Search Results - therapeuticarea+%3e+rare+%2f+neglected+diseases

45 Results Sort By:
A Key Advancement for Human Norovirus Research and Reverse Genetics
The HEK293T/T7 cell line is a novel development in virology research, particularly for studying human noroviruses. This cell line expresses the T7 RNA polymerase, a key enzyme used in reverse genetics systems. Unlike existing technologies, the HEK293T/T7 cell line offers the unique advantage of being able to produce functional T7 RNA polymerase, which...
Published: 12/10/2024   |   Inventor(s): Carlos Sandoval-Jaime, Stanislav Sosnovtsev
Keywords(s):  
Category(s): Application > Therapeutics, Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases
Novel Kinase Inhibitory Thiazines
Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...
Published: 12/20/2024   |   Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
Reverse Thiazine Kinase Inhibitors
Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...
Published: 12/19/2024   |   Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Collaboration Sought > Licensing
Novel Kinase Inhibitory Aplithianines
Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...
Published: 12/20/2024   |   Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li
Keywords(s):  
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
TYROSINASE Gene Therapy for Oculocutaneous Albinism type 1A
Summary: The National Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral gene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...
Published: 12/23/2024   |   Inventor(s): Brian Brooks, Aman George
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Ophthalmology, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
Alpha-galactosidase-A Knockout Mouse Model for Studying Fabry Disease
This technology includes an alpha-galactosidase-A knockout mouse model that can be used to study Fabry disease, an X-linked lysosomal storage disorder. Alpha-galactosidase-A is a crucial enzyme responsible for the breakdown of glycolipids, particularly globotriaosylceramide (Gb3), within lysosomes. In Fabry disease, a rare and inherited lysosomal storage...
Published: 4/8/2024   |   Inventor(s): Toshio Ohshima, Ashok Kulkarni, Roscoe Brady, Gary Murray
Keywords(s):  
Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Materials Available, ResearchProducts > Animal Models, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Metabolic Disease
Chlamydial Vaccine Technologies
The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia...
Published: 10/28/2024   |   Inventor(s): Laszlo Kari, Deborah Crane, Harlan Caldwell
Keywords(s): Against, Attenuated, -Attenuated, Bacterial strains, Blinding, Chlamydia, DA3XXX, DC4XXX, DCXXXX, DD1XXX, DDXXXX, DISEASES, Human, Immunogenic, Listed LPM Stansberry as of 4/15/2015, Live, Model, MULTIPLE, NON, Patent Category - Biotechnology, Plasmid-deficient, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, primate, Protective, RM, SAFE, Sexually, Strain, Trachoma, TRACHOMATIS, Transmitted, UBXXXX, Vaccine, VJXXXX, WIXXXX, WNXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccines
CDC researchers have developed a potent immunogenic enhancer polypeptide useful for improving flavivirus vaccines. Flaviviruses such as dengue virus (1, 2, 3 and 4), Japanese encephalitis virus, Murray Valley encephalitis virus, St. Louis encephalitis virus, yellow fever virus and tick-borne encephalitis virus are a great burden on public health. ...
Published: 10/28/2024   |   Inventor(s): Holly Hughes, Gwong-Jen Chang
Keywords(s): ADJUSTMENT, adjuvant, Adjuvant-like, BCXXXX, Boost, BOOSTING, CD4, CDC Docket Import, CDC Docket Import CDC Prosecuting, Cell, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DENGUE, DENGUE FEVER, Dengue Vaccine, Dengue-1, Dengue-2, Dengue-Like, DXXXXX, Epitope, Flavivirus, FLAVIVIRUSES, Identification, in vivo, JAPANESE ENCEPHALITIS VIRUS, Listed LPM Houze as of 4/15/2015, Mosquito, Mosquitoes, Nile, OID-NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRIMER, T, THEREOF, Tick-Bone, TICK-BORNE, UBXXXX, Vaccine, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, Vector-borne, Vector-borne diseases, virus, VLXXXX, VOXXXX, WAXXXX, West, WIXXXX, WJXXXX, WMXXXX, XCXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines, Application > Therapeutics, Application > Research Materials, Application > Consumer Products, TherapeuticArea > Infectious Disease
Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pests
In nature, some beetle larvae possess specialized barbed hastate setae that serve as an entanglement defense mechanism and incapacitate other insects. CDC researchers have developed synthetic setae for control and entrapment of insects and other pests. While smaller synthetic setae can trap mosquitoes and small insects, larger “macro” setae can be...
Published: 10/28/2024   |   Inventor(s): Robert Wirtz
Keywords(s): AE2BXX, AE2XXX, AEXXXX, AFXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, CONTROL, DB2XXX, DB4XXX, DBXXXX, DEVICE, Devices, DEXXXX, DXXXXX, Entangling, Entrapment, insect, Insects, Mosquito, Mosquitoes, Net, Pest, Pests, population sampling, PXXXXX, Setae, TRAP, UBXXXX, UXXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WCXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, YFXXXX, Zoo
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Occupational Safety and Health, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease
T24 Antigen for Diagnosing or Treating Taenia solium Cysticercosis
In order to develop a simple detection assay for field use, CDC researchers cloned and sequenced the Taenia solium T24 diagnostic protein. The T24 sequences can be used to detect and diagnose T. solium infection or can be formulated into a pharmaceutical composition. T. solium is a species of tapeworm. Intestinal infection with T. solium is referred...
Published: 10/28/2024   |   Inventor(s): Fatima Williams, Melinda Yushak, Sowmya Pattabhi, Victor Tsang, Kathy Hancock
Keywords(s): AFXXXX, ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, Cysticercosis, DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, Immunodiagnosis, SOLIUM, T24, TAENIA, UBXXXX, UXXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
1 2 3 4 5