Search Results - wing+yee+so

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Combating Opioid-Induced Respiratory Depression Using Setmelanotide
The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....
Published: 7/30/2024   |   Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs
­ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
­ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING Researchers at Stanford have developed a new methodology for image processing that allows for high-throughput characterization of organoid phenotypes. Organoids represent a major step forward in in vitro research studies into a myriad of disease states. 3D organoid models possess key advantages...
Published: 9/14/2023   |   Inventor(s): Polly Fordyce, Christina Curtis, Alexandera Sockell, Wing Wong
Keywords(s): CRISPR, High-Throughput, Imaging, Organoid
Category(s): Technology Classifications > Biology
Reducing amount of helper data in silicon physical unclonable functions (PUFs) via lossy compression
Background Silicon physical unclonable functions (PUFs) are widely used in emerging hardware security applications, such as device identification, authentication, and cryptographic key generation. PUFs generate unique randomness by exploiting inherent random process variation during fabrication. Among them, static random-access memory (SRAM) PUFs that...
Published: 12/8/2023   |   Inventor(s): Michael Orshansky, Ye Wang
Keywords(s):  
Category(s): Physical sciences > Semiconductor
Molecular Classification of Primary Mediastinal Large B Cell Lymphoma Using Formalin-Fixed, Paraffin-Embedded Tissue Specimens
Abstract: Primary mediastinal B-cell lymphoma (PMBCL) is an aggressive type of non-Hodgkin lymphoma that mostly occurs in people between the ages of 30-40. It accounts for 5-7% of all aggressive lymphomas. The diagnosis of PMBCL is challenging as the histological features of PMBCL overlap with diffuse large B-cell lymphoma (DLBCL), another most common...
Published: 4/8/2024   |   Inventor(s): Louis Staudt, Lisa Rimsza, David Scott, George Wright, Anja Mottok, Christian Steid, Elaine Jaffe, Randy Gascoyne, Elias Guerri, Elias Guerri, Elias Guerri, Andreas Rosenwald, Kai Fu, Timothy Greiner, Erlend Smeland, Jan Delabie, Rita Braziel, Wing Chan, Joo Song, Dennis Weisenburger, German Ott, James Cook
Keywords(s): assay, Diffuse Large B Cell Lymphoma, DLBCL, FFPE, Formalin-fixed, GENE EXPRESSION, paraffin-embedded biopsies, PMBCL, Primary Mediastinal Large B Cell Lymphoma, Staudt
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics
Clinical Outcome Predictors for Mantle Cell Lymphoma
Abstract: Mantle cell lymphoma (MCL) is a group of aggressive B-cell lymphomas displaying heterogeneous outcomes after treatment.  Some patients have the slowly progressing disease that does not require immediate treatment, while others have a disease that rapidly progresses despite highly aggressive treatment. A number of prognostic tools have been...
Published: 8/14/2024   |   Inventor(s): Louis Staudt, David Scott, George Wright, Andreas Rosenwald, Pau Abrisqueta, Rita Braziel, Elias Guerri, Wing Chan, Joseph Connors, Diego Villa, Kai Fu, Randy Gascoyne, Timothy Greiner, Elaine Jaffe, Graham Slack, James Cook, Jan Delabie, German Ott, Lisa Rimsza, Dennis Weisenburger, Anja Mottok, Pedro Jares
Keywords(s): B-cell lymphomas, Gene expression profile, Mantle cell lymphoma, Prognostic tool
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Oncology
Tristetraprolin (TTP) Plasmid Vectors for Human and Mouse TTP
Tristetraprolin (TTP) is involved in the physiological regulation of the secretion of at least two important cytokines, tumor necrosis factor alpha (TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). TTP exerts its effects by directly binding to the mRNAs encoding these proteins and destabilizing them, resulting in less secretion. Conversely,...
Published: 7/25/2024   |   Inventor(s): Wi Lai, Perry Blackshear
Keywords(s): Human, Listed LPM Wong as of 4/15/2015, Mouse, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Tristetraprolin, TTP, vectors
Category(s): Collaboration Sought > Licensing
TTP as a Regulator of GM-CSF mRNA Deadenylation and Stability
The disclosed invention provides materials and methods to treat granulocytopenia (low white cell count in the blood) which is characterized by a reduced number of granulocytes (relative) or an absence of granulocytes (absolute). This condition is commonly associated with cancer chemotherapy, but is seen less frequently in a number of conditions including...
Published: 7/25/2024   |   Inventor(s): Wi Lai, Perry Blackshear, Ester Carballo
Keywords(s): Aplastic anemia, Deadenylation, Duke DNA Project, GM-CSF, Granulocytopenia, IB6XXX, IBXXXX, IXXXXX, REGULATOR, STABILITY, Systemic lupus erythematosus, TTP, UA1XXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Reproductive Health, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases
Regulation of RNA Stability
This invention relates to the discovery that tristetraprolin (TTP) can promote the poly(A)RNase (PARN) mediated deadenylation of polyadenylated substrates containing AU-rich elements (AREs). As one aspect of the invention, the inventors have developed a cell free system that may be used for the purposes of assessing the effects of the various system...
Published: 4/8/2024   |   Inventor(s): Wi Lai
Keywords(s): GCXXXX, GXXXXX, IDXXXX, IXXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
2021-225 An Innovative Dielectric Elastomer and Multilayer Dielectric Elastomer Actuator with High Electrically Induced Actuation Strains
SUMMARY: UCLA researchers in the Department of Materials Science and Engineering have developed a dielectric elastomer and layering process that can produce actuators capable of high strain and high frequency actuation. BACKGROUND: Dielectric elastomers (DE) can act as deformable capacitors that can generate a mechanical movement in response to an...
Published: 7/19/2023   |   Inventor(s): Qibing Pei, Erin Askounis, Ye Shi
Keywords(s): Actuator, Capacitor, Dielectric, Elastomer, Electroactive Polymers, Flexible Electronics, Functional Materials, Haptic Technology, Haptic Technology Robotic Surgery, Robotics, Sensors, Smartphone
Category(s): Software & Algorithms, Software & Algorithms > Bioinformatics, Life Science Research Tools, Software & Algorithms > Programs
High Efficiency Carbon-Based Micro-LED
Technology Description Researchers at OSU have developed a new micro-LED utilizing carbon quantum dots that have strong excitation in the blue spectrum with tunable emission at high quantum efficiency in the orange and red, independent of excitation wavelength. The micro-LED structure also has negligible leakage of excitation light in the UV or blue...
Published: 6/1/2023   |   Inventor(s): Li-Jing Cheng, Ye Liu
Keywords(s): carbon quantum dots, Light-emitting materials, micro-LED, Nanomaterials
Category(s): Device, Engineering, Materials Science, Nanoscience & Microtechnologies, Physical Science
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