Search Results - flavivirus

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Repurposed Use of the Alkaloids Emetine and Cephaeline to Treat Zika Virus Infection
This technology includes the use of two related compounds, Emetine and Cephaeline, as a potent inhibitor of the Zika virus (ZIKV). Emetine and it's analog Cephaeline were identified in a high-throughput assay aimed at identifying anti-ZIKV compounds. Both Emetine and Cephaeline are potent inhibitors of ZIKV infection in cell culture, and Emeline is...
Published: 7/25/2024   |   Inventor(s): Emily Lee, Wei Zheng, Miao Xu, Ruili Huang, Shu Yang, Wenwei Huang, Khalida Shamim, Hao Li, Hengli Tang
Keywords(s): compounds, Emetine, Flavivirus, Infection, Prevention, treatment, VLXXXX, WIXXXX, WKXXXX
Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials
Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccines
CDC researchers have developed a potent immunogenic enhancer polypeptide useful for improving flavivirus vaccines. Flaviviruses such as dengue virus (1, 2, 3 and 4), Japanese encephalitis virus, Murray Valley encephalitis virus, St. Louis encephalitis virus, yellow fever virus and tick-borne encephalitis virus are a great burden on public health. ...
Published: 7/25/2024   |   Inventor(s): Holly Hughes, Gwong-Jen Chang
Keywords(s): ADJUSTMENT, adjuvant, Adjuvant-like, BCXXXX, Boost, BOOSTING, CD4, CDC Docket Import, CDC Docket Import CDC Prosecuting, Cell, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DENGUE, DENGUE FEVER, Dengue Vaccine, Dengue-1, Dengue-2, Dengue-Like, DXXXXX, Epitope, Flavivirus, FLAVIVIRUSES, Identification, in vivo, JAPANESE ENCEPHALITIS VIRUS, Listed LPM Houze as of 4/15/2015, Mosquito, Mosquitoes, Nile, OID-NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRIMER, T, THEREOF, Tick-Bone, TICK-BORNE, UBXXXX, Vaccine, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, Vector-borne, Vector-borne diseases, virus, VLXXXX, VOXXXX, WAXXXX, West, WIXXXX, WJXXXX, WMXXXX, XCXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines, Application > Therapeutics, Application > Research Materials, Application > Consumer Products, TherapeuticArea > Infectious Disease
Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccines
CDC researchers have identified and characterized discrete flavivirus cross-reactive epitopes useful for improving serodiagnosis and vaccination of flaviviruses, such as dengue virus, yellow fever virus, Japanese encephalitis virus, West Nile virus and the tick-borne encephalitis viruses. The flavivirus envelope glycoprotein is one of the primary antigens...
Published: 7/25/2024   |   Inventor(s): Wayne Crill, Gwong-Jen Chang
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CHARACTERIZATION, Cross-Reactive, Envelope, Epitopes, Flavivirus, GLYCOPROTEIN, LOCALIZATION, Methods, OID-NCEZID-DVBD, Their, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Occupational Safety and Health, ResearchProducts > Antibodies, Application > Research Materials, Application > Therapeutics, Application > Diagnostics
Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnostics
CDC scientists have developed recombinant flavivirus nucleic acids for the generation of broad protective immunity against flaviviruses, as well as the development of sensitive serologic diagnostic tools. Mosquito borne viral encephalitis is often caused by a flavivirus, such as Japanese encephalitis virus, dengue virus or West Nile virus. Infection...
Published: 7/25/2024   |   Inventor(s): Gwong-Jen Chang
Keywords(s): Acid, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Flavivirus, Infection, Nucleic, OID-NCEZID-DVBD, Prevention, vaccines, VLXXXX, VOXXXX, WBXXXX, WDXXXX, WIXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, Application > Research Materials, Application > Consumer Products, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment
Full-Length Infectious cDNA Clones of Tick Borne Flavivirus
The tick-borne encephalitis virus complex of flavivirus family includes tick-borne encephalitis (TBEV), Kyasanur forest disease, Langat, Louping ill, Negishi, Omsk hemorrhagic fever and Povassan viruses. These viruses are endemic throughout most of the Northern Hemisphere and except for Langat, cause human disease of varying severity that can have...
Published: 7/25/2024   |   Inventor(s): Robert Chanock (Estate), Alexander Pletnev
Keywords(s): Borne, cDNA, CLONES, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Flavivirus, FULL-LENGTH, Hemorrhagic fever, INFECTIOUS, Omsk hemorrhagic fever, Patent Category - Biotechnology, Q fever, SACGHS DNA Patent Initial Set, TICK, Tick-borne encephalitis, UAXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases
COMPOSITIONS AND METHODS FOR TREATING RNA VIRUS INFECTION
COMPOSITIONS AND METHODS FOR TREATING RNA VIRUS INFECTION Researchers at Stanford have developed a method of treating or preventing an infection from an RNA virus. Viral pathogens are an ongoing threat to public health worldwide. Upon infection, RNA viruses must remodel host machinery to promote viral protein production while also suppressing host...
Published: 3/17/2023   |   Inventor(s): Raul Andino-Pavlovsky, Judith Frydman
Keywords(s): Biomolecules, Dengue, Dengue Virus, Flavivirus, Proteostasis, Ribosomes
Category(s): Technology Classifications > Biology
BROADLY NEUTRALIZING ANTIBODIES AGAINST DENGUE VIRUS
BROADLY NEUTRALIZING ANTIBODIES AGAINST DENGUE VIRUS Researchers at Stanford and the Chan Zuckerberg Biohub have discovered cross reactive, broadly neutralizing human antibodies against all serotypes of dengue virus. Dengue virus (DENV) is transmitted to humans through mosquitos and causes approximately 400 million global infections each year. DENV...
Published: 3/17/2023   |   Inventor(s): Fabio Zanini, Derek Croote, Makeda Robinson, Leslie Goo, Stephen Quake, Shirit Einav, Krista McCutcheon
Keywords(s): Broadly Neutralizing Antibodies (bNAbs), Dengue, Flavivirus, Monoclonal Antibodies (mAbs), Single-cell Transcriptomics, Vaccine
Category(s): Technology Classifications > Biology