Search Results - wi+lai

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Tristetraprolin (TTP) Plasmid Vectors for Human and Mouse TTP
Tristetraprolin (TTP) is involved in the physiological regulation of the secretion of at least two important cytokines, tumor necrosis factor alpha (TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). TTP exerts its effects by directly binding to the mRNAs encoding these proteins and destabilizing them, resulting in less secretion. Conversely,...
Published: 10/28/2024   |   Inventor(s): Wi Lai, Perry Blackshear
Keywords(s): Human, Listed LPM Wong as of 4/15/2015, Mouse, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Tristetraprolin, TTP, vectors
Category(s): Collaboration Sought > Licensing
TTP as a Regulator of GM-CSF mRNA Deadenylation and Stability
The disclosed invention provides materials and methods to treat granulocytopenia (low white cell count in the blood) which is characterized by a reduced number of granulocytes (relative) or an absence of granulocytes (absolute). This condition is commonly associated with cancer chemotherapy, but is seen less frequently in a number of conditions including...
Published: 10/28/2024   |   Inventor(s): Wi Lai, Perry Blackshear, Ester Carballo
Keywords(s): Aplastic anemia, Deadenylation, Duke DNA Project, GM-CSF, Granulocytopenia, IB6XXX, IBXXXX, IXXXXX, REGULATOR, STABILITY, Systemic lupus erythematosus, TTP, UA1XXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Reproductive Health, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases
Regulation of RNA Stability
This invention relates to the discovery that tristetraprolin (TTP) can promote the poly(A)RNase (PARN) mediated deadenylation of polyadenylated substrates containing AU-rich elements (AREs). As one aspect of the invention, the inventors have developed a cell free system that may be used for the purposes of assessing the effects of the various system...
Published: 4/8/2024   |   Inventor(s): Wi Lai
Keywords(s): GCXXXX, GXXXXX, IDXXXX, IXXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics