Search Results - deletion+7

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New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological, Fibrotic or Cardiovascular Indications
SMAD7 conditional knockout mice are available for licensing. SMAD7 can be knocked out by breeding with CRE-recombinase transgenic mice with a variety of promoters to yield tissue or cell type-specific deletions of SMAD7. SMAD7 has been shown to play a role in bone morphogenesis, cardiovascular tissue generation, immune regulation and fibrosis. Therefore,...
Published: 10/28/2024   |   Inventor(s): Marilyn Diaz
Keywords(s): BAXXXX, Chromosome 7, monosomy, Conditional, Deletion, Deletion 7, Gene., Mouse, RXXXXX, Scleroderma, Scleroderma, systemic, SMAD7, Strain
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, ResearchProducts > Animal Models
Conditional V2 Vasopressin Receptor Mutant Mice as a Model to Study X-linked Nephrogenic Diabetes Insipidus (XNDI)
X-linked nephrogenic diabetes insipidus (XNDI) is a severe kidney disease caused by inactivating mutations in the V2 vasopressin receptor (V2R) gene that result in the loss of renal urine-concentrating ability. At present, no specific pharmacological therapy has been developed for XNDI, primarily due to the lack of suitable animal models. This technology...
Published: 10/28/2024   |   Inventor(s): Jurgen Wess
Keywords(s): ACXXXX, AXXXXX, Chromosome 7, monosomy, Conditional, Deletion 7, DIABETES, Insipidus, Mice, MUTANT, Nephrogenic, Nephrogenic diabetes insipidus, Novel, RECEPTOR, RXXXXX, STRATEGY, Studied, treatment, V2, VASOPRESSIN, X-LINKED
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials
Antigenic Chimeric Tick-Borne Encephalitis Virus/Dengue Virus Type 4 Recombinant Viruses
The tick-borne encephalitis virus (TBEV) complex is a group of viruses that can cause severe neutrotropic disease and up to thirty percent (30%) mortality. While these viruses can be found in many parts of the world, the largest impact of the disease occurs in Europe and Russia, where approximately fourteen thousand (14,000) hospitalized TBEV cases...
Published: 10/28/2024   |   Inventor(s): Brian Murphy, Amber Engel, Alexander Pletnev
Keywords(s): 4, ANTIGENIC, CANDIDATES, CAUSED, chimeric, Chromosome 7, monosomy, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion 7, Dengue (Flaviviridae), Development, Disease, DXXXXX, ENCEPHALITIS, Patent Category - Biotechnology, Prevention, recombinant, TBEV, TBEV/DEN4, TICK-BORNE, Tick-borne encephalitis, TYPE, Vaccine, virus, Virus/dengue, Viruses
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
Prostatic Adenocarcinoma Cells Expressing or Lacking the Tumor Suppressor Gene PTEN
PTEN is a tumor suppressor gene that is frequently deleted or mutated in a variety of human cancers, including prostate, breast, endometrial, lung, and ovarian cancers. In prostate cancer cells, PTEN deletion is the most common event observed. The loss of PTEN is thought to play and important role in tumor cell proliferation and metastasis due to...
Published: 4/8/2024   |   Inventor(s): Michael Quon, Derek Leroith
Keywords(s): ADENOCARCINOMA, BREAST CANCER, CA1XXX, CANCER, CAXXXX, CCXXXX, Cells, CHARACTERIZATION, Chromosome 7, monosomy, CXXXXX, Deletion 7, endometrial, Expressing, Gene, IGF1R, lung cancer, MEN 1, OVARIAN CANCER, PROSTATE CANCER, PTEN, tumor suppressor, Zollinger-Ellison syndrome
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
Respiratory Syncytial Virus (RSV) Vaccines Based on Promoter-Proximate Attenuation
Available for licensing and commercial development is a patent estate and related biological materials for producing therapeutic or prophylactic vaccines against Respiratory Syncytial Virus (RSV). The claimed vaccine strategy relates to the engineering and creation of live-attenuated RSV vaccine candidates by shifting the position of one or more viral...
