Search Results - tumor

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Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 3/6/2024   |   Inventor(s): Cun-Yu Wang, Jia Lingfei
Keywords(s): Cancer stem cells, Epigenetics, Immunooncology, Oncology Immunotherapy, Tumor
Category(s): Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Gene Therapy And Editing
Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)
UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...
Published: 2/15/2024   |   Inventor(s): Antoni Ribas
Keywords(s): Colon carcinoma, Immune checkpoint blockade, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), PD-1, PD-L1, Resistant tumors, Signaling pathways, Small molecule therapeutics, Tumor
Category(s): Life Science Research Tools, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)
Extremely Rapid Method to Isolate Neoantigen Reactive T Cell Receptors (TCRs)
Abstract: Adoptive cell transfer (ACT) uses tumor infiltrating lymphocytes (TILs) that recognize unique antigens expressed by cancer cells (“neoantigens”). Neoantigen specific TIL administration in patients has resulted in long term regression of certain metastatic cancers. However, one of the challenges of ACT and engineered T cell receptor (TCR) therapies...
Published: 4/8/2024   |   Inventor(s): Sri Krishna, Paul Robbins, Rami Yoseph, James Yang, Kenichi Hanada, Frank Lowery, Steven Rosenberg
Keywords(s): act, Adoptive Cell Transfer, Immunotherapy, Neoantigen, Rosenberg, T Cell Receptor, TCR, TIL, tumor, Tumor Infiltrating Lymphocyte
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Gene-based Diagnostic Predicts Patient Response to Cancer Immunotherapy
Abstract: Immunotherapy is a promising method of treating cancer that leverages the immune system to promote tumor rejection. However, certain somatic mutations in cancer cells confer resistance to T cell-mediated cytolysis. To improve the effectiveness of immunotherapies for cancer, there exists a need to prospectively identify patients who are most...
Published: 9/13/2024   |   Inventor(s): Shashankkumar Patel, Nicholas Restifo
Keywords(s): CRISPR, diagnostic, Gene, Immunotherapy, T-cell, tumor
Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Calcium (Ca2+) Flux-Dependent Method to Detect and Isolate Tumor Reactive T Cell Receptors (TCRs)
Abstract: T cells with T cell receptors (TCRs) for cancer-specific antigens are used for adoptive cell therapy (ACT), wherein a patient’s T cells are redirected against their own cancer. However, these isolated T cells may require further ex vivo manipulation to enhance their anti-tumor activity. The ex vivo manipulation of these T cells, or the selection...
Published: 4/8/2024   |   Inventor(s): Douglas Palmer, Anna Pasetto, Nicholas Restifo, Steven Rosenberg
Keywords(s): act, Adoptive Cell Transfer, CA2+, Calcium Ion, Immunotherapy, Rosenberg, T Cell Receptor, TCR, tumor
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
A Rapid Method of Isolating Neoantigen-specific T Cell Receptor Sequences
Abstract: Tumors can develop unique genetic mutations which are specific to an individual patient. Some of these mutations are immunogenic; giving rise to autologous T cells which are tumor-reactive. Once isolated and sequenced, these neoantigen-specific TCRs can form the basis of effective adoptive cell therapy cancer treatment regimens; however, current...
Published: 4/8/2024   |   Inventor(s): Yong-Chen Lu, Zhili Zheng, Peter Fitzgerald, Steven Rosenberg
Keywords(s): CANCER, Immunotherapy, Single Cell, T-cell Receptors, TCR, tumor
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology
Novel Method to Group Pixels for Medical Imaging (UCLA Case No. 2022-290)
Summary: UCLA researchers in the Department of Radiological Sciences have developed a new computational pipeline for identifying lesions in MRI data. Background: Prostate cancer is one of the most common cancer types with 12.6% of men diagnosed within their lifetime. Prostate cancer ranks as the 2nd leading cause of cancer-related deaths in the...
Published: 7/31/2023   |   Inventor(s): Ashley Yeager
Keywords(s): AI algorithms, Algorithm, algorithmic cancer detection, Cancer, cancer detection, DICOM, multiparametric MRI (mpMRI), prostate cancer, Radiology, Software & Algorithms, Tumor, Tumor Marker
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Digital Health
2023-009: Repurposing Native Cytokine Receptor Signaling for Adoptive T Cell Therapy of Cancer
SUMMARY: UCLA researchers in the Department of Radiation Oncology at the School of Medicine have identified a cytokine receptor endowing adoptively transferred T cells with new functions that enhance the potency of adoptively transferred T cells for the treatment of solid tumors, namely by restoring their functionality in the absence of conditioning...
Published: 7/19/2023   |   Inventor(s): Anusha Kalbasi
Keywords(s): Cancer, Immunotherapy, Tumor
Category(s): Life Science Research Tools, Therapeutics
Tumor Associated Calcium Signal Transducer 2 (TACSTD2)-Overexpressing Huh7.5 Cells That Are More Permissive to HCV Cell Entry and Replication Compared to the Model Huh7.5 Cell Line
Worldwide, 130-150 million individuals are chronically infected with hepatitis C virus (HCV), a major cause of liver-associated morbidity and mortality worldwide. Despite recent advances in antiviral drugs that can cure some individuals, a rapid decline of the global disease burden is hampered by remarkably high treatment costs and a high number of...
Published: 7/25/2024   |   Inventor(s): Vandana Sekhar, Patrizia Farci
Keywords(s): 2, Associated, CALCIUM, Cells, Huh7.5, Signal, TACSTD2-overexpressing, TRANSDUCER, tumor
Category(s): Collaboration Sought > Licensing
RL-5 – Rabbit T Cell Line Derived From a Herpesvirus Ateles-induced Rabbit Tumor From the Inbred Rabbit Line B/J
Details for this material are provided in the NIH AIDS Reagent Program Catalog (Catalog# 341): https://www.aidsreagent.org/reagentdetail.cfm?t=cell_lines&id=152.
Published: 7/25/2024   |   Inventor(s): Bishop Hague
Keywords(s): Ateles-induced, B/J., Cell, DERIVED, HERPESVIRUS, Inbred, Line, Listed LPM Ano as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, rabbit, RL-5-, RM, T, tumor, VLXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Infectious Disease, Application > Research Materials
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