Search Results - strain

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Floxed Targeted Mouse Strain for Use in Conditional Deletion of the Irf8 Gene
IRF8, a member of interferon regulatory factor (IRF) family of transcription factors is a novel intrinsic transcriptional inhibitor of TH17-cell differentiation. TH17-cells are believed to be involved in the pathogenesis of various autoimmune/inflammatory diseases. These materials could be used to help define patterns of gene expression important for...
Published: 10/28/2024   |   Inventor(s): Herbert Morse
Keywords(s): Approved, Conditional, Deletion, Design, Development, Gene, Generate, IRF8, Knockout, Listed LPM Vepa as of 4/15/2015, Mouse, Need, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECOGNIZED, RXXXXX, Strain, Used
Category(s): Collaboration Sought > Collaboration, Application > Research Materials
Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population
Rotaviral infection is the most common gastrointestinal illness of children in the world, affecting both developed and developing economies. There is no specific drug treatment for rotavirus infection. Vaccination and good hygiene are key to prevention. Approximately 5-10% of the world's population are Lewis histoblood group antigen negative, that percentage...
Published: 10/28/2024   |   Inventor(s): Yuhuan Wang, Baoming Jiang
Keywords(s): Candidate, CHARACTERIZATION, G9P[6], Human, Isolation, NCIRD, NCIRD-DVD, rotavirus, Strain, Vaccine, VLXXXX, WBXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WNXXXX, XKXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health
Chlamydial Vaccine Technologies
The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia...
Published: 10/28/2024   |   Inventor(s): Laszlo Kari, Deborah Crane, Harlan Caldwell
Keywords(s): Against, Attenuated, -Attenuated, Bacterial strains, Blinding, Chlamydia, DA3XXX, DC4XXX, DCXXXX, DD1XXX, DDXXXX, DISEASES, Human, Immunogenic, Listed LPM Stansberry as of 4/15/2015, Live, Model, MULTIPLE, NON, Patent Category - Biotechnology, Plasmid-deficient, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, primate, Protective, RM, SAFE, Sexually, Strain, Trachoma, TRACHOMATIS, Transmitted, UBXXXX, Vaccine, VJXXXX, WIXXXX, WNXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection
This invention relates to rotavirus vaccine compositions and methods of vaccination. Rotaviral infection is the most commonly occurring gastrointestinal illness of children world, affecting both developed and developing economies. Additionally, rotavirus infections can affect livestock (especially calves and piglets), and resulting mortality/morbidity...
Published: 10/28/2024   |   Inventor(s): Roger Glass, Yuhuan Wang, Jon Gentsch, Baoming Jiang
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CHILDHOOD, Children, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPED, DEVELOPING, DIARRHEA, DXXXXX, Dysentery, GASTRIC, gastrointestinal, Human, Livestock, NEONATAL, Neonates, OID-NCIRD-DVD, rotavirus, Strain, STRAINS, Vaccine, VETERINARY, VETERINARY vaccine, viral, virus, VLXXXX, VOXXXX, WIXXXX, WJXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX, Zoo, Zoonotic
Category(s): Collaboration Sought > Licensing, Application > Research Materials, ResearchProducts > Research Equipment, Application > Vaccines, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease
Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility
HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Researchers discovered that HSPA2 protein is expressed in spermatogenesis during the meiotic phase. Spermatogenic cells lacking the HSPA2 protein arrest in mid-meiosis and undergo apoptosis. HSPA2 is present in the synaptonemal complex of wild-type mice...
Published: 10/28/2024   |   Inventor(s): Edward Eddy
Keywords(s): Deletion, Gene, Generation, Hsp70-2, Hspa2, IDXXXX, IXXXXX, KNOWN, Mouse, previously, Spermatogenesis, Strain, Targeted
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials
New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological, Fibrotic or Cardiovascular Indications
SMAD7 conditional knockout mice are available for licensing. SMAD7 can be knocked out by breeding with CRE-recombinase transgenic mice with a variety of promoters to yield tissue or cell type-specific deletions of SMAD7. SMAD7 has been shown to play a role in bone morphogenesis, cardiovascular tissue generation, immune regulation and fibrosis. Therefore,...
Published: 10/28/2024   |   Inventor(s): Marilyn Diaz
Keywords(s): BAXXXX, Chromosome 7, monosomy, Conditional, Deletion, Deletion 7, Gene., Mouse, RXXXXX, Scleroderma, Scleroderma, systemic, SMAD7, Strain
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, ResearchProducts > Animal Models
T-Cell-Specific Gfi-1 Knockout Mouse
This is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells....
Published: 10/28/2024   |   Inventor(s): William Paul (Estate Of), Jinfang (Jeff) Zhu
Keywords(s): BAXXXX, Cells, FUNCTION, Gfi-1, Gfi1[fl/fl]-CD4Cre, IMPORTANT, KO, Mouse, Regulatory, REVEALS, RXXXXX, Specific, Strain, T, T-cell
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, ResearchProducts > Animal Models
Attenuated Human Parainfluenza Virus (PIV) for Use as Live, Attenuated Vaccines and as Vector Vaccines
The identified technologies describe self-replicating infectious recombinant paramyxoviruses with one or more attenuating mutations, such as a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein, or at least one temperature sensitive mutation and one non-temperature sensitive mutation....
Published: 10/28/2024   |   Inventor(s): Peter Collins, Sheila Nolan, Mario Skiadopoulos, Brian Murphy
Keywords(s): cDNA, CIS-ACTING, Complete, DC5BXX, DC5XXX, DCXXXX, Determination, DXXXXX, FOR..., FRAMES, Gene, Generate, Generation, Genomic, HPIV2, HPIV2., HPIV2/V94, Identification, MEASLES, Mumps, MUTATION, Novel, Nucleotide, Overlapping, P/V, Parainfluenza virus type 3, Parainfluenza virus type 3; Human parainfluenza virus type 3, Reading, recombinant, rHPIV2, Separated, sequence, Strain, UA1XXX, USEFUL, V94
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines, TherapeuticArea > Infectious Disease
Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins
The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each...
Published: 4/8/2024   |   Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot
Keywords(s): Active, Biological, cDNA, CLONE, CONSENSUS, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENCODES, FULL-LENGTH, Genome, Human, MD145-12, Norovirus, proteins, Respresenting, RNA, sequence, Strain, That
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials
Mouse Strain CAR-KO C3H/HeNCrl, Deletion of Nuclear Xenobiotic Receptor CAR
CAR (nuclear constitutive active receptor) is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. It is primarily responsible for sensing foreign toxic substances and in response up regulating the expression of proteins involved in the detoxification and clearance of these substances from the...
Published: 10/28/2024   |   Inventor(s): Masahiko Negishi
Keywords(s): ACXXXX, C3H/HeNCrl, CAR, CAR-KO, Deletion, Listed LPM Contreras as of 4/15/2015, Mouse, nuclear, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, Strain, WIXXXX, Xenobiotic
Category(s): Collaboration Sought > Licensing, Application > Research Materials
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