Search Results - tumor

25 Results Sort By:
Optical Reservoir Computing for Lung Tumor Movement Prediction in Radiation Therapy Applications
RPI ID: 2020-059-201 Innovation Summary: A recurrent neural network (RNN) architecture is developed to predict tumor movement during radiation therapy. The model uses time-series data from respiratory and anatomical signals to forecast tumor position in real time. It supports adaptive radiation delivery and minimizes exposure to surrounding healthy...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Alex Hollingsworth, Clare Thiem, Nathan McDonald, Zhizhuo Liang, Zhaoran Huang
Keywords(s): CT, machine-learning, motion prediction, radiation therapy, real-time, reservoir computing, tumor
Category(s): Biotechnology and the Life Sciences
Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 7/17/2025   |   Updated: 3/6/2024   |   Inventor(s): Cun Yu Wang, Jia Lingfei
Keywords(s): Cancer stem cells, Epigenetics, Immunooncology, Oncology Immunotherapy, Tumor
Category(s): Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Gene Therapy And Editing
Extremely Rapid Method to Isolate Neoantigen Reactive T Cell Receptors (TCRs)
Summary: NCI seeks commercial partners to co-develop and/or license a novel method to identify neoantigen reactive T cells and TCRs. Description of Technology: Adoptive cell transfer (ACT) uses tumor infiltrating lymphocytes (TILs) that recognize unique antigens expressed by cancer cells (“neoantigens”). Neoantigen specific TIL administration...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Sri Krishna, Paul Robbins, Rami Yoseph, James Yang, Kenichi Hanada, Frank Lowery, Steven Rosenberg
Keywords(s): act, Adoptive Cell Transfer, Immunotherapy, Neoantigen, Rosenberg, T Cell Receptor, TCR, TIL, tumor, Tumor Infiltrating Lymphocyte
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Gene-based Diagnostic Predicts Patient Response to Cancer Immunotherapy
Abstract: Immunotherapy is a promising method of treating cancer that leverages the immune system to promote tumor rejection. However, certain somatic mutations in cancer cells confer resistance to T cell-mediated cytolysis. To improve the effectiveness of immunotherapies for cancer, there exists a need to prospectively identify patients who are most...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Shashankkumar Patel, Nicholas Restifo
Keywords(s): CRISPR, diagnostic, Gene, Immunotherapy, T-cell, tumor
Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Calcium (Ca2+) Flux-Dependent Method to Detect and Isolate Tumor Reactive T Cell Receptors (TCRs)
Abstract: T cells with T cell receptors (TCRs) for cancer-specific antigens are used for adoptive cell therapy (ACT), wherein a patient’s T cells are redirected against their own cancer. However, these isolated T cells may require further ex vivo manipulation to enhance their anti-tumor activity. The ex vivo manipulation of these T cells, or the selection...
Published: 8/5/2025   |   Updated: 8/2/2023   |   Inventor(s): Douglas Palmer, Anna Pasetto, Nicholas Restifo, Steven Rosenberg
Keywords(s): act, Adoptive Cell Transfer, CA2+, Calcium Ion, Immunotherapy, Rosenberg, T Cell Receptor, TCR, tumor
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
A Rapid Method of Isolating Neoantigen-specific T Cell Receptor Sequences
Abstract: Tumors can develop unique genetic mutations which are specific to an individual patient. Some of these mutations are immunogenic; giving rise to autologous T cells which are tumor-reactive. Once isolated and sequenced, these neoantigen-specific TCRs can form the basis of effective adoptive cell therapy cancer treatment regimens; however, current...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Yong-Chen Lu, Zhili Zheng, Peter Fitzgerald, Steven Rosenberg
Keywords(s): CANCER, Immunotherapy, Single Cell, T-cell Receptors, TCR, tumor
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology
Novel Method to Group Pixels for Medical Imaging (UCLA Case No. 2022-290)
Summary: UCLA researchers in the Department of Radiological Sciences have developed a new computational pipeline for identifying lesions in MRI data. Background: Prostate cancer is one of the most common cancer types with 12.6% of men diagnosed within their lifetime. Prostate cancer ranks as the 2nd leading cause of cancer-related deaths in the...
Published: 2/14/2025   |   Updated: 4/4/2023   |   Inventor(s): Ashley Yeager
Keywords(s): AI algorithms, Algorithm, algorithmic cancer detection, Cancer, cancer detection, DICOM, multiparametric MRI (mpMRI), prostate cancer, Radiology, Software & Algorithms, Tumor, Tumor Marker
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Digital Health
2023-009: Repurposing Native Cytokine Receptor Signaling for Adoptive T Cell Therapy of Cancer
SUMMARY: UCLA researchers in the Department of Radiation Oncology at the School of Medicine have identified a cytokine receptor endowing adoptively transferred T cells with new functions that enhance the potency of adoptively transferred T cells for the treatment of solid tumors, namely by restoring their functionality in the absence of conditioning...
Published: 10/8/2025   |   Updated: 1/13/2023   |   Inventor(s): Anusha Kalbasi
Keywords(s): Cancer, Immunotherapy, Tumor
Category(s): Life Science Research Tools, Therapeutics
Tumor Associated Calcium Signal Transducer 2 (TACSTD2)-Overexpressing Huh7.5 Cells That Are More Permissive to HCV Cell Entry and Replication Compared to the Model Huh7.5 Cell Line
Worldwide, 130-150 million individuals are chronically infected with hepatitis C virus (HCV), a major cause of liver-associated morbidity and mortality worldwide. Despite recent advances in antiviral drugs that can cure some individuals, a rapid decline of the global disease burden is hampered by remarkably high treatment costs and a high number of...
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): Vandana Sekhar, Patrizia Farci
Keywords(s): 2, Associated, CALCIUM, Cells, Huh7.5, Signal, TACSTD2-overexpressing, TRANSDUCER, tumor
Category(s): Collaboration Sought > Licensing
RL-5 – Rabbit T Cell Line Derived From a Herpesvirus Ateles-induced Rabbit Tumor From the Inbred Rabbit Line B/J
Details for this material are provided in the NIH AIDS Reagent Program Catalog (Catalog# 341): https://www.aidsreagent.org/reagentdetail.cfm?t=cell_lines&id=152.
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): Bishop Hague
Keywords(s): Ateles-induced, B/J., Cell, DERIVED, HERPESVIRUS, Inbred, Line, Listed LPM Ano as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, rabbit, RL-5-, RM, T, tumor, VLXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Infectious Disease, Application > Research Materials
1 2 3