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Quinoline-derived SARS-CoV-2 papain-like protease inhi
b
itors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhi
b
itor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
B
in Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Specific inhi
b
itors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Preliminary data shows that the inhi
b
itor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yingxian Pan
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications
,
Technology Classifications > Therapeutics
Method for Optimizing an Integrated Flight Control System using Reinforcement Meta-Learning
This technology is a method to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will
b
enefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control...
Published: 7/30/2025
|
Inventor(s):
Ro
b
erto Furfaro
,
B
rian Gaudet
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology
,
Technology Classifications > Engineering & Physical Sciences > Aerospace Engineering
TRP: A Mouse Model of Lim
b
Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
UCLA researchers in the Department of Neurology have developed a novel mouse model for lim
b
girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
|
Inventor(s):
Melissa Spencer
Keywords(s):
Category(s):
Life Science Research Tools > Animal Models
Regioselective 1,2-Dearomatization of Functionalized Azines
b
y Organolanthanide Catalysts
NU2014-129 INVENTORS To
b
in Marks* Alexander Dudnik Massimiliano Delferro Victoria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Catalyst
,
Chemicals
,
Manufacturing/Processing
,
Materials
Category(s):
Physical Sciences > Materials and Industrial Processes
Novel self-healing commodity copolymers
b
ased on 2-ethylhexyl acrylate
NU2023-240 INVENTORS John Torkelson* Tong Wang SHORT DESCRIPTION This invention descri
b
es a new class of random copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Materials
,
Polymer
,
Smart/Functional materials
Category(s):
Physical Sciences > Materials and Industrial Processes
Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of
B
ioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025
|
Inventor(s):
Dino Di Carlo
,
Alyssa Arnheim
,
Michael Mellody
,
Yuta Nakagawa
,
Lily Shang
Keywords(s):
Assay
,
B
Cell
,
b
arcode
,
B
ioassay
,
b
iological assays
,
B
iomarker
,
b
iomarkers
,
B
iomaterial
,
capping particles
,
CAR-T cell platform
,
CAR-T cell therapy
,
cavities
,
cavity-containing particles
,
Cell and tissue culture
,
cell encapsulation
,
cell engineering
,
cell imaging
,
cell mapping
,
cell sorting
,
cell type identification
,
cell-
b
ased therapy
,
centrifugation
,
confinement
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Digital Microfluidics
,
Drug
,
Drug Delivery
,
Drug Discovery
,
drug screening
,
high throughput
,
high throughput assays
,
high throughput testing
,
high-throughput analysis
,
High-Throughput Screening
,
Immunoassay
,
Immunoassay Sense (Molecular
B
iology)
,
Microfluidics
,
Microfluidics And Mem's
,
Microfluidics Nanosphere
,
microparticles
,
moieties
,
Nanoparticle
,
single cell analysis
,
single cell analysis and testing
,
Single cell data
,
single-cell resolution
,
single-cell trapping
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Cell Counting And Imaging
,
Life Science Research Tools > La
b
Equipment
,
Life Science Research Tools > Microscopy And Imaging
,
Life Science Research Tools > Microfluidics And Mems
,
Medical Devices
,
Platforms
Covalent Adapta
b
le Networks with Associative Siloxane Exchange Enabled by Amide-Based Internal Catalysis
NU2025-056 INVENTORS John Torkelson* Tapas De
b
sharma Nathan Purwanto Tong Wang SHORT DESCRIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences > Materials and Industrial Processes
Recycla
b
le and Depolymerizable Polymer Network Materials via Thiourethane Dynamic Chemistry
NU2019-126 INVENTORS John Torkelson* Lingqiao Li Xi Chen SHORT DESCRIPTION A class of reprocessa
b
le, PU-like polymer networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences > Materials and Industrial Processes
Fusion Protein for Development of Transgenic Resistance to Lepidopteran Pests
A Specific, Eco-Friendly Approach to Pest Control Using Genetically Engineered
B
iopesticides A fusion protein comprised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/31/2025
|
Inventor(s):
B
ryony Bonning
Keywords(s):
Category(s):
Technology Classifications > Agricultural > Insect Control
,
Technology Classifications > Agricultural > Therapeutics
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