Search Results - zhao+zhao

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A Method for Generating Functional Surface Coatings and Modifications via Self-Assembly of Silk Fibroin and Silk Fibroin-Like Macromolecules
RPI ID: 2019-087-401 Innovation Summary: A non-covalent, bottom-up coating method enables the formation of silk fibroin-based layers on chemically inert and geometrically complex surfaces. The process uses kosmotropic agents to facilitate smooth, homogeneous coatings that are tunable in thickness and free of inhomogeneities. These coatings can incorporate...
Published: 3/10/2026   |   Inventor(s): Runye Zha, Tanner Fink
Keywords(s): antifouling coatings, bioinert, Biomaterial, biomedical coatings, Implant, implant surface, protein structure, Self Assembly, silk, spidroin, Surface modification, surface treatment, thin film coatings, universal coating
Category(s): Biotechnology and the Life Sciences
Printing Nanoporous Ultrathin Membranes for Lithium-Sulfur Batteries
RPI ID: 2019-021-401 Innovation Summary: This technology provides a graphene oxide (GO) printed coating for separator membranes in lithium-sulfur (Li–S) batteries. The printed GO layers block polysulfide migration, addressing the ‘shuttle effect’ that reduces Coulombic efficiency and cycle life. Unlike traditional coatings,...
Published: 3/10/2026   |   Inventor(s): Miao Yu, Fanglei Zhou, Feng Zhao, Jinyun Liao
Keywords(s): Li-S battery, Lithium-Sulfur, Membranes, polysulfide blocking, Rechargeable batteries, ultrathin functional coatings
Category(s): Energy, Environment and Smart Systems
Facile Viral Clearance Validation Through the Development of Fluorescent Viral Surrogates
RPI ID: 2022-017-201 Innovation Summary: This system uses engineered fluorescent viral surrogates to validate viral clearance in bioprocessing. These surrogates mimic the properties of live viruses while being safe and traceable. Fluorescence tagging enables real-time monitoring during purification processes. The method reduces reliance on live virus...
Published: 3/10/2026   |   Inventor(s): Runye Zha, Hannah Doss, Todd Przybycien
Keywords(s): fluorescence, Nanoparticle, Viral clearance validation, viral surrogate particle
Category(s): Biotechnology and the Life Sciences
Downregulation of Promoter Strength for Increased Production of Recombinant Biopolymers
RPI ID: 2021-070-401 Innovation Summary: Recombinant E. coli strains and synthetic protein sequence designs are used to produce disordered polypeptides such as spidroins and elastin-like peptides (ELPs). The system leverages genome engineering to suppress basal expression and redirect cellular resources toward target biopolymer synthesis. This approach...
Published: 3/10/2026   |   Inventor(s): Mattheos Koffas, Derek Nelson, Runye Zha, Alexander Connor
Keywords(s): Biomanufacturing, Biomaterials, Recombinant Protein Engineering, Sustainable Materials
Category(s): Biotechnology and the Life Sciences
Upcycling of Plastic Waste to Recombinant Silk Proteins via Pseudomonas sp
RPI ID: 2021-045-401 Innovation Summary: This method uses engineered Pseudomonas bacteria to convert plastic waste into recombinant silk proteins. The system includes metabolic pathways that degrade polyethylene terephthalate (PET) and redirect carbon into silk protein synthesis. It supports circular bioeconomy models and reduces environmental impact....
Published: 3/10/2026   |   Inventor(s): Runye Zha, Mattheos Koffas, Alexander Connor
Keywords(s): Advanced Materials, Biomanufacturing, Metabolic Engineering, polymer upcycling, sustainability
Category(s): Biotechnology and the Life Sciences
Recombinant Production of Silk Proteins via Bacillus Megaterium Secretion (Updated)
RPI ID: 2023-070-301 Innovation Summary: This technology enables the recombinant production of silk proteins using Bacillus megaterium as a secretion host. The system leverages the bacterium’s natural secretion pathways to produce and release silk proteins extracellularly, simplifying downstream purification. The method supports scalable production...
Published: 3/10/2026   |   Inventor(s): Mattheos Koffas, Runye Zha, Alexander Connor
Keywords(s): advanced polymers, Biodegradable materials, Biomaterial, Biomedical material, Biomimetic material, green polymer synthesis, Materials, silk, sustainable
Category(s): Biotechnology and the Life Sciences
Underwater Localization Utilizing Microwave Induced Thermoacoustic Signals
This invention involves using remote microwave sources to generate thermoacoustic pulses coded with precise location and timing information to compute an underwater vehicle’s position. This localization system uses hydrophones to receive and decode embedded information from the signals to compute their position through multilateration. The system...
Published: 2/18/2026   |   Inventor(s): Hao Xin
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Communications & Networking
Dark Eye Harvester
This invention involves using an insulated light-proof chamber that allows the harvesting of eyes or another light-sensitive biomaterial without light exposure, allowing visual rhodopsin to regenerate more efficiently. The chamber has a cylindrical shape and is attached to a chest cooler with handles on top to rotate the walls. The chamber has multiple...
Published: 2/9/2026   |   Inventor(s): A Departmental Work, Michael Brown
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Research Tools
Exploiting Vulnerabilities and Security Threats in Retrieval-Augmented Generative Models: The LIAR Attack Framework
Invention Description Retrieval-Augmented Generative (RAG) models boost generative AI’s accuracy by connecting large language models (LLMs) with the most current, external, knowledge sources. RAG models are widely used in fact-checking, information retrieval, and AI-driven search engines. Despite their utility, adversarial threats can exploit...
Published: 2/26/2026   |   Inventor(s): Zhen Tan, Chengshuai Zhao, Raha Moraffah, Huan Liu
Keywords(s): Artificial Intelligence, Data Mining, Large Language Models, Machine Learning, Natural Language Processing
Category(s): Artificial Intelligence/Machine Learning, Cybersecurity, Computing & Information Technology, Intelligence & Security, Physical Science
DNA Nanotechnology Platform for 3D Nanoscale Manufacturing
Invention Description One of the main challenges in nanoscale manufacturing is achieving precise three-dimensional (3D) positioning and organization of materials. DNA nanotechnology, such as DNA origami, offers a solution to this problem by leveraging the predictable base-pairing properties of DNA to design and construct nanoscale structures with molecular...
Published: 2/26/2026   |   Inventor(s): Petr Sulc, Hao Liu, Thong Diep, Matthew Sample, Michael Matthies, Joshua Evans
Keywords(s):  
Category(s): Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Vectors/Constructs/Plasmids, Biological Nanotechnology
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