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Search Results - diagnostics
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Anti-LILRB5 Monoclonal Antibodies for Therapeutic and Diagnostic Use
Tumor microenvironment (TME) plays a critical role in regulating immune responses to tumors. UTHealth Houston and UTSW researchers discovered certain membrane tyrosine kinase Eph receptors, including EphA7 and EphB1, specifically bind to the immune inhibitory receptors leukocyte Ig-like receptor family B 5 (LILRB5) and result in bi-directional signaling....
Published: 3/4/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
,
Oncology
Anti-LILRB1 Monoclonal Antibodies for Therapeutic and Diagnostic Use
LILRB1 expression on myeloid cells regulates both innate and adaptive immune responses. Researchers at UTHealth Houston and UTSW developed novel agonistic anti-LILRB1 monoclonal antibodies (mAbs) for autoimmune and inflammatory disease treatments, and novel antagonistic anti-LILRB1 mAbs for cancer immunotherapies. Background LILRB1, a member of the...
Published: 3/4/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
,
Oncology
Anti-LAIR1 Monoclonal Antibodies for Therapeutic and Diagnostic Use
Leukocyte associated immunoglobulin like receptor 1 (LAIR1 or CD305) is an immune inhibitory receptor expressing on most immune cell types. Researchers at UTHealth Houston and UTSW generated novel antagonistic anti-LAIR1 monoclonal antibodies (mAbs) that inhibited the activity of immunosuppressive myeloid cells and reactivated T cells from cancer patients...
Published: 3/4/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
,
Oncology
Anti-LILRB3 Monoclonal Antibodies for Therapeutic and Diagnostic Use
UTHealth Houston and UTSW researchers discovered that LILRB3 stimulates NF-κB signaling and enhances acute myeloid leukemia (AML) cells. They generated a panel of novel anti-LILRB3 monoclonal antibodies (mAbs), which exhibited increasing killing of leukemia cells and promoting cytotoxic T cell activity against tumors. Background Leukocyte immunoglobulin-like...
Published: 3/4/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Oncology
,
Therapeutics
A Novel, Human-Derived HER2 Antibody for Cancer Therapeutics and
Diagnostics
Summary Vanderbilt researchers have discovered a human-derived antibody that recognizes HER2, a protein overexpressed in various cancers. These antibodies offer potential novel cancer therapeutics and diagnostic tools with improved immunological compatibility compared to humanized antibody alternatives. Addressed Need The HER2 protein is overexpressed...
Published: 1/20/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
Malassezia-Secreted Factor with Antibiotic Activity
1. Technology Overview The invention introduces a novel antimicrobial activity produced by human-associated fungi, specifically Malassezia sympodialis, for potential development as antibiotics. The secreted factor exhibits bactericidal activity against Staphylococcus aureus and enhances bacterial sensitivity to other antibiotics, making it suitable...
Published: 1/8/2026
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Inventor(s):
Matthew Barber
,
Caitlin Kowalski
Keywords(s):
Category(s):
Therapeutics
,
Diagnostics
,
Research Tools
Anion Sensing with nanoMOF Electrodes
1. Technology Overview The invention introduces a novel method for selective anion sensing using chromium triazolate metal-organic framework (MOF) nanocrystals. These nanocrystals enable the detection of anion identity and concentration through voltammetric sweeping, offering high selectivity, sensitivity, and reusability. The technology leverages...
Published: 1/7/2026
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Inventor(s):
Carl Brozek
,
Jiawei Huang
Keywords(s):
Category(s):
Chemistry
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Diagnostics
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Materials Science
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Physical Science
,
Nanoscience & Microtechnologies
Non-Linear Single-Molecule FRET
1. Technology Overview The invention introduces a novel method for measuring the relative orientation of donor-acceptor (D-A) pairs in fluorescence resonance energy transfer (FRET) microscopy. This method leverages non-linear spectroscopy and phase-tagged photon counting to achieve precise measurements of the relative orientation and distance between...
Published: 12/31/2025
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Inventor(s):
Andy Marcus
,
Claire Albrecht
Keywords(s):
Category(s):
Imaging
,
Diagnostics
AI-Driven Molecular Skin Analysis & Personalized Skincare
SUMMARY Vanderbilt researchers have developed a novel skin assessment platform that analyzes the molecular composition of skin using mass spectrometry and employs artificial intelligence to match individuals with optimal skincare products. This technology delivers scientifically informed, user-specific insights and product guidance, enabling consumers...
Published: 12/9/2025
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Inventor(s):
Keywords(s):
Category(s):
Computer Science & Communications
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Health Care IT
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Bioinformatics
,
Diagnostics
RNA Biomarkers for Mild Traumatic Brain Injuries
With generous support from Riddell, TGen has developed a noninvasive diagnostic method for mild traumatic brain injury (mTBI) using advanced genomic analyses of circulating DNA and extracellular RNA (exRNA) existing in bodily fluids that can be easily sampled in the field such as blood, urine, and salvia, and bodily fluids that can be further sampled...
Published: 11/3/2025
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Inventor(s):
Kendall Van-Keuren Jensen
,
Matt Huentelman
,
Ashish Yeri
Keywords(s):
Category(s):
Diagnostics
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