Search Results - duke+dna+project

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Recombinant Vaccines Based on Poxvirus Vectors
The technology offered for licensing is foundational in the area of recombinant DNA vaccines. In the last several years, facilitated through a licensing program of the NIH, the technology has been broadly applied in the development and commercialization of several novel human and veterinary vaccines in the areas of infectious disease as well as cancer...
Published: 10/28/2024   |   Inventor(s): Bernard Moss
Keywords(s): B, BBXXXX, BCXXXX, DC5BXX, DC5XXX, DCXXXX, Duke DNA Project, Hepatitis, INFLUENZA, POX VIRUS, rabies, recombinant, vaccines, vaccinia, virus, VLXXXX, VOXXXX, WNXXXX, XKXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Consumer Products, TherapeuticArea > Infectious Disease
Chimeric SHIV Gag Proteins Optimize T-Cell Response Against HIV Gag
HIV Gag has been included in nearly all HIV vaccines entering clinical trials because of its importance in SIV models and its correlation with protection in HIV-infected long-term non-progressors. However, HIV Gag has proven less immunogenic than Env in phase I clinical trial studies. Through sequence comparison, two regions in HIV Gag have been identified...
Published: 10/28/2024   |   Inventor(s): Gary Nabel
Keywords(s): Against, Cell, chimeric, DC5AXX, DC5XXX, DCXXXX, Development, Duke DNA Project, DXXXXX, Filovirus, GAG, HIV, HIV/SIV, Infection, Optimize, PREVENTIVE, primate, proteins, Responses, T, Vaccine, Vaccine-Induced
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease
Retrovirus Packaging Cell Lines Based on Gibbon Ape Leukemia Virus
Gene therapy and gene transfer have recently been recognized as effective therapeutic tools to combat diseases. Accordingly, market demands for vectors and carriers to facilitate such interventions have surged in recent years. Retroviral vectors provide an efficient and safe means of gene transfer to eukaryotic cells. The present invention relates to...
Published: 10/28/2024   |   Inventor(s): Maribeth Eiden
Keywords(s): APE, Based, Cell, Duke DNA Project, GCXXXX, GIBBON, GXXXXX, IDXXXX, IXXXXX, Leukemia, Lines, LT CASE, Packaging, Retrovirus, virus, WIXXXX
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
Swine Hepatitis E Virus Available For Use in Diagnosis, Prevention and Treatment of Hepatitis E
Hepatitis E virus (HEV) is the cause of Hepatitis E, a liver disease that occurs primarily in developing countries due to fecal contaminated drinking water. Outbreaks of HEV infection have caused epidemics in Africa, Central and Southeast Asia and Mexico and cases of the disease have also been reported sporadically in more developed countries. Hepatitis...
Published: 10/28/2024   |   Inventor(s): Suzanne Emerson, Robert Purcell, Xiang-jin Meng
Keywords(s): DC5BXX, DC5XXX, DCXXXX, Duke DNA Project, DXXXXX, e, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, HEV, PCT/US98/14665, Swine, THEREOF, UAXXXX, USES, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Vaccines
AAV5 Vector and Uses Thereof
The invention described and claimed in this patent application provides for novel vectors and viral particles which comprise adeno-associated virus serotype 5 (AAV5). AAV5 is a single-stranded DNA virus of either plus or minus polarity which, like other AAV serotypes (e.g., AAV4, AAV2) requires a helper virus for replication. AAV type 2 has the interesting...
Published: 10/28/2024   |   Inventor(s): Robert Kotin, John (Jay) Chiorini
Keywords(s): AAV, AAV5, control seq, Duke DNA Project, GB2A1X, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, Listed LPM Reichman as of 4/15/2015, Patent Category - Biotechnology, PCT/US99/11958; WO 99/61601 (12/02/99), Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, viral vector
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
TTP as a Regulator of GM-CSF mRNA Deadenylation and Stability
The disclosed invention provides materials and methods to treat granulocytopenia (low white cell count in the blood) which is characterized by a reduced number of granulocytes (relative) or an absence of granulocytes (absolute). This condition is commonly associated with cancer chemotherapy, but is seen less frequently in a number of conditions including...
Published: 10/28/2024   |   Inventor(s): Wi Lai, Perry Blackshear, Ester Carballo
Keywords(s): Aplastic anemia, Deadenylation, Duke DNA Project, GM-CSF, Granulocytopenia, IB6XXX, IBXXXX, IXXXXX, REGULATOR, STABILITY, Systemic lupus erythematosus, TTP, UA1XXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Reproductive Health, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases
Method of Diagnosing Multidrug Resistant Tuberculosis
The invention can be used to develop tests that are much more rapid than conventional tests for determining drug resistance. It relates to the discovery that a putative gene of Mycobacterium tuberculosis (MTb) with no previously identified function is responsible for the ability of the bacteria to activate a class of second line thioamide drugs used...
Published: 10/28/2024   |   Inventor(s): Andrea Debarber, Khisimuzi Mdluli, Clifton Barry
Keywords(s): DA3XXX, DAXXXX, DB3XXX, DBXXXX, DIAGNOSING, Duke DNA Project, DXXXXX, Methods, Multidrug, RESISTANT, TUBERCULOSIS, Tuberculosis (Mycobacterium tuberculosis), UA1XXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
Hybrid Adeno-Retroviral Vector for the Transformation of Cells (E-258-1998)
The invention described and claimed in this patent application provides for novel hybrid vectors which may be used for cell transformation, either in vivo or in vitro. The hybrid vectors have an adenoviral backbone with retroviral long terminal repeats (LTRs). Such vectors are capable of transforming dividing or non-dividing cells and integrate stably...
Published: 10/28/2024   |   Inventor(s): Bruce Baum, Brian O'connell, Changyu Zheng
Keywords(s): Adeno-Retroviral, Chimeric Vector, Duke DNA Project, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, hybrid vector, Vector, viral vector
Category(s): Application > Therapeutics
Production of Adeno-Associated Viruses in Insect Cells
Adeno-associated virus (AAV) is being developed for gene therapy applications. This virus type presents several advantages over alternate vectors for therapeutic gene delivery. AAV is not considered pathogenic and transduces stably dividing and non-dividing cells. AAV also shows good serotype specificity to various cell types for targeted gene delivery. The...
Published: 10/28/2024   |   Inventor(s): Robert Kotin
Keywords(s): AAV, AAV1, AAV2, AAV5, Adeno-associated, CB2AXX, CB2XXX, CBXXXX, Cells, CXXXXX, Duke DNA Project, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, insect, production, virus
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
NAG-1: A Non-Steroidal Anti-Inflammatory Drug Related Gene Which Has Anti-Tumorigenic Properties
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammatory disease, and their anti-inflammatory effects are believed to result from their ability to inhibit the formation of prostaglandins by prostaglandin H synthase (COX). Two forms of prostaglandin H have been identified, COX-1 and COX-2. The former seems to...
Published: 10/28/2024   |   Inventor(s): Richard Diaugustine, Baek Seung, Thomas Eling
Keywords(s): ANTI-INFLAMMATORY, Anti-Tumorigenic, CAXXXX, CBXXXX, CXXXXX, Diagnostics, DRUG, Duke DNA Project, GAXXXX, GBXXXX, Gene, GXXXXX, NAG-1, Non-Steroidal, Patent Category - Biotechnology, PROPERTIES, Protein, RELATED, screening, SECRETED, That, therapeutics
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology
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