Search Results - akt

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Methods of Producing Effective T-cell Populations Using Akt Inhibitors
Abstract: Adoptive cell therapy (ACT) uses cancer reactive T-cells to effectively treat patients. However, several obstacles inhibit the successful use of ACT for cancer treatment.  Current approaches for the expansion of T-cells may produce T-cells with a terminally differentiated phenotype that is associated with diminished anti-tumor activity and...
Published: 4/8/2024   |   Inventor(s): Joseph Crompton, Nicholas Restifo
Keywords(s): act, AKT, CANCER, Immunotherapy. Adoptive Cell Therapy, Protein kinase B, Restifo, T-CELLS
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials
Small-Molecule Inhibitors of Human Galactokinase for the Treatment of Galactosemia and Cancers
Lactose, found in dairy products and other foods, is comprised of two simple sugars, glucose and galactose. In galactosemia, where galactose is not properly metabolized, build-up of toxic compounds, such as galactose-1-phosphate, can lead to liver disease, renal failure, cataracts, brain damage, and even death if this disorder is left untreated. Currently,...
Published: 10/28/2024   |   Inventor(s): Matthew Boxer
Keywords(s): AKT, CANCER, CB7XXX, CBXXXX, CXXXXX, Galactokinase, Galactose, Galactosemia, IBXXXX, Inhibitors, IXXXXX, lactose, Metabolism, PTEN, rare disease, small molecule, UAXXXX
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials
Anticancer Agents for Triple-Negative Breast Cancers
Selectively Kills EGFR+, HER2+, and HER+3 Tumors via New Mechanism, Enabling These Tumors to Overcome Resistance to Current TherapyThis first-in-class compound selectively kills cancer cells without harming normal tissues. The Epidermal Growth Factor Receptor (EGFR) family members -- EGFR, Human Epidermal Growth Factor Receptor-2 (HER2) and Human Epidermal...
Published: 11/19/2021   |   Inventor(s): Brian Law, Ronald Castellano
Keywords(s): Akt, breast cancer, Compound, EGFR, Her2, HER2/neu receptor, Therapeutic
Category(s): Technology Classifications > Human Health Care > Therapeutics