7/6/2026 | Inventor(s): Bhaskar Das, Daniela Bota

Keywords(s): Chemistry, Nanotechnology, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines

Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines

Anti-CD133 Monoclonal Antibodies as Cancer Therapeutics

Abstract: Most early work on CD133 was carried out using one of two monoclonal antibodies (mAbs), AC133 and AC141, which recognize an undefined glycosylated epitope of CD 133. Researchers from NCI's Pharmacodynamic Assay Development and Implementation Section generated novel anti-human CD133 monoclonal antibodies from large extracellular domain loops...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Thomas Pfister, Robert Kinders, Allison Marrero

Keywords(s): Anti-CD133, Biomarker, CANCER, Diagnostic Tool, Immunology, Rabbit Monoclonal Antibodies, screening

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Oncology

Type 1 Diabetes Biomarkers

Type 1 Diabetes (T1D) is one of the most common juvenile autoimmune diseases and is characterized by progressive destruction of pancreatic ß-cells. By the time of T1D diagnosis, around 70-90% of pancreatic ß-cells are already dead. T1D patients face many potential health complications and co-morbidities which lead to both personal and societal...

Published: 2/13/2025 | Updated: 2/1/2023 | Inventor(s): Joshua LaBaer, Ji Qiu, Xiaofang Bian, Desmond Schatz, Clive Wasserfall, Mark Atkinson

Keywords(s): Autoantibody, Bioanalysis, biomarker, Detection, Diabetes, Diagnostics, Early Detection, ELISA, Screening

Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools

Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents

Homocystinuria (HCU), a group of inherited disorders, causes symptoms ranging from failure to thrive and developmental delays in infants or young children to abnormal blood clots with onset in adults.1 Approximately 1 in 200,000 to 335,000 people have HCU globally.2 Various clinical settings use the dried blood spot (DBS) for sample collection methods...

Published: 5/9/2025 | Updated: 12/14/2022 | Inventor(s): Charles Pickens, Konstantinos Petritis

Keywords(s): 4AXXXX, Agents, ASSAYS, Derivatization, Hcy, HOMOCYSTEINE, Maleimides, Multiplexing, Newborn, Primary, screening, SELECTIVE, VDXXXX, VPXXXX, WFXXXX, WHXXXX, WIXXXX, XCXXXX, XHXXXX, YAXXXX, YDXXXX, YFXXXX

Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Dental, Application > Research Materials, ResearchProducts > Research Equipment, Application > Occupational Safety and Health, Application > Diagnostics

Patient-derived induced pluripotent stem cell (iPSC) lines for the study of lysosomal storage diseases (LSDs)

This technology includes the generation and use of human induced pluripotent stem cell (iPSC) lines that can be used to study and screen potential therapeutics for lysosomal storage diseases (LSDs). LSDs are a group of 50 genetic disorders caused by mutations in the genes encoding lysosomal enzymes and proteins. Although various therapeutic approaches...

Published: 10/28/2024 | Updated: 12/6/2022 | Inventor(s): Miao Xu, Yu-Shan Cheng, Manisha Pradhan, Jizhong Zou, Jeanette Beers, Wei Zheng

Keywords(s): Cell, COMPOUND, DERIVED, Disease, iPS, Lines, Lysosomal, Modeling, PATIENT, screening, Storage, VPXXXX, WIXXXX, XHXXXX

Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Research Materials, ResearchProducts > Research Equipment

Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeutics

CDC researchers have characterized epitopes of Bacillus anthracis Lethal Factor (LF), a critical component of the B. anthracis lethal toxin. These epitopes may allow for development of therapeutics for the treatment or prevention of B. anthracis infection. They may also allow screening for B. anthracis LF in a sample and development of a peptide anthrax...

Published: 4/24/2025 | Updated: 12/6/2022 | Inventor(s): Dennis Bagarozzi, Anne Boyer, Conrad Quinn, Jason Goldstein

Keywords(s): Activiating, Activity, Anthracis, Anthrax, AnthraxToxins, Bacillus, Biodefense, biosecurity, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DA5XXX, DAXXXX, DB3XXX, DB5XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, Epitope, factor, INFECTIOUS, Lethal, MONITOR, MONITORING, Neutralize, Neutralizing, Region, REGULATING, SCREEN, screening, SERODIAGNOSIS, SERODIAGNOSTIC, Serologic, SEROLOGICAL, therapeutic, Therapeutic/Diagnostic, THERAPY, toxin, TOXIN-BINDING, Vaccine, VBXXXX, VETERINARY, Via, VJXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YAXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Antibodies, Application > Diagnostics

Antigen Mixtures for Serological Detection of HHV-8 Infection

This invention describes a highly specific and sensitive serological test for human herpesvirus 8 (HHV-8) infection that uses the Luciferase Immunoprecipitation System (LIPS). A mixture of four virus-specific antigens, including K8.1, v-cyclin, ORF65 and LANA, was shown to provide more robust detection of HHV-8 infection than traditional methods due...

Published: 12/31/2024 | Updated: 12/6/2022 | Inventor(s): Joseph Kovacs, Michael Iadarola, Peter Burbelo

Keywords(s): ANTIGEN, DA4XXX, DAXXXX, DDXXXX, DXXXXX, HERPES, HERPESVIRUS-8, HHV-8, Infection, MIXTURES, Patent Category - Biotechnology, screening, SEROLOGICAL

Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease

NAG-1: A Non-Steroidal Anti-Inflammatory Drug Related Gene Which Has Anti-Tumorigenic Properties

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammatory disease, and their anti-inflammatory effects are believed to result from their ability to inhibit the formation of prostaglandins by prostaglandin H synthase (COX). Two forms of prostaglandin H have been identified, COX-1 and COX-2. The former seems to...

Published: 10/28/2024 | Updated: 12/6/2022 | Inventor(s): Richard Diaugustine, Baek Seung, Thomas Eling

Keywords(s): ANTI-INFLAMMATORY, Anti-Tumorigenic, CAXXXX, CBXXXX, CXXXXX, Diagnostics, DRUG, Duke DNA Project, GAXXXX, GBXXXX, Gene, GXXXXX, NAG-1, Non-Steroidal, Patent Category - Biotechnology, PROPERTIES, Protein, RELATED, screening, SECRETED, That, therapeutics

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology

Diagnostic Tool for Objectively Identifying Early-Stage Parkinson's Disease and Dementia

This non-contact device measures speech patterns to provide an immediate, objective diagnosis of a person's neurological state. The technology, particularly useful for identifying Parkinson's disease, can even be used to evaluate patients in remote locations by analyzing data from real-time phone calls or previously recorded conversations. More...

Published: 1/20/2026 | Updated: 9/14/2022 | Inventor(s): James Harnsberger, John Rosenbek, Supraja Anand, Rahul Shrivastav

Keywords(s): diseases, Screening, Speech

Category(s): Technology Classifications > Medical Devices > Others

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