Search Results - therapeuticarea+%3e+rare+%2f+neglected+diseases

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A Key Advancement for Human Norovirus Research and Reverse Genetics
The HEK293T/T7 cell line is a novel development in virology research, particularly for studying human noroviruses. This cell line expresses the T7 RNA polymerase, a key enzyme used in reverse genetics systems. Unlike existing technologies, the HEK293T/T7 cell line offers the unique advantage of being able to produce functional T7 RNA polymerase, which...
Published: 12/10/2024   |   Inventor(s): Carlos Sandoval-Jaime, Stanislav Sosnovtsev
Keywords(s):  
Category(s): Application > Therapeutics, Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases
TYROSINASE Gene Therapy for Oculocutaneous Albinism type 1A
Summary: The National Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral gene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...
Published: 12/23/2024   |   Inventor(s): Brian Brooks, Aman George
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Ophthalmology, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
Alpha-galactosidase-A Knockout Mouse Model for Studying Fabry Disease
This technology includes an alpha-galactosidase-A knockout mouse model that can be used to study Fabry disease, an X-linked lysosomal storage disorder. Alpha-galactosidase-A is a crucial enzyme responsible for the breakdown of glycolipids, particularly globotriaosylceramide (Gb3), within lysosomes. In Fabry disease, a rare and inherited lysosomal storage...
Published: 4/8/2024   |   Inventor(s): Toshio Ohshima, Ashok Kulkarni, Roscoe Brady, Gary Murray
Keywords(s):  
Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Materials Available, ResearchProducts > Animal Models, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Metabolic Disease
Chlamydial Vaccine Technologies
The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia...
Published: 10/28/2024   |   Inventor(s): Laszlo Kari, Deborah Crane, Harlan Caldwell
Keywords(s): Against, Attenuated, -Attenuated, Bacterial strains, Blinding, Chlamydia, DA3XXX, DC4XXX, DCXXXX, DD1XXX, DDXXXX, DISEASES, Human, Immunogenic, Listed LPM Stansberry as of 4/15/2015, Live, Model, MULTIPLE, NON, Patent Category - Biotechnology, Plasmid-deficient, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, primate, Protective, RM, SAFE, Sexually, Strain, Trachoma, TRACHOMATIS, Transmitted, UBXXXX, Vaccine, VJXXXX, WIXXXX, WNXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
T24 Antigen for Diagnosing or Treating Taenia solium Cysticercosis
In order to develop a simple detection assay for field use, CDC researchers cloned and sequenced the Taenia solium T24 diagnostic protein. The T24 sequences can be used to detect and diagnose T. solium infection or can be formulated into a pharmaceutical composition. T. solium is a species of tapeworm. Intestinal infection with T. solium is referred...
Published: 10/28/2024   |   Inventor(s): Fatima Williams, Melinda Yushak, Sowmya Pattabhi, Victor Tsang, Kathy Hancock
Keywords(s): AFXXXX, ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, Cysticercosis, DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, Immunodiagnosis, SOLIUM, T24, TAENIA, UBXXXX, UXXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis
CDC researchers developed a simple target-specific isothermal nucleic acid amplification technique, termed Genome Exponential Amplification Reaction (GEAR). The method employs a set of four primers (two inner and two outer). The outer primer pair targets three specific nucleic acid sequences at a constant 60°C, while the inner pair of primers accelerates...
Published: 10/28/2024   |   Inventor(s): Prithiviraj Jothikumar, Vincent Hill, Jothikumar Narayanan
Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, Acids, ACXXXX, amplification, AMPLIFYING, AXXXXX, DA1XXX, DA2XXX, DA3XXX, DA4XXX, DA5XXX, DAXXXX, DXXXXX, Exponential, Gear, Genome, Isothermal, Methods, Nucleic, REACTION, REAGENTS, UBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Diagnostics
CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Viruses
Mosquitoes are responsible for spreading many viruses that can make people sick, including dengue, Zika, chikungunya, yellow fever, and more. The Centers for Disease Control and Prevention's (CDC's) new autocidal gravid ovitrap (AGO) mosquito trap is an inexpensive, simple-to-assemble, and easy-to-maintain trap that targets female mosquitoes looking...
