Search Results - vsevolod+polotsky

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Combating Opioid-Induced Respiratory Depression Using Setmelanotide
The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....
Published: 7/30/2024   |   Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs
Intranasal leptin to treat opioid-induced respiratory depression (OIRD) in obese patients
­Respiratory depression is the leading cause of morbidity and mortality associated with opioids. Patients with obesity experience pain and need opioids more frequently than normal-weight individuals. Chronic consumption of opioids is associated with addiction, physical dependence, and tolerance. Tolerance leads to requirement of higher doses of...
Published: 9/11/2024   |   Inventor(s): David Mendelowitz, Vsevolod Polotsky, Carla Freire
Keywords(s):  
Category(s): Technology Classifications > Therapeutics