Search Results - target

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A Novel Virus-Based Expression System
The present invention is related to a recombinant viral vector for vaccines. Currently available poxvirus vectors for humans and other animals exhibit suboptimal expression of recombinant gene(s) and high expression of vector proteins which causes weak immunogenicity and high anti-vector immune response. The present novel virus-based expression vectors...
Published: 10/28/2024   |   Inventor(s): Linda Wyatt, Bernard Moss
Keywords(s): Expression, Gene, GENES, High, LOW, Non-Replicating, System, TARGET, vaccinia, Vector, virus, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WNXXXX, XEXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics
Human and Veterinary Cancer Therapeutic Agent Utilizing Anthrax Toxin-Based Technology
Due to the disorganized nature of blood vessels that run through tumors, chemotherapeutic agents often fail to penetrate tumors and kill cancer cells at the tumor’s center. This can lead to ineffective chemotherapeutic treatments, because tumors can quickly grow back if the entire tumor is not destroyed. NIH researchers have developed a therapeutic...
Published: 10/28/2024   |   Inventor(s): Stephen Leppla, Shihui Liu, Thomas Bugge, Diane Peters, Jie Liu, Alexander Wein, Kuang-Hua Chen, Christopher Bachran, Damilola Phillips, Henning Hansen, Sarah Arnett, Clinton Leysath
Keywords(s): Against, AMOUNTS, Anthrax, AnthraxToxins, ANTIGEN, B, CA1BXX, CB1AXX, CB1BXX, CB1XXX, CB3CXX, CBXXXX, Cells, Cell-Surface, CMG2, COMPLEMENTARY, CONTAIN, Containing, CXXXXX, Cytolethal, Distending, EFFICACY, Efficient, ENGINEERED, exclusively, Exploiting, FELINE, FELINE Leukemia, FORM, Fusion, fusion proteins, Having, High, IC2-PA, Identifying, Improved, Leppla, Listed LPM McCue as of 4/15/2015, MARKER, Metallo..., MULTIMERIC, Mutated, Nature, Octamers, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protective, Protein, proteins, SOLID, SPECIFICALLY, Specificity, Strong, TARGET, Targeting, That, THERAPY, toxin, TOXINS, tumor, Types, UAXXXX, VARIANTS, VASCULATURE, VETERINARY
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases
Antimalarial Inhibitors that Target the Plasmodial Surface Anion Channel (PSAC) Protein and Development of the PSAC Protein as Vaccine Targets
There are two related technologies, the first being small molecule inhibitors of the malarial plasmodial surface anion channel (PSAC) and the second being the PSAC protein itself as a vaccine candidate. The PSAC protein is produced by the malaria parasite within host erythrocytes and is crucial for mediating nutrient uptake. In vitro data show that...
Published: 10/28/2024   |   Inventor(s): Sanjay Desai
Keywords(s): Anion, ANTIMALARIAL, CHANNEL, DC2XXX, DCXXXX, DXXXXX, Plasmodial, Surface, TARGET, THERAPY
Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease
Methods and Devices for Transcatheter Cerclage Annuloplasty
The invention relates to techniques and devices for cardiovascular valve repair, particularly annuloplasty techniques and devices in which tensioning elements are positioned to treat regurgitation of the mitral valve or tricuspid valve. More specifically, the technology pertains to a new device for myocardial septal traversal ("cerclage reentry") that...
Published: 10/28/2024   |   Inventor(s): Robert Lederman
Keywords(s): AB3FXX, ABXXXX, Annuloplasty, AXXXXX, CAPTURE, Cerclage, DEVICE, Expandable, Mesh, Patent Category - Mech/Elect/Soft, TARGET, Transcatheter
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Modulation of Leucine-rich Repeats and Calponin Homology Domain-containing Protein 4 (Lrch4) Activity for Therapeutic Applications
NIH Inventors have recently discovered a novel Leucine-rich repeat and calponin homology domain-containing protein 4 (Lrch4) in a proteomic screen of the plasma membrane of lipopolysaccharide (LPS)-exposed macrophages. Expression data by RT-PCR revealed that all Lrch family members (1-4) are expressed in macrophages, but only Lrch4 was recruited into...
Published: 10/28/2024   |   Inventor(s): Michael Fessler
Keywords(s): CB6XXX, CBXXXX, CXXXXX, DISEASES, GB1XXX, GBXXXX, GXXXXX, IB3XXX, IBXXXX, INFLAMMATORY, IXXXXX, Lrch4, Sepsis, TARGET, therapeutic
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology
Strategy to Isolate Regulatory T Cells Capable of Inducing Robust Immunoregulation
Utilizes Cell-Surface Markers to Isolate and Manipulate Treg Cells during Treatment and Prevention of Autoimmune and Inflammation-Mediated DiseasesThis strategy enables the isolation of a potent population of regulatory T cells for autoimmune disease treatment by identifying specific surface markers characteristic of this cell population. The National...
Published: 12/7/2021   |   Inventor(s): Christopher Fuhrman, Todd Brusko
Keywords(s): Autoimmune disease, CD226, makers, Regulatory T Cells, Target, TIGIT
Category(s): Technology Classifications > Human Health Care > Therapeutics
Potent Compounds for the Treatment of Canavan Disease & Cancers
Project ID: D2016-55Invention Description:Elevated levels of N-acetylaspartate (NAA) is a major hallmark of Canavan disease (CD), which currently has no cure or standard course of treatment. Mutations in the aspA gene, which encodes aspartoacylase, render it unable to adequately catalyze the synthesis of NAA in CD patients. The Nat8l gene encodes aspartate...
Published: 10/29/2024   |   Inventor(s): Ronald Viola, Bharani Thangavelu, Qinzhe Wang, Vinay Mutthamsetty
Keywords(s): Canavan, Cancer, Enzyme, Inhibitor, Neurological, Target
Category(s): Rare Disease
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury....
Published: 11/20/2024   |   Inventor(s): Frank Anania, Pradeep Kumar
Keywords(s): Enzyme/Protein, Hepatology, Immunology/Inflammation, Target
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
Targeting Peptide Improves Accurate Myocarditis Imaging and Diagnosis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 7/30/2024   |   Inventor(s): Michael E. Davis, Mario Martinez
Keywords(s): Biomarker, Cardiovascular, Enzyme/Protein, Imaging, Target
Category(s): TechPub Algolia > Diagnostics
Use of Small Molecule Inhibitors as Anti-Thrombotic Agents
ont-size:12px">Project ID: D2016-03 Background Various ailments, including systemic lupus erythematosus (SLE), rheumatoid arthritis and certain cancers can cause a person to suffer a thrombotic event. There are various therapies currently used for treating pro-thrombotic platelets, including molecules that can be divided into families based on mechanism...
Published: 5/9/2024   |   Inventor(s): Randall Worth, Glenn Westphal, Brenton Keeley, Leah Wuescher
Keywords(s): Anti-thrombotic, Inhibitor, Platelet, Target, Thrombosis
Category(s): Cardiovascular, Renal, & Metabolism
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