Published: 10/28/2024   |   Inventor(s): Manuel Amador, Andrew Mackay
Keywords(s): Aedes, Aegypti, AFXXXX, AUTOCIDAL, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CONTROL, DENGUE, DENGUE FEVER, DEXXXX, DXXXXX, GRAVID, insect, Insecticides, Insects, Listed LPM Houze as of 4/15/2015, Malaria, MALARIAL, Mosquito, Mosquitoes, MXXXXX, NON-TOXIC, OID-NCEZID-DVBD, OVITRAP, Pest, PESTICIDE, PESTICIDES, Pests, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Surveillance, Targeting, Tool, TRAP, TRAPPING, UB1XXX, Vector, Vector-based, Vector-borne, Vector-borne diseases, VLXXXX, VOXXXX, VQXXXX, WDXXXX, WEST NILE, WEST NILE VIRUS, WFXXXX, XDXXXX, YFXXXX, Zika, Zoonotic
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Medical Devices, Application > Non-Medical Devices, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Occupational Safety and Health, Application > Therapeutics
Human and Veterinary Cancer Therapeutic Agent Utilizing Anthrax Toxin-Based Technology
Due to the disorganized nature of blood vessels that run through tumors, chemotherapeutic agents often fail to penetrate tumors and kill cancer cells at the tumor’s center. This can lead to ineffective chemotherapeutic treatments, because tumors can quickly grow back if the entire tumor is not destroyed. NIH researchers have developed a therapeutic...
Published: 10/28/2024   |   Inventor(s): Stephen Leppla, Shihui Liu, Thomas Bugge, Diane Peters, Jie Liu, Alexander Wein, Kuang-Hua Chen, Christopher Bachran, Damilola Phillips, Henning Hansen, Sarah Arnett, Clinton Leysath
Keywords(s): Against, AMOUNTS, Anthrax, AnthraxToxins, ANTIGEN, B, CA1BXX, CB1AXX, CB1BXX, CB1XXX, CB3CXX, CBXXXX, Cells, Cell-Surface, CMG2, COMPLEMENTARY, CONTAIN, Containing, CXXXXX, Cytolethal, Distending, EFFICACY, Efficient, ENGINEERED, exclusively, Exploiting, FELINE, FELINE Leukemia, FORM, Fusion, fusion proteins, Having, High, IC2-PA, Identifying, Improved, Leppla, Listed LPM McCue as of 4/15/2015, MARKER, Metallo..., MULTIMERIC, Mutated, Nature, Octamers, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protective, Protein, proteins, SOLID, SPECIFICALLY, Specificity, Strong, TARGET, Targeting, That, THERAPY, toxin, TOXINS, tumor, Types, UAXXXX, VARIANTS, VASCULATURE, VETERINARY
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases
Small-Molecule Inhibitors of Human Galactokinase for the Treatment of Galactosemia and Cancers
Lactose, found in dairy products and other foods, is comprised of two simple sugars, glucose and galactose. In galactosemia, where galactose is not properly metabolized, build-up of toxic compounds, such as galactose-1-phosphate, can lead to liver disease, renal failure, cataracts, brain damage, and even death if this disorder is left untreated. Currently,...
Published: 10/28/2024   |   Inventor(s): Matthew Boxer
Keywords(s): AKT, CANCER, CB7XXX, CBXXXX, CXXXXX, Galactokinase, Galactose, Galactosemia, IBXXXX, Inhibitors, IXXXXX, lactose, Metabolism, PTEN, rare disease, small molecule, UAXXXX
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials
Multivalent Vaccines for Rabies Virus and Filoviruses
No vaccine candidates against Ebola virus (EBOV) or Marburg virus (MARV) are nearing licensure and the need to develop a safe and efficacious vaccine against filoviruses continues. Whereas several preclinical vaccine candidates against EBOV or MARV exist, their further development is a major challenge based on safety concerns, pre-existing vector immunity,...
Published: 10/28/2024   |   Inventor(s): Jason Paragas, Reed Johnson, Peter Jahrling, Joseph Blaney
Keywords(s): Against, Bivalent, Confer, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DDXXXX, Dual, DXXXXX, Ebola, Ebola virus disease, INACTIVATED, Live-Attenuated, Marburg hemorrhagic fever, Protection, rabies, That, UAXXXX, vaccines, Viruses
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases
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