Search Results - colitis

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Ex-vivo Production of Regulatory B-Cells for Use in Auto-immune Diseases
Abstract: Regulatory B-cells (Breg) play an important role in reducing autoimmunity and reduced levels of these cells are implicated in etiology of several auto-inflammatory diseases. Despite their impact in many diseases, their physiological inducers are unknown.  Given that Bregs are a very rare B-cell, identifying factors that promote their development...
Published: 8/14/2024   |   Inventor(s): Charles Egwuagu, Ren-Wi Wang, Chengrong Yu
Keywords(s): ARTHRITIS, B-CELL, COLITIS, EYE, Multiple sclerosis, sarcoidosis
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology
LRRK2 Inhibitors: Novel Treatment for Intestinal Bowel Disorders
Use of Leucine Rich Repeat Kinase 2 (LRRK2) inhibitors for the treatment of Intestinal Bowel Disorders (IBD) is disclosed. IBD is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. Crohn's disease and ulcerative colitis, two common forms of idiopathic IBD, are chronic, relapsing...
Published: 10/28/2024   |   Inventor(s): Tetsuya Takagawa, Atsushi Kitani, Warren Strober
Keywords(s): COLITIS, Crohn's, Disease, IB3XXX, inhibitor, LRRK2, TREAT, Ulcerative, VPXXXX, WKXXXX, XEXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Cardiology