Search Results - screening

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Anti-CD133 Monoclonal Antibodies as Cancer Therapeutics
Abstract: Most early work on CD133 was carried out using one of two monoclonal antibodies (mAbs), AC133 and AC141, which recognize an undefined glycosylated epitope of CD 133. Researchers from NCI's Pharmacodynamic Assay Development and Implementation Section generated novel anti-human CD133 monoclonal antibodies from large extracellular domain loops...
Published: 4/8/2024   |   Inventor(s): Thomas Pfister, Robert Kinders, Allison Marrero
Keywords(s): Anti-CD133, Biomarker, CANCER, Diagnostic Tool, Immunology, Rabbit Monoclonal Antibodies, screening
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Oncology
Type 1 Diabetes Biomarkers
Type 1 Diabetes (T1D) is one of the most common juvenile autoimmune diseases and is characterized by progressive destruction of pancreatic ß-cells. By the time of T1D diagnosis, around 70-90% of pancreatic ß-cells are already dead. T1D patients face many potential health complications and co-morbidities which lead to both personal and societal...
Published: 2/23/2023   |   Inventor(s): Joshua LaBaer, Ji Qiu, Xiaofang Bian, Desmond Schatz, Clive Wasserfall, Mark Atkinson
Keywords(s): Autoantibody, Bioanalysis, biomarker, Detection, Diabetes, Diagnostics, Early Detection, ELISA, Screening
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents
Homocystinuria (HCU), a group of inherited disorders, causes symptoms ranging from failure to thrive and developmental delays in infants or young children to abnormal blood clots with onset in adults.1 Approximately 1 in 200,000 to 335,000 people have HCU globally.2 Various clinical settings use the dried blood spot (DBS) for sample collection methods...
Published: 7/25/2024   |   Inventor(s): Charles Pickens, Konstantinos Petritis
Keywords(s): 4AXXXX, Agents, ASSAYS, Derivatization, Hcy, HOMOCYSTEINE, Maleimides, Multiplexing, Newborn, Primary, screening, SELECTIVE, VDXXXX, VPXXXX, WFXXXX, WHXXXX, WIXXXX, XCXXXX, XHXXXX, YAXXXX, YDXXXX, YFXXXX
Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Dental, Application > Research Materials, ResearchProducts > Research Equipment, Application > Occupational Safety and Health, Application > Diagnostics
Patient-derived induced pluripotent stem cell (iPSC) lines for the study of lysosomal storage diseases (LSDs)
This technology includes the generation and use of human induced pluripotent stem cell (iPSC) lines that can be used to study and screen potential therapeutics for lysosomal storage diseases (LSDs). LSDs are a group of 50 genetic disorders caused by mutations in the genes encoding lysosomal enzymes and proteins. Although various therapeutic approaches...
Published: 7/25/2024   |   Inventor(s): Miao Xu, Yu-Shan Cheng, Manisha Pradhan, Jizhong Zou, Jeanette Beers, Wei Zheng
Keywords(s): Cell, COMPOUND, DERIVED, Disease, iPS, Lines, Lysosomal, Modeling, PATIENT, screening, Storage, VPXXXX, WIXXXX, XHXXXX
Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Research Materials, ResearchProducts > Research Equipment
Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeutics
CDC researchers have characterized epitopes of Bacillus anthracis Lethal Factor (LF), a critical component of the B. anthracis lethal toxin. These epitopes may allow for development of therapeutics for the treatment or prevention of B. anthracis infection. They may also allow screening for B. anthracis LF in a sample and development of a peptide anthrax...
