Search Results - nanoparticles

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Gold Nanocluster-Based PROTAC Targeting pTau
​ Gold nanocluster binds both pTau and E3 ligase, initiating the ubiquitin-proteasome pathway and degrading pTau, as seen via immunostaining (Blue – Hoechst, red – TUJ1, green – pTau) Invention Summary: Hyperphosphorylated tau protein, a key clinical marker for various neurodegenerative diseases, leads to abnormal aggregation...
Published: 9/12/2025   |   Inventor(s): Sarah Nevins, Ki-Bum Lee
Keywords(s): Alzheimer’s, Drug Delivery, Inflammation, Nanoparticles
Category(s): Technology Classifications > Biomaterials, Technology Classifications > CNS Disorder, Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering
Telodendrimer Nanoparticles for Protein Delivery
A nanoparticle-based method for enhanced delivery of protein/peptide therapeutics. Background: Biologics, for example protein and peptide-based therapeutics, have poor in vitro shelf stability and in vivo enzymatic stability, which lead to short blood circulating time and contribute to immunogenicity. In addition, biologics are impermeable to biological...
Published: 5/13/2025   |   Inventor(s): Juntao Luo, Xu Wang, Changying Shi, Alexa Bodman, Walter Hall
Keywords(s): cancer therapy, lipidoids, nanoparticles, protein delivery, telodendrimers
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Nanotechnology
Charge Storage Device Architecture for Increased Energy and Power Density (Case No. 2009-392)
Summary: UCLA researchers have developed a novel electrochemical capacitive energy storage device with high energy and power density, addressing limitations in current energy storage technologies and meeting the demands of increasing electrification. Background: Current energy storage devices, such as lithium-ion batteries and electrochemical capacitors,...
Published: 4/28/2025   |   Inventor(s): Bruce Dunn, George Gruner, John Wang, Sarah Tolbert, Torsten Brezesinski
Keywords(s): battery-less, battery-less IoT, Capacitor, Charge Carrier, charge collection efficiency, charge extraction, charge sharing, charge summing, charge-transfer, clean energy, electric vehicle charging, energy conversion, Energy Density, Energy Efficiency, Energy Harvesting, energy management, Energy Management System, Energy positive, energy-efficient, grid energy, Lithium Battery, Lithium-Ion Battery, material characterization, Nanoelectronics, Nanomaterials, Nanoparticles, Nanostructure, nanostructured materials, Nanotechnology, Rechargeable Battery, Rechargeable Battery Thermal Conductivity, Renewable Energy, Renewable energy sources, Solar Energy, supercharger, Surface Charge, Thermal Energy Storage, wireless energy harvesting
Category(s): Materials, Materials > Nanotechnology, Energy & Environment, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Electrical, Electrical > Electronics & Semiconductors
Atomically Smooth Nanoporous Alumina Thin Films
A novel method of producing near-atomically smooth and porous alumina thin films with a tunable index of refraction Background Typically, high quality thin films are produced via vacuum-based techniques, though the nature of this technique makes it difficult to produce porous films. In lieu of vacuum techniques, solution processing is a low-energy...
Published: 8/4/2025   |   Inventor(s): Douglas Keszler, Cory Perkins, Ryan Mansergh, Juan Ramos
Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), anti-reflective coating, Nanofabrication, Nanoparticles, Nanotechnology, solar cell, Solar flux absorption, Solar Thermal, surface chemistry, Thermal Management, Thin layer chromatography
Category(s): Engineering
3D Scaffold for T Cell Delivery and Suppression of Tregs for Solid Tumors (UCLA Case No. 2020-193)
SUMMARY: UCLA researchers in the Department of Bioengineering have developed a small and biodegradable implant that when placed adjacent to solid tumors, enhances immune response to cancer cells. BACKGROUND: The body’s immune system uses proteins called antibodies to train the immune response to foreign pathogens. This mechanism can combat...
Published: 7/31/2025   |   Inventor(s): Manish Butte
Keywords(s): cytokines, Drug Delivery, Immunotherapy, Nanoparticles, scaffolds, solid tumors, T-cell activation, t-cells
Category(s): Platforms > Drug Delivery > Nanoparticles
NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
​ NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription. Invention Summary: As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 8/12/2025   |   Inventor(s): Ki-Bum Lee, Sy-Tsong Chueng, Hyeon-Yeol Cho, Young Sup Yoon
Keywords(s): Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
​ Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 8/12/2025   |   Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Anti-Inflammatory Drug Eluting Patches for Treatment of Ocular Injuries (UCLA Case No. 2022-156)
UCLA researchers in Department of Chemical and Biomolecular Engineering developed a visible light crosslinkable hydrogel-based drug delivery platform that can achieve sustainable release of anti-inflammatory drug molecules to address unmet need of drug bioavailability in ocular injury treatment. BACKGROUND: The Centers for Disease Control and Prevention...
Published: 7/17/2025   |   Inventor(s): Nasim Annabi
Keywords(s): eye disease, gelpatch, hyaluronic acid, micelles, Nanoparticles, ocular, ocular inflammation, Ophthalmic antibiotics, Ophthalmology
Category(s): Therapeutics > Ophthalmology
Method of Treating Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)
UCLA researchers in the School of Engineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC reports that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...
Published: 7/17/2025   |   Inventor(s): Zhen Gu
Keywords(s): glucose intolerance, liver fibrosis, Nanoparticles, Notch signaling pathway, obesity
Category(s): Therapeutics > Metabolism And Endocrinology
Nisin-Based Formulations for Oral and Systemic Conditions (UCLA Case Nos. 2023-133 and 2022-306)
UCLA researchers in the Department of Dentistry have found a novel use for nisin alone, and in formulations, for use in the treatment of Alzheimer’s disease, and multiple inflammation states such as brain inflammation, joint inflammation, oral inflammation, systemic inflammation, inflammatory bowel diseases, and non-alcoholic fatty liver disease...
Published: 7/17/2025   |   Inventor(s): Yvonne Kapila
Keywords(s): Alzheimers disease, Antibacterial, gut inflammation, Inflammation, microbiome, nanoparticle delivery system, Nanoparticles, nisin, oral inflammation, periodontal disease, periodontal inflammation, periodontal regeneration
Category(s): Therapeutics > CNS and Neurology
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