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Search Results - crispr
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Identification of a Factor That Rescues Dysregulated Endocytosis in Cultured Human Hematopoietic Stem Cells (UCLA Case No. 2023-051)
UCLA researchers in the Departments of Molecular, Cell & Developmental Biology have developed a novel method to enhance the function of hematopoietic stem cells (HSCs) to improve the transplantability of ex vivo expanded human HSCs in clinical settings. BACKGROUND: Hematopoietic stem cells (HSCs), present in blood and bone marrow, can form mature...
Published: 10/3/2024
|
Inventor(s):
Hanna Mikkola
,
Julia Aguade Gorgorio
Keywords(s):
bone marrow
,
bone marrow transplants
,
CRISPR
,
endocytosis
,
engraftment
,
environmental sensing
,
hematopoietic stem cells
,
leukemia
,
MLLT3
,
MYCT1
,
transplantability
Category(s):
Therapeutics > Hematology
,
Life Science Research Tools
,
Therapeutics > Stem Cells And Regenerative Medicine
Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)
UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-
CRISPR
mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...
Published: 1/17/2024
|
Inventor(s):
Serendipity Zapanta Rinonos
,
Albert Lai
Keywords(s):
Brain
,
Cancer
,
Cancer stem cells
,
Chemotherapy
,
Combination therapy
,
CRISPR
,
CRISPR
-Cas9
,
Epigenetics
,
GBM
,
Glioma
Category(s):
Therapeutics > Oncology
,
Therapeutics > CNS and Neurology
ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING Researchers at Stanford have developed a new methodology for image processing that allows for high-throughput characterization of organoid phenotypes. Organoids represent a major step forward in in vitro research studies into a myriad of disease states. 3D organoid models possess key advantages...
Published: 9/14/2023
|
Inventor(s):
Polly Fordyce
,
Christina Curtis
,
Alexandera Sockell
,
Wing Wong
Keywords(s):
CRISPR
,
High-Throughput
,
Imaging
,
Organoid
Category(s):
Technology Classifications > Biology
Gene-based Diagnostic Predicts Patient Response to Cancer Immunotherapy
Abstract: Immunotherapy is a promising method of treating cancer that leverages the immune system to promote tumor rejection. However, certain somatic mutations in cancer cells confer resistance to T cell-mediated cytolysis. To improve the effectiveness of immunotherapies for cancer, there exists a need to prospectively identify patients who are most...
Published: 9/27/2024
|
Inventor(s):
Shashankkumar Patel
,
Nicholas Restifo
Keywords(s):
CRISPR
,
diagnostic
,
Gene
,
Immunotherapy
,
T-cell
,
tumor
Category(s):
Application > Diagnostics
,
TherapeuticArea > Oncology
,
Collaboration Sought > Licensing
DsDNA-templated Substrates as Fluorescent Probes for
CRISPR
-Cas12a-based Diagnostics
New design for
CRISPR
-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 9/24/2024
|
Inventor(s):
Mehmet Yigit
,
Christopher Smith
Keywords(s):
agriculture
,
biotechnology
,
Cas12a
,
Cas12a
,
CRISPR
,
CRISPR
,
detection
,
detection
,
DNA
,
DNA
,
fluorescence
,
fluorescence
,
RNA
,
RNA
,
sensor
,
sensor
Category(s):
Technology Classifications > Diagnostics
,
Campus > University at Albany
DsDNA-templated Substrates as Fluorescent Probes for
CRISPR
-Cas12a-based Diagnostics
New design for
CRISPR
-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 9/24/2024
|
Inventor(s):
Mehmet Yigit
,
Christopher Smith
Keywords(s):
agriculture
,
biotechnology
,
Cas12a
,
Cas12a
,
CRISPR
,
CRISPR
,
detection
,
detection
,
DNA
,
DNA
,
fluorescence
,
fluorescence
,
RNA
,
RNA
,
sensor
,
sensor
Category(s):
Technology Classifications > Diagnostics
,
Campus > University at Albany
NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY
NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY Researchers at the Chan Zuckerberg Biohub have developed an improved method to detect target nucleic acid sequences in a biological sample, NANCI™.
CRISPR
-associated protein (Cas) technology is a sequence-specific...
Published: 3/17/2023
|
Inventor(s):
Emily Crawford
,
Amy Lyden
Keywords(s):
Biomolecules
,
Biosensor System
,
CRISPR
,
Diagnosis
,
Nuclease
Category(s):
Technology Classifications > Biology
PHAGE-MEDIATED DELIVERY OF GENES TO GUT MICROBIOME
PHAGE-MEDIATED DELIVERY OF GENES TO GUT MICROBIOME Researchers at UCSF have developed methods to engineer bacteriophage for gene delivery to gut microbiome. There is broad interest in the influence that the gut microbiome has on host health and disease. Mechanistic insights into the role of the human gut microbiome in the predisposition to and...
Published: 3/17/2023
|
Inventor(s):
Kathy Lam
,
Peter Spanogiannopoulos
,
Peter Turnbaugh
Keywords(s):
Bacterial Pathogenesis
,
CRISPR
,
Genome Editing
Category(s):
Technology Classifications > Biology
FLASH-MS: FINDING LOW ABUNDANCE SEQUENCES BY CAS9 HYBRIDIZATION MASS SPECTROMETRY
FLASH-MS: FINDING LOW ABUNDANCE SEQUENCES BY CAS9 HYBRIDIZATION MASS SPECTROMETRY Researchers at the Chan Zuckerberg Biohub have developed FLASH-MS, a method for nucleic acid sequence detection by endonuclease digestion and mass spectrometry. The rapid detection of low abundance targets from clinical specimens is a central challenge in clinical diagnostics....
Published: 3/17/2023
|
Inventor(s):
Emily Crawford
Keywords(s):
Cas9
,
CRISPR
,
Genome Dissection
,
Nuclease
,
RNA Sequencing
Category(s):
Technology Classifications > Biology
2021-056
CRISPR
RIBONUCLEOPROTEIN COMPLEX GENOME EDITING OF HUMAN INNATE IMMUNE CELLS
Researchers in the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed an optimized strategy for non-viral
CRISPR
-Cas9 ribonucleoprotein gene editing of primary innate immune cells. BACKGROUND:CRISPR (clustered, regularly interspaced, short palindromic repeats) genome engineering has become a powerful tool to investigate...
Published: 9/7/2023
|
Inventor(s):
Timothy O'Sullivan
,
Luke Riggan
,
Andrew Hildreth
Keywords(s):
CRISPR
,
Gene Editing Systems
Category(s):
Therapeutics > Gene Therapy And Editing
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