Published: 7/25/2024   |   Inventor(s): Dennis Bagarozzi, Anne Boyer, Conrad Quinn, Jason Goldstein
Keywords(s): Activiating, Activity, Anthracis, Anthrax, AnthraxToxins, Bacillus, Biodefense, biosecurity, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DA5XXX, DAXXXX, DB3XXX, DB5XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, Epitope, factor, INFECTIOUS, Lethal, MONITOR, MONITORING, Neutralize, Neutralizing, Region, REGULATING, SCREEN, screening, SERODIAGNOSIS, SERODIAGNOSTIC, Serologic, SEROLOGICAL, therapeutic, Therapeutic/Diagnostic, THERAPY, toxin, TOXIN-BINDING, Vaccine, VBXXXX, VETERINARY, Via, VJXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YAXXXX, YBXXXX, Zoo, Zoonotic
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Antibodies, Application > Diagnostics
Antigen Mixtures for Serological Detection of HHV-8 Infection
This invention describes a highly specific and sensitive serological test for human herpesvirus 8 (HHV-8) infection that uses the Luciferase Immunoprecipitation System (LIPS). A mixture of four virus-specific antigens, including K8.1, v-cyclin, ORF65 and LANA, was shown to provide more robust detection of HHV-8 infection than traditional methods due...
Published: 7/25/2024   |   Inventor(s): Joseph Kovacs, Michael Iadarola, Peter Burbelo
Keywords(s): ANTIGEN, DA4XXX, DAXXXX, DDXXXX, DXXXXX, HERPES, HERPESVIRUS-8, HHV-8, Infection, MIXTURES, Patent Category - Biotechnology, screening, SEROLOGICAL
Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease
NAG-1: A Non-Steroidal Anti-Inflammatory Drug Related Gene Which Has Anti-Tumorigenic Properties
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammatory disease, and their anti-inflammatory effects are believed to result from their ability to inhibit the formation of prostaglandins by prostaglandin H synthase (COX). Two forms of prostaglandin H have been identified, COX-1 and COX-2. The former seems to...
Published: 7/25/2024   |   Inventor(s): Richard Diaugustine, Baek Seung, Thomas Eling
Keywords(s): ANTI-INFLAMMATORY, Anti-Tumorigenic, CAXXXX, CBXXXX, CXXXXX, Diagnostics, DRUG, Duke DNA Project, GAXXXX, GBXXXX, Gene, GXXXXX, NAG-1, Non-Steroidal, Patent Category - Biotechnology, PROPERTIES, Protein, RELATED, screening, SECRETED, That, therapeutics
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology
Diagnostic Tool for Objectively Identifying Early-Stage Parkinson's Disease and Dementia
This non-contact device measures speech patterns to provide an immediate, objective diagnosis of a person's neurological state. The technology, particularly useful for identifying Parkinson's disease, can even be used to evaluate patients in remote locations by analyzing data from real-time phone calls or previously recorded conversations. More...
Published: 9/14/2022   |   Inventor(s): James Harnsberger, John Rosenbek, Supraja Anand, Rahul Shrivastav
Keywords(s): diseases, Screening, Speech
Category(s): Technology Classifications > Medical Devices > Others
Radio-Frequency (RF) Imaging Sensor for Advanced Security Fingerprint Biometrics and Mobile Health Monitoring
Current portable and wearable devices use fingerprint analysis for secure authentication. The fingerprint pattern systems analyze only the surface morphology of the fingerprint, making it easy for hackers to spoof and bypass authentication. RF signals can collect tissue information beyond the surface of the finger and can provide increased security...
Published: 2/23/2023   |   Inventor(s): Georgios Trichopoulos, Panagiotis Theofanopoulos
Keywords(s): Authentication, Cyber Security, Cyber-Physical System, Engineering, Fingerprint, Graphenes, Health Monitoring, Medical Devices and Imaging, Mobile Biometrics, Real-Time System, Screening, Smart Devices, Transactions Security
Category(s): Chemical/Biological Sensors, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Physical Science, Intelligence & Security
Protein Oxidation as a Metric of Blood Sample Integrity
Human blood plasma and serum (P/S) samples from clinical studies are often archived by biobanks for future research. Biospecimen integrity is crucial for ensuring the validity of clinically oriented research. P/S samples are not intrinsically stable. Inappropriate handling and storage conditions can result in protein oxidation, which can dramatically...
Published: 2/23/2023   |   Inventor(s): Chad Borges, Matthew Schaab, Douglas Rehder, Joshua Jeffs
Keywords(s): Biocollections, Biospecimen integrity, Screening
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
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