Search Results - jeffrey+kopp

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Construct for Tetracycline Inducible Podocyte Specific Gene Expression in Mice
The National Institutes of Health announces the generation of a construct by ligating 2.5kb human podocin promoter sequence to gene encoding reverse tetracycline-controlled transcriptional activator which enables tetracycline-inducible podocyte specific gene of interest expression with another construct consisting of tetracycline responsive element,...
Published: 4/8/2025   |   Inventor(s): Jeffrey Kopp
Keywords(s): CONSTRUCT, Expression, Gene, IDXXXX, INDUCIBLE, IXXXXX, Mice, Podocyte, Specific, Tetracycline
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
Conditionally Immortalized Human Podocyte Cell Lines
Podocytes, cells of the visceral epithelium in the kidneys, are a key component of the glomerular filtration barrier. Podocyte damage and loss contribute to the initiation of glomerular diseases. NIH investigators recently established long-term urinary cell cultures from two patients with focal segmental glomerulosclerosis and two healthy volunteers,...
Published: 4/8/2025   |   Inventor(s): Toru Sakairi, Jeffrey Kopp
Keywords(s): Cell, Conditionally, ESTABLISHED, Human, IDXXXX, immortalized, IXXXXX, Lines, Podocyte, RXXXXX, Urine
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
Model for Study of Glomerular Disorders: Conditionally-Immortalized Mouse Podocyte Cell Line with Tet-on-Regulated Gene Expression
Podocytes, cells of the visceral epithelium in the kidneys, are a key component of the glomerular filtration barrier. As such, they play a vital role in glomerular disorders, which are a major cause of chronic kidney disease. Examples of these disorders include focal segmental glomerulosclerosis, membranous glomerulonephritis, minimal change disease,...
Published: 10/28/2024   |   Inventor(s): Jeffrey Kopp
Keywords(s): ACXXXX, AXXXXX, Focal segmental glomerulosclerosis, Focal segmental glomerulosclerosis; Focal segmental glomerul, Glomerulonephritis, Idiopathic minimal change nephrotic syndrome, IDXXXX, IXXXXX, Minimal Change Disease, UAXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, Application > Research Materials
Monoclonal Antibodies to HIV-1 Vpr
Available for licensing are monoclonal antibodies against HIV-1 viral protein R (Vpr) and the respective hybridoma cell lines expressing the same. The antibodies provide a means for detecting HIV-1 Vpr. Currently, the mechanism of HIV pathogenesis believed to involve viral replication inside immune cells and other cells. At present, there are no...
Published: 4/8/2025   |   Inventor(s): Ulrich Schubert, Terrence Phillips, Jonathan (Jon) Yewdell, Jeffrey Kopp
Keywords(s): (4)r syndrome, Abdominal obesity metabolic syndrome, AC6XXX, ACCESSORY, ACXXXX, Antibody-based, AXXXXX, Biological, C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, DA4AXX, DA4XXX, DAXXXX, DB4AXX, DB4XXX, DBXXXX, DC5AXX, DC5XXX, DCXXXX, DDXXXX, Detection, DXXXXX, G syndrome, HIV-1, Hypertelorism with esophageal abnormality and hypospadias, Metabolic syndrome X, Methodologies, monoclonal, N syndrome, Protein, QUANTIFICATION, R(6) syndrome, R(7) syndrome, SAMPLES, Syndrome X, VPR, W syndrome, W syndrome; Syndrome W
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Diagnostics