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New Therapeutic Strategy for Pancreatic Cancer with Wnt Inhibitors from Phenoxazine Derivatives
This invention is for a novel small molecule therapy for the treatment of Pancreatic ductal adenocarcinoma (PDAC). This new set of compounds contain inhibitors that have shown successfully slowed tumor progression by reducing expression of two major tumor-causing mutated oncoproteins in mouse models.
Background:
Pancreatic ductal adenocarcinoma (PDAC)...
Published: 3/24/2025
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Inventor(s): Daekyu Sun
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Non-Caloric Carbohydrate Supplement Improves Brain Function During Aging
Delivers Monosaccharides to Bolster Protein Glycosylation and Preserve Cognitive Function in Aging Individuals
This supplement supplies carbohydrates to the brain to enhance cognitive function and metabolism in aging individuals. Protein glycosylation, or the linkage of carbohydrates and proteins, is a key chemical reaction in the brain. While a healthy...
Published: 3/21/2025
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Inventor(s): Ramon Sun, Matthew Gentry, Craig Vander Kooi
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Nutraceutical
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A smart Neuron-Targeted Drug Delivery Platform for the treatment of brain diseases
Unmet Need: Treating brain disorders has long been hindered by the impermeability of the blood-brain barrier (BBB). Even if the drugs or nanoparticles cross the impaired BBB following brain injury or neuroinflammation, their uptake in the key cells involved in the brain diseases, especially neurons, specifically at the site of brain injury, remain the...
Published: 3/12/2025
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Inventor(s): Anjali Sharma, Rishi Sharma, Anubhav Dhull, Aqib Dar
Keywords(s):
Category(s): Technologies > Health & Well-being > Chemistry
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Functional Hierarchical Porous Organic Polymers for Water Purification
Advantages:
High absorption capacity
Fast and controllable kinetics
Facile regeneration and recyclability
Stable under a wide range of conditions
High density of chelating sites
Summary:
Water and energy purification are important factors in minimizing the harsh impact of technology on the environment. Coal-powered fuel stations and waste...
Published: 3/4/2025
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Inventor(s): Shengqian Ma, Qi Sun, Briana Aguila
Keywords(s):
Category(s): Technology Classifications > Energy & Environment
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Method for Accurate Phase Measurement of Non-Coherent Signal (Case No. 2024-191)
Summary:
UCLA researchers led by Associate Professor Aydin Babakhani have developed a novel silicon chip component that enables rapid data transmission at high power efficiencies.
Background:
Orbital angular momentum (OAM) has garnered significant attention recently as a novel dimension for electromagnetic signal transmission. Exploiting the inherent...
Published: 2/14/2025
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Inventor(s): Aydin Babakhani, Wei Sun, Sidharth Thomas
Keywords(s):
Category(s): Electrical, Electrical > Electronics & Semiconductors, Electrical > Wireless, Electrical > Signal Processing
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A Three-Buckyball Platform to Synthesize Structurally Defined Water-Soluble Metallofullerene Derivatives
Invention Summary:
Fullerenes, an allotrope of carbon, are polyhedral closed cages. Fullerenes are able to host additional atoms within their inner spheres. Fullerenes hosting electropositive metals (e.g. Sc, Gd, La), known as endohedral metallofullerenes (EMFs), are especially interesting as the encapsulated metals provide additional...
Published: 11/26/2024
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Inventor(s): Jianyuan Zhang, William Kopcha, Yue Sun, Rohin Biswas, Yanbang Li
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Imaging, Technology Classifications > Nanotechnology
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Enhanced VR Battery Life through Perception-Guided Color Encoding
Innovative VR display power reduction using color perception technology, which enhances battery life without sacrificing visual quality
Institute Reference: 1-24019
Background
The rapid advancement of Virtual Reality (VR) and Augmented Reality (AR) technologies has resulted in a growing demand for higher resolution, faster refresh rates, and improved...
Published: 10/22/2024
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Inventor(s): Yuhao Zhu, Abhishek Tyagi, Jiayi He, Budmonde Duinkharjav, Kenneth Chen, Qi Sun, Nisarg Ujjainkar
Keywords(s):
Category(s): Optics, Computer Software, Devices
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Exploiting Human Color Discrimination for Memory- and Energy-Efficient Image Encoding in Virtual Reality
A VR image compression algorithm reducing DRAM traffic by 66.9% with minimal perceptual quality loss
Institute Reference: 1-24027
Background
Virtual Reality (VR) is emerging as a ubiquitous computing platform, with applications spanning healthcare, education, communication, training, and design. Efficient computing substrates are critical to VR’s...
Published: 10/22/2024
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Inventor(s): Yuhao Zhu, Nisarg Ujjainkar, Ethan Shahan, Kenneth Chen, Qi Sun, Budmonde Duinkharjav
Keywords(s):
Category(s): Optics, Computer Software, Devices
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Methods for data multiplexing in neural networks
Methods for data multiplexing in neural networks
Princeton Docket # 22-3898-1
Current neural network architectures, particularly Transformers, face significant challenges due to their GPU-memory intensity, which limits throughput and increases time and energy costs during training and deployment. To address this issue, Princeton University researchers...
Published: 10/21/2024
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Inventor(s): Karthik Narasimhan, Vishvak Murahari, Carlos Jimenez, Runzhe Yang, Kai Li, Ameet Deshpande, Yushan Su
Keywords(s):
Category(s): Computer Science and Information Technology
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Novel cermet composite for nuclear waste immobilization
1.5-inch diameter cermet synthesized using hot uniaxial sintering
Invention Summary:
Nuclear power generates ~10% of electricity globally and ~20% in developed economies. High-level waste, expected to be produced at the back end of advanced reactor fuel cycles, includes metals, oxides, halide salts, and carbon/graphite...
Published: 10/9/2024
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Inventor(s): Ashutosh Goel, John Vienna, John McCloy, S Sundaram, Aditya Kumar, Hans-Conrad zur Loye, Jake Amoroso
Keywords(s):
Category(s): Technology Classifications > Energy & Battery, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
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