Search Results - orthopaedics

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Control of Periprosthetic Joint Infections (Case No. 2021-334)
Summary: UCLA researchers in the Department of Orthopaedic Surgery have developed a non-invasive method to disrupt biofilms on orthopaedic implants and decrease the overall rate of infections. Background: Prosthetic joint infection (PJI) remains a serious complication in hip and knee arthroplasty, with skyrocketing revision rates across all orthopaedic...
Published: 9/23/2024   |   Inventor(s): Fabrizio Billi, Beth Lazazzera
Keywords(s): Biofilm, Cell Growth, electromagnetic, Infection, Nanoparticle, Orthopaedics, Orthopedics and Prosthetics (O & P), Osteo, Prosthetics
Category(s): Medical Devices > Prosthetics, Chemical > Coatings, Adhesives & Inks, Diagnostic Markers > Immunology, Materials > Membranes, Medical Devices > Coatings, Therapeutics > Orthopaedics
2019-252 Spinopelvic Mobility Sensor Guided Hip Arthroplasty Navigation System
SUMMARY:UCLA researchers from the Department of Orthopedic Surgery have developed sensors to assist surgeons in finding the ideal angle for a hip replacement. BACKGROUND:To reduce dislocation rates after hip surgery, understanding the spinopelvic motion (or how much the pelvis moves or “rolls back”) when a patient goes from a standing to...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Orthopaedics, Surgical Tools
Category(s): Medical Devices > Surgical Tools, Therapeutics > Orthopaedics
2017-529 Titanium Implants with Novel Roughness
SUMMARY: UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a novel titanium implant with hierarchical multi-scale roughness to promote bone growth. BACKGROUND: Titanium implants are used as a scaffold to regenerate bone. Degeneration and injury of bone, joints, and jaw are on a rapid increase...
Published: 7/24/2024   |   Inventor(s): Takahiro Ogawa
Keywords(s): Dental, Medical Devices and Materials, Orthopaedics, Stem Cells / Regenerative Medicine
Category(s): Medical Devices, Therapeutics > Dental
2017-723 An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration
An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and MigrationSUMMARYUCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K....
Published: 7/19/2023   |   Inventor(s): Ichiro Nishimura, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov, Kenzo Morinaga
Keywords(s): Animal Imaging, Autoimmune, Diagnostic Markers & Platforms, Drug Delivery, Fluorescence, Life Science Research Tools, Medical Imaging, Orthopaedics
Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Drug Delivery, Therapeutics > Autoimmune, Medical Devices > Medical Imaging > Fluorescence, Therapeutics > Orthopaedics
2009-254 Functionalized Titanium Implants and Related Regenerative Materials
Functionalized Titanium Implants And Related Regenerative MaterialsSUMMARYUCLA researchers in the Department of Dentistry have developed novel titanium surfaces with enhanced bioactivity in implants and tissue regeneration.BACKGROUNDTitanium implants are widely used in the over 500,000 hip and knee reconstruction procedures performed annually in the...
Published: 7/19/2023   |   Inventor(s): Takahiro Ogawa
Keywords(s): Dental, General Device Coatings, Medical Devices and Materials, Orthopaedics
Category(s): Medical Devices, Medical Devices > Coatings, Therapeutics > Orthopaedics, Therapeutics > Dental
A Functional Monoclonal Antibody Against DC-STAMP
Brief Description: Bone is a very dynamic organ as evidenced by the process of bone remodeling which relies on a delicate balance between bone formation and bone resorption and is orchestrated by osteoblasts (OB) and osteoclasts (OC). The coordinated interplay of OB and OC continuously remodels bone through highly regulated molecular and cellular...
Published: 5/7/2024   |   Inventor(s): Kofi Mensah, Yahui Grace Chiu, Christopher Ritchlin, Edward Schwarz
Keywords(s): Antibody, Anti-inflammatory, Inflammation, Orthopaedics, Osteoporosis, Reagent
Category(s): Research Tools
Mouse Model of Osteoarthritis
Applications: Osteoarthritis (OA) is a common degenerative joint disease and currently there is no effective treatment for the diseases. We have generated a conditional activation genetic mouse model that can help to identify new drugs for the prevention and treatment of osteoarthritis. The mouse model can also test the effect and efficacy...
Published: 5/7/2024   |   Inventor(s): Di Chen
Keywords(s): Mouse, Orthopaedics, Osteoporosis
Category(s): Research Tools
Repair and Regeneration of Articular Cartilage, and the Repair and Regeneration of Fibrocartilaginous Tissues
The invention provides methods for the protection, repair and regeneration of articular cartilage, and fibrocartilaginous tissues using recombinant parathyroid hormones, such the FDA approved biologic agent – teriparatide (Forteo®, Eli Lilly).Problem Solved by this TechnologyCurrently, the only treatments for cartilage degeneration and osteoarthritis...
Published: 5/7/2024   |   Inventor(s): Randy Rosier, Michael Zuscik, Erik Sampson, Susan Bukata, J. Edward Puzas, Regis O'keefe, Hani Awad
Keywords(s): Arthritis, Musculoskeletal, Orthopaedics
Category(s): Therapeutic