Search Results - plasmid

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Reporter Assay for Detection and Quantitation of Replication-Competent Gammaretrovirus
Abstract: Gammaretroviral vectors were the first viral gene-therapy vectors to enter clinical trials and remain in use. One potential hazard associated with the use of such vectors is the presence of replication-competent retroviruses (RCR) in the vector preparations – either as a result of: 1) recombination events between the plasmids used for...
Published: 4/8/2024   |   Inventor(s): Alan Rein, Amanda (Declined Royalty) Aloia
Keywords(s): Cell line, Gammaretrovirus, Gaussia Luciferase, GENE THERAPY, PLASMID, RCR, Rein, Replication-Competent Retrovirus, Vector Preparation
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Immunology
Reporter Plasmid to Identify Cancer Stem Cells
Abstract: Cancer stem cells are a minority population of cells in tumors that initiate and sustain the cancer and which are resistant to therapy; they may cause tumors to recur after curative treatment.  Current therapies generally do not target cancer stem cells. Scientists at the National Cancer Institute Laboratory of Cancer Biology and Genetics...
Published: 5/23/2024   |   Inventor(s): Lalage Wakefield, Binwu Tang
Keywords(s): Lentiviral, Oct4, PLASMID, reporter construct, Sox2
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials
Plasmids Encoding and Producing Anthrax Toxin Proteins
Plasmid pSJ136-EF-A — A plasmid encoding mutant anthrax toxin proteins such as lethal factor (LF) or edema factor (EF). Anthrax toxin and anthrax toxin fusion proteins may be used as therapeutic agents for cancer. Plasmid PSJ115-LFOS — A plasmid expressing anthrax toxin proteins such as lethal factor (LF) or edema factor (EF) which has the original...
Published: 10/28/2024   |   Inventor(s): Pradeep Gupta, Yiu Cheung, Haijing Hu, Mahtab Moayeri, Stephen Leppla
Keywords(s): Anthrax, Improved, Listed LPM Soukas as of 4/15/2015, Methods, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, production, proteins, RM, TOXINS, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Human CC Chemokine Receptor CX3CR1 / CMKBRL1 cDNA
A plasmid encodes human CC chemokine receptor CX3CR1/CMKBRL1 as described in DNA Cell Biol. 1995 Aug;14(8):673-80, and developed in the laboratory of Philip M. Murphy at the National Institute of Allergy and Infectious Diseases.
Published: 10/28/2024   |   Inventor(s): Philip Murphy
Keywords(s): cc, CC-CMKBRL1, cDNA, Chemokine, Human, PLASMID, RECEPTOR, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
CXCR1 - Human IL-8 Receptor cDNA
A plasmid encodes human interleukin-8 (IL-8) receptor CXCR1. IL-8 is a chemo-attractant cytokine that attracts and activates neutrophils in inflammatory regions.
Published: 10/28/2024   |   Inventor(s): Sunil Ahuja, Philip Murphy
Keywords(s): CB3AXX, CC1XXX, cDNA, CXCRI, Hu, Human, IL-8, IL-8A, Listed LPM Ano as of 4/15/2015, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, Subtype, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Application > Research Materials
Human CCR3 cDNA
A plasmid encodes human C-C motif chemokine receptor 3 (CCR3). It may contribute to the accumulation and activation of eosinophil and other inflammatory cells in the allergic airway.
Published: 10/28/2024   |   Inventor(s): Sunil Ahuja, Christophe Combadiere, James Pease, Philip Murphy
Keywords(s): 4, CCR3, CCR3;, cDNA, Cell, DA4AXX, DE4-CCR3, Expressing, Human, Line, Listed LPM Ano as of 4/15/2015, Murine, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, VLXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease
Human CCR2 cDNA
A plasmid encodes human C-C chemokine receptor type 2 (CCR2). CCR2 play important roles in the recruitment of monocytes/macrophages and T cells.
Published: 10/28/2024   |   Inventor(s): Sunil Ahuja, Christophe Combadiere, James Pease, Philip Murphy
Keywords(s): cc, CCR2, cDNA, Cell, Chemokine, Cloning, EOSINOPHIL, Expression, FUNCTIONAL, Human, Including, line., Listed LPM Ano as of 4/15/2015, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Human FPRL1 / FPR2 cDNA
A plasmid encodes human formyl peptide receptor-like 1 (FPRL1/FPR2).
Published: 10/28/2024   |   Inventor(s): Philip Murphy
Keywords(s): cDNA, FPRL1, Human, Listed LPM Ano as of 4/15/2015, NC3XXX, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, VEXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Research Materials
Human fMLP Receptor / FPR cDNA
A plasmid encodes human fMLP receptor. Formyl peptide receptor (FPR, fMLP receptor) is a G protein-coupled receptor and mediates anti-inflammatory reactions in human neutrophils and other tissues.
Published: 10/28/2024   |   Inventor(s): Philip Murphy
Keywords(s): cDNA, FMLP, Human, Listed LPM Ano as of 4/15/2015, NC3XXX, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, VEXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Research Materials
Regulators of G Protein Signalling (RGS) 1,3,4,5 & 13 cDNAs
Plasmids encode regulators of G protein signalling (RGS).
Published: 10/28/2024   |   Inventor(s): Eric Johnson, Kendall Blumer, John Kehrl, Veronica Kang, Kirk Druey
Keywords(s): &, 1, 13, 3, 4, 5, Listed LPM Maddox as of 4/15/2015, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RGS, RM, RXXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
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