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Search Results - s+sundaram
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Cell Wall Protein 6 (Cwp6) as a Vaccine Component Against Clostridioides difficile Infection
Advantages Broader protection: targets bacterial colonization in addition to toxins A (TcdA) and B (TcdB) Applicability across different C. diff strains: Cwp6 is conserved across various C.diff ribotypes and toxinotypes Dual immune response: administration of Cwp6 with alum adjuvant elicits both systemic and IgG and mucosal IgA antibody responses Summary C.difficile...
Published: 8/26/2025
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Inventor(s):
Xingmin Sun
,
Lubem Agbendeh
Keywords(s):
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Infectious Diseases
High-Sensitivity Acoustic Sensing via Free-Space Coupled Microtoroid Resonators
This technology introduces a high-sensitivity acoustic sensing system based on a microtoroid resonator paired with a free-space optical coupling setup. Sound waves in the environment create tiny vibrations that shift the resonator’s frequency, allowing even subtle acoustic signals to be picked up with great precision. Unlike traditional sensor...
Published: 8/11/2025
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Inventor(s):
Tsu-Te Su
,
Sartanee Suebka
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics > Materials & Fabrication
,
Technology Classifications > Imaging & Optics > Sensors and Detection
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Technology Classifications > Imaging & Optics > Sensors and Detection > Remote Sensing
FLR: A Triple-Target Fusion Vaccine Candidate Against Clostridioides difficile
Advantages Multi-Antigen Targeting for Broad Protection: targets three distinct virulence factors (FliC, LP2, RBD2) simultaneously Targeting Hypervirulent Strain Pathogenesis Significant protection from infection and weight loss Reduced fecal toxin and spore levels Summary Clostridioides difficile (C. difficile) is a bacterium that colonizes...
Published: 8/7/2025
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Inventor(s):
Xingmin Sun
Keywords(s):
Infectious Diseases Treatment
,
Vaccines
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Biomedical Engineering
One-Step Controlled Synthesis of Size Tunable Toroidal Gold Particles Using Green Chemistry
This invention is a method to control the size and shape of nanoparticles. It is a one-step synthesis process capable of tuning gold nanoparticles from 350nm to 1.7 microns using a process that has significantly reduced preparation time; it reduces hours for multi-step fabrication to 30-45 minutes. These synthesized toroidal particles exhibit surface...
Published: 6/27/2025
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Inventor(s):
Tsu-Te Su
,
Phuong Diem Nguyen
,
Xuanru Zhang
Keywords(s):
Category(s):
Technology Classifications > Engineering & Physical Sciences > Electronics
,
Technology Classifications > Materials > Nanomaterials
Low-Power Synthesizer-Free Self-Injection Locked Radar (Case No. 2024-190)
Summary: Researchers at UCLA’s Department of Electrical and Computer Engineering have developed a novel synthesizer-free phase imaging radar that generates high-resolution images with low power consumption. Background: Imaging radars are used in various applications, from self-driving cars and aircraft navigation to medical screening. Traditional...
Published: 8/20/2025
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Inventor(s):
Sidharth Thomas
,
Wei Sun
,
Aydin Babakhani
Keywords(s):
Antennas/Wireless
,
Biosensor
,
Continuous-Wave Radar
,
Electrical
,
Frequency conversion
,
High-resolution
,
Image Resolution
,
Imaging
,
low-power device
,
Phase (Waves)
,
Phase-Contrast Imaging
,
Radar
,
Radar / Antennae
,
satellite imaging
,
Signal-To-Noise Ratio
Category(s):
Electrical > Imaging
,
Software & Algorithms > Image Processing
,
Electrical
,
Electrical > Wireless > Antennas
Enhanced Proteomic Profiling of Human Plasma-Derived Extracellular Vesicles through Charge-Based Fractionation to Advance Biomarker Discovery Potential
Method for enhanced isolation & analysis of plasma-derived extracellular vesicles, improved biomarker discovery & disease diagnostics Background: Current methods for isolating and analyzing extracellular vesicles (EVs) from plasma face significant challenges in achieving adequate purification from abundant plasma proteins, limiting their utility...
Published: 6/13/2025
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Inventor(s):
Alexander Ivanov
,
Xianyi Su
Keywords(s):
Category(s):
Technology Classifications > 1. Life Science > Drug Delivery
,
Technology Classifications > 1. Life Science > Chemistry
Methods for localizing and classifying cavitation activities based on eigen-based frequency selection
Enhancing image-guided therapeutic ultrasound: Precise detection & classification of bubble behavior for better treatment efficacy & safety Background: In therapeutic ultrasound applications, accurately detecting and classifying bubble behavior (cavitation) is crucial for optimizing treatment efficacy and safety. Current methods for passive...
Published: 6/13/2025
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Inventor(s):
Tao Sun
,
Nathan Caso
Keywords(s):
Category(s):
Technology Classifications > 1. Life Science > Biotechnology
,
Technology Classifications > 1. Life Science > Theragnostic
,
Technology Classifications > 3. Computer Science > Imaging
Multivalent Immunogens Against Clostridium Difficile
Advantages Effective against new and recurrent C. difficile infection Targets both C. difficile virulent factors TcdA and TcdB Prevents C. difficile colonization Vaccinations with fusion proteins protect animals against infection with an epidemic C. difficile strain Summary Globally, CDI remains an urgent public health problem. In the United...
Published: 6/12/2025
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Inventor(s):
Xingmin Sun
Keywords(s):
Category(s):
Technology Classifications > Medical > Pharmaceuticals
PTH1R PROTAC
Project ID: TECH-2025-20 Background Every 16 mins a man will die of Prostate cancer. Bone metastasis is the predominant cause of morbidity and mortality in prostate cancer, with > 80 % of lethal cases exhibiting skeletal involvement. Parathyroid hormone-related protein (PTHrP), secreted by tumor cells, binds and activates PTH1R on osteoblasts and...
Published: 6/25/2025
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Inventor(s):
Xiaohong Li
,
Shang Su
,
Tim (Qingbin) Cui
,
Jian-Ting Zhang
Keywords(s):
Category(s):
Oncology
Multi-Object Grasping -- Grasping from Surface of Pile
Advantages: High Efficiency in Cluttered Environments Vision-Guided Dexterity with 6D Pose Estimation Confidence-Driven Grasp Optimization Adaptive to Real-World Variability Scalable for Industrial Automation Summary: Robotic grasping in industries like manufacturing, warehousing, and logistics is still a bottleneck when dealing with dense...
Published: 5/28/2025
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Inventor(s):
Tianze Chen
,
Yu Sun
Keywords(s):
Robotics
Category(s):
Technology Classifications > Engineering > Chemical Engineering
,
Technology Classifications > Engineering > Mechanical Engineering
,
Technology Classifications > Engineering > Industrial Engineering
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