Published: 10/28/2024   |   Inventor(s): Peter Collins, Brian Murphy, Ursula Buchholz, Stephen Whitehead, Christine Krempl
Keywords(s): ATTENUATE, Attenuated, ATTENUATING, ATTENUATION, Chromosome 7, monosomy, DC5BXX, DC5XXX, DCXXXX, Deletion 7, DXXXXX, GENES, Noonan syndrome, NS1, Promoter-proximal, RSV, RSV virus, RSV/PIV, Syncytial, Vaccine, Vaccine Design, VACCINE DEVELOPMENT, VACCINE VECTORS, vaccines, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines
Neutralization of Hepatitis C Virus (HCV)
Available for licensing and commercial development are compositions and methods for preventing and/or treating infection caused by hepatitis C virus (HCV). The invention is based on mapping studies conducted by the inventors of two epitopes within HCV E2: epitope I and epitope II. It has been discovered that epitope I is involved in virus neutralization...
Published: 10/28/2024   |   Inventor(s): Pei Zhang
Keywords(s): antibodies, ANTIBODY, BINDING, C, Chromosome 7, monosomy, CONTROL, DB4BXX, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, Deletion 7, DXXXXX, E2, HCV, HCV Vaccine, Hepatitis A, Hepatitis D, Hepatitis E, Hepititis, Heptitis, Infection, Interference-mediated, INTERFERING, Methods, Modulate, Neutralization, Patent Category - Chemistry, Protein, SITE, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Therapeutics
Monoclonal Antibodies Against Dengue and Other Viruses With Deletion in Fc Region
The four dengue virus (DENV) serotypes (DENV-1 to DENV-4) are the most important arthropod-borne flaviviruses in terms of morbidity and geographic distribution. Up to 100 million DENV infections occur every year, mostly in tropical and subtropical areas where vector mosquitoes are abundant. Infection with any of the DENV serotypes may be asymptomatic...
Published: 10/28/2024   |   Inventor(s): Robert Purcell, Ching-juh Lai, Ana Goncalvez
Keywords(s): (4)r syndrome, Against, antibodies, C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, Chromosome 7, monosomy, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DDXXXX, Deletion, Deletion 7, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, DXXXXX, FC, G syndrome, Hemorrhagic fever, Hypertelorism with esophageal abnormality and hypospadias, monoclonal, N syndrome, Q fever, R(6) syndrome, R(7) syndrome, Region, Syndrome X, UAXXXX, UBXXXX, Viruses, W syndrome, W syndrome; Syndrome W
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Vaccines, Application > Therapeutics
VAC-BAC Shuttle Vector System for Generating Recombinant Poxviruses
This invention relates to a VAC-BAC shuttle vector system for the creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome. A VAC-BAC is a bacterial artificial chromosome (BAC) containing a vaccinia virus genome (VAC) that can replicate in bacteria and produce infectious virus in mammalian cells.
Published: 10/28/2024   |   Inventor(s): Arban Domi, Bernard Moss
Keywords(s): Chromosome 7, monosomy, DB4BXX, DB4XXX, DBXXXX, DC1XXX, DCXXXX, Deletion 7, DXXXXX, SHUTTLE, System, VAC-BAC, Vector
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease
Dengue Tetravalent Vaccine Containing a Common 30 Nucleotide Deletion in the 3'-UTR of Dengue Types 1, 2, 3, and 4
The invention relates to a dengue virus tetravalent vaccine containing a common 30-nucleotide deletion (delta30) in the 3'-untranslated region (UTR) of the genome of dengue virus serotypes 1, 2, 3, and 4. The previously identified delta30 attenuating mutation, created in dengue virus type 4 (DEN4) by the removal of 30 nucleotides from the 3'-UTR, is...
Published: 10/28/2024   |   Inventor(s): Brian Murphy, Lewis Markoff, Barry Falgout, Kathryn Hanley, Joseph Blaney, Stephen Whitehead
Keywords(s): 3'-UTR, ANTIGENIC, chimeric, Chromosome 7, monosomy, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, Deletion, Deletion 7, DENGUE, Dengue (Flaviviridae), DXXXXX, Nucleotide, Tetravalent, UAXXXX, UBXXXX, Vaccine, Viruses
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines
PTH2 and PTH1 Receptor Ligands
Parathyroid hormone receptors found on osteoblasts in bone and renal tubule cells in kidney elevate blood calcium levels when stimulated by parathyroid hormone (PTH) and PTH-related protein (PTHrP). Excessive secretion of PTH from the parathyroid gland results in primary hyperparathyroidism. Production of PTHrP by various tumors results in humoral...
Published: 10/28/2024   |   Inventor(s): Ted Usdin, Samuel Hoare
Keywords(s): Chromosome 7, monosomy, Deletion 7, IAXXXX, IB1DXX, IBXXXX, IXXXXX, NB1DXX, NBXXXX, NXXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Neurology, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics